THE KOCH CATALYTIC AGENTS, BY DR. JULIAN F. BALDOR, M.D. - 1952

OUTLINE

I. Clinical Interpretation of Standard methods in Pulmonary Tuberculosis:

1. Pneumo:

   a. Plural adhesion

   b. Plural effusion

   c. Bilateralization

   d. Fibrosis

2. Thoracoplasty:

   a. Bronchiectasis

   b. Volumetric reduction

   c. Mediastinal displacement

   d. Bilateralization

   e. Tension cavity

3. Chemotherapy:

   a. Gold preparations

   b. Sulfone preparations

   c. Streptomycin

II. Clinical Interpretation of Standard Treatments in Virus Tuberculosis:

1. Leukemia:

   a. Transfusions:

   b. Deep therapy Surgery

   c. Chemotherapy

      1c. Radiate Phosp.

      2c. Aminotherin

      3c. Mustard gas

2. Hodgkin’s Disease:

   a. Transfusions

   b. Deep therapy

   c. Surgery

   d. Chemotherapy

3. Chronic Stage Leukemia:

   a. Case Examples:

      3a. Successful

         I. Teddy Singletary

         II. Mrs. J. W. Love

      3b. Unsuccessful

         I. Joe Walley Kay

         II. Miss M. Arthur

III. Summary and Conclusions

FORWARD

Mr. Chairman, Distinguished Guests;

I wish to express before this assembly a word of dedication to our courageous scientists, Dr. Albert L. Wahl, who sacrificed his life in behalf of humanitarian principles. He was significant as the living cornerstone in our present and future fight against the dark forces of our time. To his memory and his beloved wife, Mrs. Wahl. I respectfully dedicate this small contribution.

The history of tuberculosis infection and its conquest throughout the past years is very interesting indeed. It is very unfortunate, however, that my time is so limited that I will not have the opportunity to elaborate as fully as I would like.

Today we are facing very important facts, which deal particularly with the RESULTS OF RECOVERY in pulmonary tuberculosis infection and in virus tuberculosis infection, through the use of a Catalytic Agent discovered by the outstanding American scientist, Dr. William F. Koch, of Detroit, Michigan.

I want to say, that in the past five years in tuberculosis practice with the Koch Catalytic Agent. I have learned to face more important realities than I had ever expected to encounter. “THE BIRTH OF A SCIENCE,” a 320-page book, which has a large section dedicated to tuberculosis infection, has brought about my realization of how and what has been done for the tuberculosis sufferers. It has more significance to this disease than has an entire library of other celebrated books on the same subject. “THE BIRTH OF A SCIENCE” can be acknowledged as an excellent example of accomplishment and a living lesson useful to the classical system of Sanitarium, so expensive to our taxpayers and national economy.

We must remember the immortal words of Shakespeare: “What custom wills, we must in all things do it, for multitudinous errors would be heaped so high that truth could ne’er o’er pass it.”

Classifications:

This lecture will be a practical one:

The first part will be confined to the analysis of standard methods used by tuberculosis experts in the treatment of pulmonary tuberculosis infection, as well as the results obtained from such methods, and what the general practitioner can expect.

The second part will be confined to the question of virus tuberculosis infection, as an underlying factor in two well-known diseases: the Leukemia process and Hodgkin’s disease or Lymphogranulomatosis, along with clinical interpretations of standard treatments.

The third part gives to us the therapeutical results obtained with the Catalytic Agent in the treatment of pulmonary tuberculosis infection and Hodgkin’s disease.

I. Clinical Interpretation of Standard Methods in Pulmonary Tuberculosis

Patients with pulmonary tuberculosis are truly “infected ones.” For generations, this disease has been considered a contagious type and subject to isolation.

The great majority of tuberculosis specialists direct their remedial measures to the treatment “of the results of the disease,” rather than to the “cause of the disease,” particularly, the tubercular bacilli. Among the results of the disease the following are well known:

a. Cavity Formation
b. Pleurisy
c. Tubercular Bronchial Ulcerations
d. Tubercular Bronchial Stenosis, etc.

Let us go on and make an examination of how these patients react under the “standard” methods, and the complications arising from them.

1.) Pneumothorax (medical collapse)

Professor Amberson of Columbia University (New York) mentioned years ago that of forty qualified patients to collapsotherapy, only 25% showed complete recovery. The remaining 75% have taken the following patterns:

a. Unsatisfactory collapse by Pleural adhesions not susceptible to Pneumonolysis.
b. Pleural effusion of the great pleural cavity, often with secondary infection (emphysema).
c. Spread of the disease to the opposite lung or Bi-lateralization.
d. Fibrosis of parietal or visceral pleura.

2.) Thoracoplasty (surgical collapse)

O’Brien of Boston and Alexander Miller of Bellevue Hospital in New York adopted, years ago, the third and fourth stage operations in thoracoplastic technique, with not more than three ribs to be resected at any stage.

Even with this technical skill, however, complications still develop as follows:

a. Bronchiectasis of the lower lobe with secondary hemorrhage.
b. Volumetric reduction on the affected lung.
c. Mechanical displacements on chest cage structure.
d. Bi-lateralization of disease to the opposite lung from “tension cavity” by a process of back firing. Effect described recently by Dr. Norman J. Wilson on direct bronchoscopic examination.
e. Tension cavity followed by tubercular tracheobronchitis on which most of our knowledge has been acquired by two American investigators: Dr. Richard Overholt and Dr. Gertrude Zilverman.

3.) Chemotherapy

In this section, the standard methods used the most aggressive medications with unfavorable results to the human body and the oxidation mechanism and were highly destructive to the normal physiological process of life. Among them I recall:

a. Gold Preparations

Medication with heavy metals has been extensively used today in arthritis patients. This administration is frequently followed by dermatitis, ocular damage, acute nephritis, and so on…

b. Sulfone preparations (Mayo’s investigators)

In here we found three types of preparations: Promin, Promizole, and Diasone. Any of these are highly destructive to the normal protective mechanism of the reticulo-endothelial system. Following their administration, frequently there occurs severe hematological damage. This is true in the human body as well as in the animal experimentation, according to George H. Higgin’s research, which was published in the Journal of Clinical Pathology (1941).

c. Streptomycin

The active derivative of streptomycin is thought to be the Di-aldehyde-sugar streptose, which by losing one molecule of water, a system of carbonyl ethylene is obtained.

This substance has been the focus of the medical attention in tuberculosis practice for the past ten months. Drs. Feldman, Hinshaw and Mann of the Mayo Foundation and Mayo Clinic started the first experiments with this antibiotic in October 1945.

A year later, Dr. Feldman in collaboration with Dr. Karl Pfuetzer made public a summary of applications in human tuberculosis. In a series of 100 clinical cases, he admitted that streptomycin had beneficial results in “minimal tuberculosis infections,” but in the extensive destructive lesion of cavitation type, streptomycin does not respond well. This also applied to the fibrotic type of tuberculosis.

In my estimation, the lack of activity in a far advanced tuberculosis lesion of the fibrotic ulcerative type is due to local circulatory deficiency. From the pathological standpoint, these far advanced lesions are the ultimate state of obstructive endoarteritis, which circulatory deficiency makes it impossible for the antibiotic to reach the lesion.

The Streptomycin therapy is also facing two more important obstacles: (a.) Its rapid elimination after injection, and (b.) Its inactivation by the increased resistance of the host.

The Streptomycin “fast resistance” not only has the tendency to make this medication hopeless against the infective organism, but also has a tendency to increase the virulence of associated bacteria.

Very recently, Drs. Smith and Feldman made an additional sulfone preparation to the Streptomycin solutions, to overcome this situation of “drug resistance,” but without much success.

I would like to stress a very important fact concerning Streptomycin therapy in pulmonary tuberculosis infection, which is very similar to the effect of the Catalytic Agent in tuberculosis practice. Both medications (Glyoxylide or Streptomycin) produce, when they are injected, a rapid subsiding of the functional symptoms while improvement has not yet been observed in the radiological findings (chest X-Ray). In other words, the functional manifestations subside first, without correlation of the radiological symptoms.

For us who are practicing with the Catalytic Agent, this recovery mechanism is logical, if we remember that the last manifestation to come is the first to go, and the first manifestation to come, is the last to go. This statement-a stroke of genius-was made by Dr. Koch twenty years ago before we dreamed of the advent of Streptomycin therapy in the medical field.

Radiological manifestations in tuberculosis infection are the after effects of the disease, or more properly, the results of the tubercular bacillus infection, whose destructive power has been established over the lung tissue at the beginning of the infective process.

II. Clinical Interpretations of Standard Treatments in Virus Tuberculosis

To any medical student, the history of the tubercular bacilli and its discovery by a German scientist, Robert Koch, is a normal and well understand biological and bacteriological process.

On his birthday, young Koch received a microscope from his wife, Emma Frantz. It was from this time on that Koch began his first steps toward the discovery of the tubercular bacillus, until the moment he presented his paper before the Berlin Physiological Academy; this bacillus had been the bacteriological germ over which the great majority of scientists had spent many tedious and fruitless hours. They had tried to establish new ideas concerning the bacteriological properties of the bacillus and attempted to obtain a vaccine or serum with sufficient power to obtain a cure from the tuberculous infection in the human race.

It is along this path that Dr. Oswaldo Cruz, a distinguished investigator in the Brazilian School of Medicine, made an announcement in 1908. He said that Dr. Fontes, a member of the Institute, had proved the existence of a tubercular virus, which was believed capable of reproducing active tuberculous infection, when a preparation of tubercular bacillus culture was strained through Chamberlain filters.

This historical trend in bacteriological problems with the tubercular bacillus, occupies a definite position in the field of multiple clinical manifestations. I recall two important clinical diseases in which this virus has a direct influence in the development of clinical manifestations, namely, the Leukemia process and Hodgkin’s disease.

Franke and Much call to our attention certain typical granulations of a pseudo-tubercular type found inpatients afflicted with lymphatic leukemia. These granulations are known today as Much Granules and they are considered, also, as a transition in the bacteriology of the tubercular bacillus germ. However, whether or not they are related to the “enzymes group’ is an unanswered question in our day.

Any Hematological textbook considers Leukemia, as well as Hodgkin’s disease, a pathological process in which the tubercular virus is the primary etiological factor. As we did in pulmonary tubercular infection, let us make a brief analysis of the “standard treatments” used in daily practice in leukemia and Hodgkin’s disease.

Clinical manifestations in leukemia are well known to any practical physician. When the patient is in the acute stage, high fever is present. This temperature is not steady as a rule. When it is present, the peak of the temperature occurs in the evening, with chills and fever and sometimes with intestinal complaints. These first symptoms are frequently mistaken for polio infection or rheumatic fever.

Chest manipulations are present in the majority of these cases, with clinical manifestations of coughing with or without severe wheezing which occasionally lasts a few hours. Severe intercostal neuralgia is also present in small children.

The onset of the above manifestations is frequently established following acute exanthema, particularly the measles, in which the child’s resistance has been broken down. The temperature and chills are frequently associated with severe pains along the lower extremities, particularly in the fibula. This situation makes slow progress for weeks and on some occasions the patient is free of disturbances for many years. The blood count is not affected at this time unless perhaps slightly increased in the leucocytes as a manifestation of the virus entrance.

The majority of physicians fail to establish an early diagnosis in this incubation period. In my interpretation, there is one examination of importance that I would like to stress here-the chest X-Ray. The chest X-Ray made in this incubation period always reveals increasing lymph nodes along the pulmonary hilus, and on occasions, transitory atelectasis fields can be seen on these patients from day to day. This atelectasis or transitory stage is the result of enlarged lymph nodes, which put pressure over the medium or large bronchial lumena, and results in clinical manifestations of wheezing.

We have to be conscious of Leukemia in the same manner that we are conscious of appendicitis in an acute abdomen. In my estimation, the chest picture is a certain diagnostic weapon when used during the incubation period of the leukemia process.

Several months after the onset of this disease, the lymphatic structures start to become affected by an inflammatory enlargement process in which the patient shows upon examination, a mass of tumors of different sizes over the cervical, axillary or inguinal regions. Sometimes these enlarged lymphatic structures are located in the abdominal cavity along the path of the mesenteric glands. They explain the reason for the acute abdominal complaint.

The “blood picture,” whether it is taken from the blood or from a bone-marrow puncture, is clearly understood in the typical cases. The increase in the white cells is the predominant factor. However, in the Myelosis type of Leukemia, the white cells are not usually excessive in number.

The blood hemopoietic organs (spleen and liver) are usually involved in the inflammatory process to a marked degree.

The examination of the blood picture has been considered in our times as the primary diagnosis in Leukemia. Unfortunately, however, the disease does not show blood manifestations in the beginning of the attack, and only occasionally are these manifestations apparent in the ultimate stages of the disease (Aleukic Leukemia). It is this particular sector, where the general practitioner should be warned of the abnormal cases of leukemia, in which the repeated examination of blood counts failed to prove any great abnormalities in the leucocyte groups.

In my estimation, the hematological diagnosis in Leukemia is not only based on the QUANITY of the cells but also on the QUALITY. It is concerning this quality problem that Professor Reider explained, years ago, that a typical cell of the white series appears in the blood picture LONG BEFORE a large increase in the rest of the other cells has been established.

Outside of the above clinical manifestations, I would like to call to your attention the frequency of spontaneous bleeding through the buccal cavity (gingival bleeding) with severe or secondary buccal infection and offensive breath. This buccal oral manifestation is sometimes one of the first symptoms in acute cases of Leukemia, and is usually mistaken for localized disease of the buccal cavity.

I would finally like to mention the skin manifestations in the Leukemia disease. They are more or less in the form of a typical rash of small bloody associated with severe skin dryness. Sometimes, these hemorrhagic skin manifestations are under the secundaris dermis in the form of typical hematomas (ecchymosis) of different colors (blue or green) according to their duration. This subcutaneous ecchymosis sometimes extends over the entire body.

With this brief description of the manifestations in Leukemia, let us make an examination of how these patients react under the standard treatments in our practice:

a). Transfusions
b). X-Ray radiations
c). Chemotherapy

The virus in acute cases of leukemia, and is usually mistaken for localized disease of the buccal cavity.

I would finally like to mention the skin manifestations in the leukemia disease. They are more or less in the form of a typical rash of small bloody points associated with severe skin dryness. In some of my clinical cases patients show a record of many transfusions without an apparent change in the hematological picture.

a.) Transfusions:

It is also our experience that chills and increased temperature reactions frequently follow transfusions, clinical expression of red cell crenation by the virus infection. This blood destruction will certainly aggravate the clinical picture of these patients with the waste material of crenated cells recoiled over the spleen structure, and also neutralize the defensive protection mechanism of the hemopoietic system, already impaired by the inflammatory process. In some of my clinical cases, transfusions act as determining factors in the beginning of the bleeding spells.

b.) Deep Therapy Radiation:

The use of deep therapy radiations over the spleen and bone marrow structure is a deplorable technique. After this radiation, chills and fever frequently occur, anemia is also increased and brings down, to a great extent, the patient’s resistance.

c.) Chemotherapy:

Chemotherapy has been used recently in the Philadelphia Children’s Hospital in the experimental stage, basical de Phosphorus radiated and the aminoptherin. The first one is a solution of inorganic phosphorus that has been exposed to X-Ray radiation and given intravenously at intervals of three to five days.

The intravenous radiated phosphorus is a calamitous technique in the treatment of leukemia. This therapeutical action is similar to the deep therapy radiation of the extremities or hemopoietic structures. It is a destructive medication of the normal self-oxidation protective mechanism of the human body.

The ultimate deplorable effect of this medication is impossible to evaluate, because radiation persists in the tissues for many weeks after administration, and certainly neutralizes the beneficial effects of any other measure.

In regard to the aminoptherin (related compound of the folic acid) used as an experimental base in leukemia patients by intravenous dose, we must say it is also a medication which is destructive to the oxidation mechanism of the tissues, as well as a self-depressive medication of the catalytic enzymes. Following this administration, leukopenias are frequently seen, as well as the beginning of decrease in the platelet count.

Hodgkin’s Disease

Hodgkin’s disease, Stenberg disease or Lymphogranuloma is a related hematological disease in which the participation of tuberculosis virus is the main etiological factor.

Like in the Leukemia cases, chills and fever are the first onset of symptoms followed by inflammatory process over the lymphatic structures in the cervical, axillary or inguinal regions.

The chest X-Ray examinations show enlarged lymph glands located along the peri-bronchial structures and pulmonary hilus.

In the blood picture, Hodgkin’s disease patients have a tendency to increase in the eosinophil serial as well as the neutrophil. Anemia is moderated.

As in the Leukemia cases the standard treatments are:

a.) Transfusions
b.) Deep Therapy Radiations
c.) Surgery

a.) The results of transfusions as a treatment of Hodgkin’s disease is only a palliative measure, without benefit or improvement in the clinical manifestations of the disease.
b.) Deep Therapy Radiations over the enlarged lympho-glands and bone marrow structure are also a deplorable technique, with depressive effects upon the oxidation mechanism.
c.) Surgery has been frequently used on these patients, due to the fact that the physical condition of a Hodgkin’s patient is not so deplorable as in Leukemia. Regardless of the skill of the surgical technique and wherever the operation is made, there is a tendency of recurrence of the mass tumor in the months to follow. The disease is systemic, and the local surgical resection will not change the trend of the process.

Among the failures of surgery in Hodgkin’s disease, I would like to show you one outstanding case in my records of a 24-year-old man who was afflicted with lymphogranuloma disease since he was five years of age. The local tumor, of small size in the beginning, was located over the right cervical region (neck region).

From time to time up to the past year he underwent a surgical resection, which scar you can see in his photograph. Following the surgical resection, recurrence takes place to the point of enormous mass tumor on the side of his neck.

The Koch Catalytic Agent in Pulmonary Tuberculosis and Viral Tuberculosis Infection:

On the previous pages, I made a brief examination of the orthodox methods used in the treatment of tuberculosis infection and virus tuberculosis infection, and what to expect from them.

Now, I am going to explain my results and experience with the use of the Koch Catalyst in these two particular diseases; the Pulmonary Tuberculosis and two-virus Tuberculosis Infections: Leukemia and Hodgkin’s disease.

(a) Pulmonary Tuberculosis

We know today that the attempt made by the surgical technique to aid in the recovery of far advanced pulmonary tuberculosis infection has been a failure. Throughout the years, the viewpoint has been somewhat insistently shifted back and forth from the planning of new surgical methods, to studying the action of the old methods.

The tubercular trachea-bronchitis and its pathological complications (bronchial ulcerations and bronchial stenosis) as a result of bronchiogenic spray of the disease are present almost in 75% of patients with cavity formation.

Pulmonary resection in form of total amputation (pneumonectomy) or partial operation (lobectomy) is not a sensible treatment for pulmonary tuberculosis cavities. We know today that the main purpose of these two totally surgical techniques was to solve the problem of “tension cavity” formation.

Pulmonary resection was used years ago by Mosler and Block (1875) as a treatment of pulmonary disease and then dropped as unsatisfactory. In any event, surgical technique failed to solve the complications developed by the disease itself, as well as by the application of methods proved unsatisfactory (thoracoplastics, phrenic resection, pneumothorax, etc.) in tuberculosis practice.

Pulmonary tuberculosis is not a localized disease, and the surgical effort to stall the disease is a failure, as well as would happen if we pretended to save a tubercular ileo-colitis with a total intestinal resection (colectomy).

I am not in favor of the statement made by Dr. Richard Overholt, a leading surgeon in the United States, that a pulmonary resection is a treatment in far advanced pulmonary tuberculosis. Rather than to resect a lung and end the life of a patient, I am in favor of treating the complications, and particularly preventing this complication from developing at the beginning of the disease.

My experiences with the use of carbon Catalytic Agents (Koch) in pulmonary tuberculosis infection should be divided into two separate groups:

(1) Patients in which the “standard therapeutical methods” (orthodox methods) have not been used, and

(2) Patients in which the above methods have been used, and the complications arising from the use of this old conventional system.

Exhibits of these recoveries following the administration of the carbon Catalytic Agents is shown in the following films:

Figure 1. Patient afflicted with right lympho-granuloma tumor in cervical region in which surgery was a total failure. Observe the scar of the operation (arrow).

CASE: Mr. Frank Sacco

Taken November 18, 1944, before Koch Treatment. There is an area of density with multiple cavitations of 1/4 cm. size of honeycombed appearance extending from the first to the fourth interspace. Both apexes are cloudy. Diagnosis: far advanced pulmonary tuberculosis with multiple cavitations.

CASE: Mr. Frank Sacco

Figure 3. Taken on June 1, 1945 after one Koch Treatment. Notice the considerable decrease of density in both pulmonary apexes. Notice the total clarification of density area and multiple cavitations, which were observed in the preceding picture.

CASE: Mr. Vincent Russo

Figure 4. Taken August 20, 1948 before Koch Treatment. Notice the cavity lesion over the right hemi-thorax in the external portion of the second interspace and the increased density of pulmonary hilus.

CASE: Mr. Vincent Russo

Figure 5. Taken August 8, 1944 after one Koch Treatment. Observe the total absorption of pulmonary lesion. The cavity formation observed in the preceding picture has been healed. Pulmonary hilus decreased in density over the right upper pulmonary lobe.

Fig 6. and Fig 7.

CASE: Mrs. Delphin Cook

Figure 6. Taken April 29, 1943 before Koch Treatment. Notice the huge cavity formation over the right hemi-thorax. Notice the small cavity lesion over the external portion of left upper hemi-thorax.

Figure 7. Taken on April 12, 1944 after two Koch injections. The two large cavities observed in the right hemi-thorax have been reduced to a small lesion of cavitarian type. It is very small in comparison with the previous picture. The left pulmonary field is clear.

You have seen the chest X-Ray findings of far advanced pulmonary T.B. infection, and the changes that occurred in these patients following the administration of the Catalytic Agent.

These are illustrative samples, and among my records I have large numbers of similar cases of recoveries. The outstanding feature in this particular recovery is the fact that, in no instance were these patients confined to bed rest, despite the tremendous destructive lesions. That a minimum amount of medication is needed is also an illustrative fact.

MRS. IRENE CASO

CASE: Mrs. Irene Caso

Figure 8. Taken February 23, 1949 before the Koch Treatment. Observe the bi-lateral pulmonary tuberculosis of the cavitarian type is present. Over the right hemi-thorax there is an artificial pneumothorax with 50% of collapse complicated with pleurisy.

CASE: Mrs. Irene Caso

Figure 9. Taken June 15, 1949 after one Koch Treatment. On this picture there are no traces of the fluid formerly seen over the right hemi-thorax. The right lung has been re-expanded. The cavity formation over left hemi-thorax has been healed.

The “second group” consists of complicated cases, and the results obtained under the Catalytic medication include:

(a) Pleurisy
(b) Bacilloscopy or germ sputum
(c) Fibrosis

You have been a witness in the X-Ray findings of far advanced pulmonary tuberculosis infection, with complications arising after the use of orthodox methods; and you have seen the results of recuperation after the administration of the Catalytic Agent. Let us make a brief analysis in regard to the functional symptoms on these above cases. These cases include:

(a) Hemorrhage problems
(b) Bacilloscopy or germ free sputum
(c) Fever
(d) Weight
(e) Sedimentation and blood recovery

The far advanced stage of pulmonary tuberculosis infection is frequently upset with the appearance of profuse respiratory hemorrhage (Hemoptysis). These bleedings occur with violent coughing spells, which the patient cannot control. In any event, the occurrence of these hemorrhages is certainly an unpleasant experience to both the patient and the physician.

Mr. Albert V. Kayser:

CASE: Mr. Albert V. Kayser

Figure 10. Taken January 10, 1944 before the Koch Treatment. There is a right artificial pneumothorax with 50% collapse as a treatment for cavity formation on the same side. Following this pneumo, bi-lateralization takes place, over the contra-lateral lung with cavity formation over the external portion of the third interspace.

CASE: Mr. Albert V. Kayser

Figure 11. Taken February 15, 1945 after one Koch Treatment. Over the right hemi-thorax the lung has been re-expanded after the pneumo was discontinued. Over the left hemi-thorax there is no sign of the cavity formation previously seen.

From the pathological standpoint, Tuberculosis Hemoptysis can be separated into two groups: the true cavitarian hemorrhage which is produced by a rupture of Rasmussen Aneurysms, and the accessory or secondary hemorrhage in which bleeding is a result of ulcerative bronchitis or bronchiectasis below the bronchial stenosis.

The therapeutical value of Catalytic Agents in this particular hemorrhage has been proved very satisfactory in my practice, without the necessity of using any other measure (Vitamin K, sub-cutaneous oxygen, etc.). However, I would now like to explain the necessity of learning the interpretation of hemorrhage in tubercular patients under the Catalytic Solutions as a recovery mechanism.

A hemorrhage as a recovery mechanism, sounds like a paradoxical statement, but we should remember the particular circulatory disturbances in the place of infection (tubercular endo-arteritis) and the participation during the process of tissue repair.

Mr. Raymond Fernandez:

CASE: Mr. Raymond Fernandez

Figure 12. Taken November 17, 1939 before Koch Treatment. Over the right lung, there is obliteration of costo-phrenic angle by a fibrosis process. Notice the Mediastinum shift to the left, with marked fibrosis from the first to the second interspace with probable cavity formation.

CASE: Mr. Raymond Fernandez

Figure 13. Taken December 22, 1940 after one Koch Treatment. The right costo-phrenic angle is clear; the fibrosis process over the left apex has been clarified. Mediastinum displacement of the previous film is not observed this time.

They do not occur systematically in every patient, but when they happen to occur, they follow a periocity law on the 12th or 33rd week after the administration of the Catalytic Agent. They occur with associated complaints of malaise, slight aching all over the body and on occasions, with burning sensations in the chest region. They are short in duration, and are followed by functional and physical improvements.

The physicians should be made familiar with this recovery bleedings, as well as in other pathological conditions (metrorrhagias in patients under recovery from fibroid uterine growth).

The therapeutical value and utility of the Catalyst Solutions in pulmonary hemorrhage, reach a peak of importance, in the particular case of hemorrhage due to ulcerative bronchial stenosis or in the tension cavity problem.

In both pathological conditions, fibrotic tissue is responsible for the failure of results with the use of hemostatic pneumo or by revised thoracoplastics.

The outstanding ability of the carbon Catalyst Agent as a chemical substance with the ability to dissolve fibrotic tissue has been proved to me for many years. In the particular case of pulmonary infection, our chest X-Ray findings prove these results in many instances.

The occurrence of positive sputum in far advanced pulmonary tuberculosis with ulcerations is a logical manifestation of the disease. This germ is not only present over the expectorate material, but also in the feces material (stool elimination) from intestinal ulcerations.

In my experience, the negative sputum is obtained between the seventh and ninth weeks after the Catalyst Agent administration: occasional sporadic recurrence of positive sputum is seen in some of our patients.

A microscopic gross examination of these sputum slides shows interesting facts concerning the increase of the phagocytic cells (neutrophils) and their ability to digest the tubercular bacilli after the administration of the Catalytic Agent. The majority of the tubercular germs are phagocytes and is included in the protoplasm of the above cells with distinctive alterations in their morphology.

The eradication of the tubercular ulcerations, the Catalytic Agent again occupies an important role in the prevention of contagious diseases. The majority of these patients, afflicted with abdominal pains and gastro-intestinal complications in T. B. patients. Again as in chest tuberculosis, the surgeon has attempted to solve this problem with the surgical exclusion of the right colonic segment and direct anastomosis of the terminal ileum to the transverse colon (ileo-transverse-colostomy), but the clinical results proved a total failure as a treatment and eradication of germs from the patient’s stools.

Under the Catalytic Agent, the necessity of surgical approach as a treatment for tubercular intestinal ulcerations loses its importance. Following the administration of the Koch injection, the majority of patients show improvement in their appetites and digest their food easier. Even more important, the amount of free tubercular germ in the stool container decreases considerably, and relieves the absorption into the pulmonary field through the thoracic duct circulation opening in the left sub-clavian vein.

The results of the Catalytic Agent in temperature control in tuberculosis infection are another interesting experience. In the minimal and moderated infection, temperature subsides very rapidly, as a rule, at the end of five days following the first dose. The temperature then becomes normal.

In the far advanced cases (ulceration and cavity type) these results are particularly interesting when a secondary infection has taken place in the cavity formation. This secondary cavity infection in tubercular patients is a dangerous complication with a tendency to weaken the patient’s resistance and develop into the ultimate stages of the tubercular pneumonic process.

From the physio-pathological observation, this secondary cavity infection is produced by a partial or total stenosis of the bronchial cavity drained, and the secondary accumulation of detritus; as well as the increasing virulence of associated bacteria (strep, staphylococcus, etc.), which give violent clinical manifestations with temperatures of 104 and 105 during progressing days.

Before the advent of Streptomycin, the pneumonia process was a serious complication with a high mortality rate of 70% of the patients lost. However, streptomycin therapy and even the Hydro-streptomycin are not free of side effects (vertigo, nausea, dermatitis), and there is also a tendency to a drug resistance strain with secondary increasing in the virulence of other local bacteria.

On the other hand, the majority of these patients are chronic fibroid cases, for whom, experience has proved, streptomycin is not satisfactory.

In my personal experience, the administration of the Catalytic Agent has been proved itself to me as a powerful and effective medication in the control of the tubercular pneumonic process, without the inconvenience of side effect disturbances from the drug preparation. As a rule, temperature subsides gradually between the 72nd hour and five days after the first dose, and subsides into weakness and profuse perspiration.

We shall make some brief comments in regard to the increased weight in tubercular patients under the Catalytic Agent. This weight improvement has been interesting to me due to the fact that the majority of these patients are following a low animal protein diet.

Diet:

The problem of heavy animal protein diet in tubercular patients has been brought to the attention of everyone in the field of tuberculosis practice, not only to the physicians but also to the attention of the general public. The necessity of special care concerning nourishment is brought to attention by the diagnosis of chest tuberculosis. Milk, eggs, and meats are increasing in importance as beneficial foods used to combat gastro-intestinal upset in the majority of these patients.

Normal digestion, in great amounts, produce the accumulation of toxic detritus in the colonic region, with increased formation of toxic amines, and absorption through the portal vein circulation. These highly toxic fermentations not only produce local intestinal disturbances, but also produce a tendency to depress a non-colloidal catalyst (Glutathion), which has the biological function in the liver and muscular tissue essential to the metabolism of lipoids.

A French investigator, Dr. Leon Binett gave us the results of experimentation on animals with a vegetarian diet, the nutritional advantages of this diet over the hemoglobin content and growth, and the gain in weight through the use of the diet.

Carotene extract, when given to these animals previously depressed by a bleeding, increases to a great extent the hemoglobin recovery, Dr. Binett reported.

Yeast preparations have also proved in experimentation to have beneficial results over muscular fatigue, muscular strength, and weight. The majority of yeast preparations are 50% richer than protein elements.

The principle interest in the yeast preparations is the fact that this administration increases the glutathione catalyst level in the bloodstream. For many years, the decrease of the glutathione level in patients afflicted with liver insufficiency has been called to the attention of investigators.

In favor of the benefits of vegetarian diet, two other French investigators, Drs. Pierre Tanrett and Henry Bour of the Societe Medicale Hospitale de Paris, reported in the Journal of Practiciens (NU-1-January, 1942), and later in the review of Phytotherapy, the results obtained in animal experimentations with rich cabbage vegetarian diet.

All the animals under the cabbage regime increased the capillary resistance and showed improvement over the liver insufficiency and dropsy complications. It seems that cabbage preparations (fresh vegetables) are a high potential source of Vitamin C, and perhaps the newly isolated Vitamin P or anti-capillary fragility factor.

For all these reasons, the majority of tubercular sanitariums in the United States have been gradually changing from the animal protein diets. As a result, a large majority of tubercular patients experience considerable relief from intestinal distress without any affect to the increase in their weight.

Finally, let us consider briefly the sedimentation rate and hemogram in T. B. infection under the Catalytic Agent. Some difficulties will arise in the interpretations of this test.

In tuberculosis and many other pathological conditions, when blood coagulations are prevented by adding oxalates or citrates, the red blood cells show a tendency to agglutinate, and fall out of suspension. The speed of sedimentation depends on the degree of agglutination.

An agglutination test in tuberculosis infection is the result of increasing fibrinogen content of plasma, and a decrease in the red cells’ volume. This test is determined, by the electrical potential differences between the negativity charged erythrocytes, and the positively charged plasma.

Any change in the number of red cells, cell volume, or hemoglobin content, on the one hand and changes in the composition of the plasma on the other, will lead to a change in the sedimentation rate.

Reaction Cycles:

The sedimentation rate in our patient is taken, following the Westergren technique, with the reading at one hour, and has been of special value in the interpretation of improvement following the administration of the Catalytic Agent.

A raised sedimentation rate, in absence of any other signs of activity of a tuberculosis lesion, should therefore, lead to a thorough search for some infective focus in a distant part of the body. This concealed tubercular focus site is sure to be exposed by the Catalytic Agent, and among the most frequent of these “distant infective foci” are the ocular manifestations (choroiditis, uveitis, etc.).

Another situation that bears questioning and which has arisen in regard to the normal sedimentation rate (as valuable confirmation of the non-progressive character of tuberculosis lesion), is that during the reactional periods of the Catalytic Agent, an increase occurs systematically and yet is not, in a sense, a manifestation of activity or progress in the pulmonary lesion.

Maisin of Louvain University, Belgium, related years ago that the reactional cycles of the Catalytic Agent are typical allergy manifestations. Therefore, these facts lead us to establish the rule: No laboratory technique should be done during the reactional periods!

The investigation concerning the leucocytes (hemogram) was brought into the clinical field by Arneth in 1904.

The leucocyte picture is of no assistance in the diagnosis of the tuberculous nature of a lesion, but they express, as a mirror, the progress or arrested morbid process of a tubercular patient.

The monocytes lymphocyte ratio has been stressed as an index of healing; in this way, Bredeck’s interpretation is that a high monocytes count indicates a good outlook.

Medlar states that neutrophils play the chief role in the tuberculosis abscess formation, and is a sign of extension of tubercular cavitation.

Kelly, in comparing the leucocyte count with the sedimentation rate in 106 patients, found that the leucocyte count was not as accurate as the sedimentation test.

Crawford, in 1935, established a calculator device known as the ‘Crawford index,’ based on evaluation of the following four factors:

(a) Total white count
(b) Neutrophil
(c) Lymphocyte
(d) Monocytes

He claimed that by this means a better indication is obtained of whether the leucocyte picture is septic, hyperplastic, or non-septic. According to the figure obtained, the index is classified prognostically: increasing unfavorable.

A rise in neutrophils indicates progression and a rise in lymphocytes, indicates resistance, particularly monocytes type. However, patients under the Catalytic Agent, show with frequency marked increases in the eosinophilic cells during the reactionary period.

This eosinophilic increase is related as a typical allergy manifestation, and is also present in T. B. patients with minimal infiltrations (Assman’s transitory faint infiltrations,) as well as follows the administration of Calmette’s vaccination in immunization.

In any event, the Catalytic Agent acts as structural material in which solutions are at a high dilution concentration (1:1.000,000 in Para Benzoquinone). A similar highly diluted solution is also present in all tuberculin material (O.T. or P.P.D.), and is used in our practice for diagnosis purposes and in the immunization material with B.C.G. (Calmette’s vaccination).

In Closing:

The chapter of results obtainable with the Catalytic Agent in pulmonary tuberculosis infection, it will be of great interest to analyze the importance of this material, (Glyoxylide) when it is used as an immunological factor. After all, prophylactic results or prevention in tuberculosis infection has been the main object of every investigator since the discovery of the tubercular bacillus by Robert Koch.

The knowledge and realization of the immunological activity of the Catalytic Agent as a preventive and useful material in tuberculosis infection, is among tubercular families an answer to their prayers for the alleviation of this dreaded disease. Another realization of the utmost importance is of the therapeutic value of the Catalytic Agent, which is now no longer, an experiment.

As in preventive tuberculosis vaccination with the Calmette material, the Koch Concept of the ability and usefulness of the Catalytic Agent as a preventive material in tubercular infection will face, and has been facing, intense opposition from the time he announced his discovery.

As a preventive material, the Koch Catalytic Agent is not a bacteriological substance. The immunological properties acquired with this administration are not a matter of a specific material, or a dangerous material that requires a long period of clinical human experimentation. There is neither a complicated technique of administration, nor is there the absolute necessity that the vaccinated be proved free of tubercular infection (Calmette’s vaccination with B.C.G. an infected children with T.B. familiar medium, is of deleterious effect.)

Why do the Health authorities in the United States not make a survey of Koch’s Catalytic Agents as a prophylactic material in tubercular families, along with Clamette’s foreign material?

I am sure that the use of this Catalytic Agent, among the homes of tubercular families in the United States (with a well and impartial organized survey of results), will give to the Health authorities a powerful weapon of eradication of the tuberculosis infection from this country. Then, we shall no longer see this destructive tuberculosis lesion increasing year by year, into a prevalent ailment which has thus far certainly become a burden to the national economy, and which has necessitated the construction and maintenance of many large institutions.

The immunological activity of the Catalytic Agent in potential tubercular patients is not a specific medication. The injection will increase the immunity ability of the host, and from the viewpoint of the chemist, develop a ‘Natural Immunity,’ far different from the results obtainable in the Calmette bacteriological suspension.

The increasing immunity power acquired by the administration of a chemical material is a well-known fact today. The participation, direct or indirect of different enzymes, which function as a self-catalytic substance, is obtainable following the administration of the Catalytic Agent.

The oxidase-index is a well-established test of the measures of this self-catalyst substance in tubercular patients. The technical procedure of this test has been described by Professor Paoul De Seabra, a Brazilian investigator.

From the therapeutical and immunological value, the Koch Catalytic Agent has proved wonderfully and indubitably its claimed results in pulmonary tuberculosis infection, as a powerful and able medication to restore destructive lesions from the tubercular bacilli even in the ultimate stage of the disease.

Koch’s results in prophylaxis and treatment of pulmonary tuberculosis will stand as an unforgettable monument in our generation, and in the centuries to come.

(b) Viral Tuberculosis

My experience with the use of the Catalytic Agent in virus tuberculosis infection should be separated into two different groups: the leukemia disease and the Hodgkin’s disease.

In order to make this lecture more practical, I will describe case histories, X-Ray findings, and interpretations in one group. This is logical because the clinical manifestations of both leukemia and Hodgkin’s disease are pathologically related. They are equally as well related from the etiological standpoint.

Both diseases are seen by the physician in two different stages: the acute and chronic manifestations.

The acute stage as a result takes place suddenly. The patient, child or adult, complains of severe chills, fever, aching in the extremities, and a typical hematological picture in the last part of the disease. Very unfortunately for the patient’s recovery, the majority of physicians fail to make an early diagnosis of an acute stage, and through this, we are missing a wonderful opportunity to control the infection right in the beginning when the patient’s resistance when pathological damages have not yet been impaired, to any great extent. Typical observation of this nature is the following case.

CASE: Johnny Clements

A five-year-old boy of full term delivery was brought to my office by his parents with history of malaise, high temperatures from 103 to 104 for the past several weeks. This temperature is more persistently active in the evening and on occasions associated with pain in the lower extremities, and accompanied by some headache. Some vomiting spells and a history of frequent chest complaints, particularly a hacking cough without symptoms of a cold are noticed. During the night the fever broke down with profuse perspiration, and there was a lack of appetite and tired sensation during the play hours.

Routine laboratory examinations failed to bring any understanding in this illness; urine sedimentation negative of Pyelitis; blood smear negative of plasmodium malaria, agglutination test for typhus, undulant fever or parathyroid are negative.

Physical examination failed to localize any local infection (tonsilar abscess, otis media, etc.). Spleen and liver were of normal size.

A complete blood count shows slight anemia of 4,000,000 red blood cells with 75% hemoglobin. On the differential, no important changes except slight increase in leucocytes to 8,000, practically normal for a child of this age.

Three years ago, I operated on this child for enlarged lympho-gland infection over the right axillary region. Convalescence was normal and the pathological report on specimen was of no importance.

Two more pathological conditions to be discussed are rheumatic heart fever and polio infection.

A sedimentation test as well as a careful heart examination failed to prove rheumatic child disease. Polio was also ruled out, from the lack of muscular atrophy, or incapacity following the acute onset of symptoms.

A chest X-Ray examination was made and the findings are reported as follows:

Figure 14. Taken before administration of the Koch Treatment. There are enlarged lymph nodes in both pulmonary hilus, more prominent in the right, with typical thin frame inflammatory area arising from the right enlarged nodules. The rest of the pulmonary field is negative.

A final diagnosis of acute virus Leukemia was established, and 2 c.c.’s of the Catalytic Agent was given intramuscularly. A reverse in the pathological trend was obtained in the few weeks to follow; temperature became normal after 5 days. Pain and malaise cleared up very rapidly as well as improvement of the appetite; chest manifestations and frequent colds disappeared in months to follow. The blood count returned to normal erythrocyte formula at the end of three months.

The acute stage of lympho-granuloma disease (Hodgkin) is also difficult to diagnose in the early manifestations, as a rule, the onset of the disease is more or less similar to leukemia cases.

However, the local tumor manifestations and enlarged lymph nodes are more typical in these patients, and the local examination of the tumor (biopsy) as well as the chest X-Ray, make the diagnosis more obtainable.

Figure 15. Taken after administration of the Koch Treatment. The pulmonary field is clear with the exception of enlarged lymph nodes over the right upper mediastinum region and which shadow extends from the first interspace to the second interspace.

Patients in this stage will receive a wonderful benefit from the administration of the Catalytic Agent. The lymphatic enlargement particularly is one of the first symptoms to subside without the necessity of surgery.

Typical observations of this nature are described in the following case:

CASE: Mr. Clifford Swanson, Jr.

An 18-year-old patient was suddenly stricken with high temperature, chills and pains over the extremities. Malaise and weakness followed during the next few days with apparently an enlargement of the cervical glands, painful to palpation.

Figure 15A. Clifford Swanson, Jr., taken after recovery from Hodgkin’s disease following administration of Koch Therapy. A famous Philadelphia Hospital diagnosed his condition and gave him only a few months to live.

He was taken to one of the best hospitals in Philadelphia, Pa., and a biopsy was suggested. The result was a clear diagnosis of lympho-granuloma (Hodgkin’s disease). Deep therapy radiation was advised, as well as surgical resection.

Fortunately for the young man, his father read a scientific lecture one evening, which had been inserted in the Congressional Record by Senator William Langer *, and learned of the results of the Catalytic Medication. Mr. Swanson took his boy to a Detroit Clinic in July 1948, where the first dose of Glyoxylide was given after his physical examination.

*(See the Website’s Table of Contents for a complete copy of this edition of the Congressional Record.)

Following the administration of the Catalytic Agent, the patient’s temperature subsided, and in the next months the cervical gland enlargements decreased to a great extent, with marked relief from pain.

In June 1949, he visited our hospital, First Palma Ceia Hospital, and passed a regular check-up. A chest X-Ray was made at this time. The results are shown here:

There is also some enlargement of the bronchial margin in the right lower pulmonary lobe. The heart structure is normal in position. Costo-phrenic angles are clear.

This patient, C. Swanson, has remained well up to now (August 1949); one year after having been administered the first Glyoxylide dose, and without having suffered any other interference.

(He was observed in December, 1950 and is working everyday.)

Again I would like to remind you of the importance of the chest X-Ray as a diagnostic weapon in lympho-granuloma cases. These above mentioned chest manifestations are undoubtedly manifestations of the virus tubercular infection, and have been observed in my practice for many years in the majority of lympho-granuloma cases.

(c) Chronic Stage of Leukemia

Let us study the chronic stage of Leukemia, which is the most frequent form to appear in general practice. It is in this period that the majority of patients seek the physician.

The chronic stage of leukemia responds in a different manner under the Catalytic Medication, and these changes are dependent on two factors:

(a) Extension of the pathological injury or
(b) Administration of improper medication, depressive and antagonistic to the patient.

Failures in the first group are common when the patient’s condition of toxic manifestations and hematological destructions are so extensive that no recovery is humanly possible.

However, when the patient’s resistance is good and the diagnosis is made in the early stages (chest X-Rays) the recovery under the Catalytic Agent is a frequent occurrence.

Typical of the recovery in this chronic stage are the two following observations:

CASE: Teddy Singletary

An 11-year-old boy, afflicted with lymphatic type leukemia in the past six months, was admitted to our hospital, First Palma Ceia Hospital. The primary examination showed the extremely depressed patient unable to walk by himself. His face showed suffering and freight.

His shortness of breath was very obvious, to the extent that on occasions he was unable to answer any questions. His skin was sallow, and there were bloody, purple spots all over his body. Offensive odors came from his mouth, from which the examination revealed a profuse gingival hemorrhage. Occasionally a temperature of 102 degrees was present in the evenings.

The onset of this manifestation in the mouth and the one of temperature, were acutely in character with manifestations of chills, fever, malaise, severe pain radiated in low extremities, and finally severe anemia with increases leucocytes of the lymphocytic type.

The only therapeutical measure used in this patient had been repeated transfusions (57) in a short period of three months, and with no encouraging results.

Figure 16: A reproduction of the diagnosis made by O. Z. Culler, M.D., of Orangebury, South Carolina, as to the condition of Ted Singletary. Dr. Culler stated that the diagnosis is: “Chronic Leukemia proved by bone marrow biopsy with hemorrhagic diathesis.” Dr. Culler made the diagnosis before Ted Singletary and his family knew of the Koch Treatment.

Figure 17. A clipping from a local newspaper, which is self-explanatory.

Blood count examination at the time of admission was as follows:

Red cells: 2,150,000

Hemoglobin: 40%

Leucocytes: 15,000

The rest of the physical examination showed an enlargement of the spleen, liver structures, and lymphatic glands in the cervical region and groin. Chest examination showed increased tubular respiration in the right pulmonary base, and moist rales over the entire pulmonary field.

Figure 18. Taken of Ted Singletary before receiving the Koch Treatment. The pulmonary field shows cloudiness in both apexes. There are enlarged lymph nodes in both pulmonary hilus, more prominent over the left. Costo-phrenic angles are clear; Mediastinum and heart structure in right position.

After a regular fasting period, 2 c.c.’s of Glyoxylide was given intramuscularly (February 27, 1949), and general care was taken of the oral infection. A week after his admission, he went back home. At the time of his discharge, his temperature was normal, the abdominal distention, particularly in the spleen region, was decreased to a great extent. The enlargement of the cervical glands was also reduced.

The most interesting experience in this recovery mechanism was the rapid absorption of bloody skin patches, which were undergoing a process of absorption and changes in color, from dark blue to light green, yellow, and finally disappeared entirely.

Nine weeks after he had received the one dose of the Catalytic Agent, Glyoxylide, he returned to Tampa for a checkup. At this time, he was able to walk on his own feet, and had gained 12 pounds in weight.

A blood count was as follows: May 5, 1919
Red cells: 3,350,000
Hemoglobin: 52%
Leucocytes: 8,000

A chest X-Ray at the time of his admission into the hospital may be seen in Figure 18.

On May 27, 1949 and exactly in his twelfth week reactional period he complained of epistaxis and some pains in the lower extremities, for which manifestation Vitamin K was administered.

A second checkup was made in our office with the following results:

A blood count was as follows: July 23, 1949
Red cells: 4,000,000
Hemoglobin: 72%
Leucocytes: 6,500

This patient gained 25 pounds from the time of his first admission. He felt good and contemplated returning to his school duties the coming September.

The interesting fact in this recovery mechanism was the fact that no blood transfusions were given and yet his hematological recovery was obtained gradually with increasing value in red cells and hemoglobin, obtainable from healthy regeneration of the bone marrow structures.

This recovery mechanism (hematological repair) did occur immediately. In other words, long before this blood improvement took place, there were manifestations of progress of the functional complaints (weakness, fever, perspiration, appetite, etc.)

In my interpretation, the infection is the first one to be eliminated, which gives hemopoietic structures the ability to take over and re-establish the normal productive blood mechanism, which it is not possible to obtain until the virus is eliminated.

Here is a second recovery observation of chronic lymphatic Leukemia in adult persons.

Figure 19. This is an indoor picture of Ted Singletary and Mrs. J. W. Love.

A member of the staff of The Lutheran Research Society took it in September 1950 during a convention of physicians using Koch Therapy, which was held in Detroit, Michigan. The two recovered Leukemia victims were interviewed at length and appear to be leading perfectly normal lives.

CASE: Mrs. J. W. Love:

A 17-year-old lady came to my office on December 7, 1948, afflicted with Leukemia process well established by her local doctor in Orangeburg, S.C.

Her personal history shows as acute process six months ago, with nausea, chills, fever, and perspiration. These manifestations occurred right after an influenza attack.

After being admitted into my hospital, the rest of the physical examination showed enlarged spleen and liver structures, as well as lymphatic enlargement over cervical region. As in the above case (Teddy) an oral infection was present, with offensive breath and pus pockets over dental structures that required a dentist’s services before she could receive a Treatment.

Dr. Oscar Z. Culler of Orangeburg, S.C. showed the following blood report:
December 13, 1948
Red cells: 3,160,000
Hemoglobin: 57%
Leucocytes: 10,700 Poly: 86%
Lympho: 10%
Mono: 2%
(Myelocytes and pre-myelocytes are present)

As a therapeutical measure she had received from this doctor, two courses of X-Ray over her spleen, long bones and sternum, each course consisting of 600 R at an interval of six weeks.

Following this deep therapy radiation, her condition was no better. Weakness and fever in the evening as well as gingival bleeding spells were present. After her dental problem was solved to a certain extent, she fasted for two days, and on December 13, 1948 one dose of 2 c.c.’s Glyoxylide was given intramuscularly, followed by routine orders.

Due to the fact that she had received intense deep therapy radiation, a second dose was repeated five days from the first one (2 c.c.’s Glyoxylide). She was discharged from the hospital on December 18, 1948.

There are many interesting facts on this patient. One of these facts concerns the moderate increase of the leucocyte myelocyte type. Despite her intense deep therapy radiation where electrical negative charges are reclaimed in the tissues for years to come; her functional manifestations improved very rapidly following the Catalyst administration. Fever was normal at the end of five days; also the chill sensations were normal. The abdomen, the spleen, and the liver were no longer painful to palpation. The oral infection with gingival bleedings had also disappeared.

A blood count made on March 15, 1949 showed the following results:
Red cells: 3,850,000
Hemoglobin: 69%
Leucocytes: 8,500

Up to date, August 5, 1949 she remained well, attending her housekeeping duties, with improvement of 10 pounds in weight and a good appetite.

A third blood count report made on June 16, 1949 showed these results:
Red cells: 4,000,000
Hemoglobin: 72%
Leucocytes: 7,000

In no instance did the above patient receive a single transfusion after the Catalyst Agent was given.

(Mrs. Love was observed in Detroit in September 1950, looking the picture of health.)

You have seen the chest findings and clinical histories of patients with Leukemia in chronic stages of a disease without the interference of improper medication (amintherin, radiated phosphorus, mustard gas, etc.), and how they react following the administration of the Catalytic Agent.

Figure 21:

A reproduction of a blood count report made on Mrs. J. W. Love on May 30, 1550 almost a year after this paper was originally delivered, showing her continued improvement.

CASE: Joe Walley Kay:

A four-year-old boy was admitted to the hospital for lymphatic type of leukemia.

During the past Christmas, feeding in good health, he became ill with severe intercostal neuralgia and high temperature. The pain was so intense that the possibility of rib fracture or injury was thought by his father to be the trouble, but the chest X-Ray was negative.

From the time of onset of his first symptoms, to his admission to my hospital (February 28,1949) his clinical manifestations were similar to previous cases described; malaise, anemia, fever, enlarged lymph nodes, epistaxis, epiderdies, ecchymosis, etc. until the final diagnosis of lymphatic Leukemia was established.

Chest X-Ray was ordered at the time of his admission with the following results:

Figure 22. Picture taken in the fourth month since the onset of the first symptoms. There are enlarged lymph nodes in both pulmonary fields, in the pulmonary hilus, more prominent in the left side. Costo-phrenic angles are clear, Heart, normal in size and position.

The therapeutical measures on this patient were; several transfusions and three doses of radiated phosphorus intravenously given at Philadelphia Children’s Hospital.

After 48 hours of fasting in our hospital, I gave 2 c.c.’s of Glyoxylide intramuscularly, followed by routine orders: ascorbic acid orally and ultra violet radiations.

Blood count was made before receiving his treatment (March 1, 1949) with the following report:
Red cells: 3,900,000
Hemoglobin: 79%
Leucocytes: 5,000 Poly: 38%
Lympho: 61%

Clinical improvement following the first dose of the Catalytic Agent was observed over the enlarged lymph nodes of the cervical region, which decreased in size and tenderness at the end of nine days. The bloody skin spots (ecchymosis) were also very rapidly absorbed. His appetite improved, and the child acted more normal and less irritable.

The outstanding clinical feature in this case was that following the Catalyst dose; no temperature reaction took place, which in my estimation was not a good prognosis. On the other hand, his blood count remained practically the same up to March 14, at which date he was re-admitted to the hospital with a high temperature of 104.

Blood work of March 14, 1949:
Red cells: 3,250,000
Hemoglobin: 59%
Leucocytes: 10,500 Poly: 36%
Lympho: 61%

From March 14 to March 17, 1949 dehydro-Streptomycin was given intramuscularly, a dose of 2 grms. for administration on this fourth day. His temperature returned to normal (95), but his general condition was not good and his blood count was weak.

Blood work: March 21, 1949:
Red cells: 2,850,000
Hemoglobin: 30%
Leucocytes: 9,600 Poly: 40%
Lympho: 57%

He was dismissed from the hospital on March 24, 1949 and went back home. His blood count at the time of dismissal was as follows:

Blood work: March 24,1949:
Red cells: 3,890,000
Hemoglobin: 50%
Leucocytes: 6,800 Poly: 36%
Lympho: 62%

He contracted a severe cold at home and his temperature again increased to 105. Under the care of his family physician, he received some procaine Penicillin. On April 5, 1949 he was re-admitted to the hospital, at my suggestion. On April 6, 1949, a second dose of Glyoxylide was given intramuscularly.

A chest picture was made and showed a consolidation over the left pulmonary lobe, typical of lobar pneumonia.

Despite our efforts, he expired on April 10, 1949. This was a case in which radiated phosphorus was given intramuscularly before he became our patient.

CASE: Miss M. Arthur:

A five-year-old girl was admitted to our hospital afflicted with chronic Leukemia of the lymphatic type. The diagnosis had been established in Lakeland, Florida by a family physician. Until November 1948, she had been a perfectly healthy child. However, at this time, she contracted the measles. After her convalescence, she started complaining of pain in her lower extremities, fever, and chills.

An examination disclosed enlarged lymph nodes over the cervical region and groin. A biopsy was made from one of these glands. The pathological report revealed lymphatic Leukemia.

During the six months of her illness, she had received several transfusions, and intravenous doses of aminotherin without any beneficial results. A chest X-Ray was ordered at the time of admission to our hospital with the following results:

Figure 23. Picture was taken six months from the onset of the symptoms. There are enlarged lymph nodes around both pulmonary hili-costo-phrenic angles are clear. The heart is in normal position.

The rest of the physical examination was similar to the other cases enlarged spleen and liver, multiple bloody spots all over her body. Perhaps the most interesting feature in this patient was the intense severe pain in her extremities, to such an extent that she could not be moved in her bed without severe suffering. The blood count at her admission was as follows:

Blood work: April 23, 1949
Red cells: 2,100,000
Hemoglobin: No figure given
Leucocytes: 9,700 Poly: 19%
Lympho: 81%

After 48 hours of fasting, 2 c.c.’s dose of Catalytic Agent was given intramuscularly. In the following hours, her temperature raised to 102, returning to normal at the end of 72 hours.

Clinical improvement was observed over the enlarged lymph nodes in the cervical region, which became normal in size at the end of five days. She retained food and her appetite improved. The majority of these bloody spots on her skin were absorbed.

The severe pain in her lower extremities subsided, and she was able to move in bed more freely without pain on palpation.

From April 28th to 29th, her condition became worse, with an inability to retain any food, delirium and involuntary control of bowels and bladder followed; she finally expired with heart insufficiency.

SUMMARY and CONCLUSIONS

1. Koch’s Catalytic Agent has passed the stage of experimentation, and its curative value in pulmonary tuberculosis infection is a well-established fact in our day.

2. The prophylactic value of the Catalyst Agent as a preventive medicine in pulmonary T.B., is far superior in results to its near competitor-the B.C.G. vaccination.

3. The immunity acquired with the Catalyst Agent injection in potential tubercular families, is not specific in a sense; it is a result of chemistry of immunity.

4. Beneficial and curative results obtained in viral tuberculosis infection in these two forms: Leukemia and Hodgkin’s disease, have also been recognized. The best results are obtained when treatment is given in the early stage of the disease.

5. The prophylactic value of the Catalyst Agent as a preventive medication in Leukemia and Hodgkin’s disease is well understood, from the moment, that the great majority of these cases in children started the clinical manifestations follow the convalescence from exanthema (measles, chicken-pox, etc.) by which the child’s resistance has been broken down.

6. The necessity and importance of an ‘early diagnosis’ in Leukemia is of tremendous value in the recovery mechanism. Physicians should be ‘leukemia conscious’ as well as they are ‘appendicitis conscious’ in an acute abdomen.

7. The chest X-Ray examination will be of a great help in establishing this early diagnosis. These findings are present long before the blood count shows any abnormalities. (See Figure 24).

8. Any patient afflicted with histories of fever, chills, bloody skin spots or enlarged glands, not explained as a result of other diseases, should be considered a potential tubercular virus host, and a chest X-Ray should be made at once.

9. These clinical manifestations and chest findings are more valuable than the results of local biopsy of a tissue, which on many occasions, have failed to establish an early diagnosis in Leukemia, even in the hands of expert pathologists.

10. Transfusions of a whole blood are no longer necessary in Leukemia patients under the Catalyst Agent. However, in a patient with extremely low blood count (below 2,000,000 with a long history of disease) transfusions should be given as a matter of a ‘supporting measure’ in order to gain time with the Catalyst therapeutic action.

11. In the acute stage of a disease and in small children, my experience in regard to the dosage is as follows: 1 or 1.5 c.c.’s is given at admission and this dose is repeated a second time at the end of five days or at eleven days from the first one. In adults and chronic cases, a full 2 c.c. dose is sometimes sufficient. But if the symptoms do not subside properly, or if the patient has been heavily radiated, a second 2 c.c. dose is repeated at five day or eleven day intervals.