William F. Koch, Ph. D., M. D.

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THE KOCH CATALYTIC AGENTS, BY DR. JULIAN F. BALDOR, M.D. - 1952

Quote from Dow Chemical

“The mere fact that Dr. Koch has a treatment definitely affecting virus diseases is of itself sufficiently important that it ought to be analyzed from every angle by the medical profession. As I understand it, his treatment of the virus type of cancer will run anywhere from 40 to 60 percent cure. If he had 10 percent cure, it would be something the medical men ought to look at, but the ways of the world are strange, and new ideas are slow in developing. I think we all have an opportunity to see something new aborning in Dr. Koch’s work, and it pleases me a great deal to hear about your enthusiasm.” *

* (Quoted from a letter dated June 21, 1946 by Dr. Willard Dow, President, Dow Chemical Company)

Publisher's Forward

It is indeed a pleasure for us to be able to present this volume, “The Koch Catalytic Agents” by Dr. Julius F. Baldor, to the public. This is the third full-scale book, which we have produced on the subject of the Koch Treatment.

The five chapters in Dr. Baldor’s book represent five addresses given by him to groups of physicians who gathered in different parts of the nation over a period of a year and a half to discuss the Koch Treatment and its use in various ailments.

We have tried to connect them together as a unit and herewith submit them in book form. It is important to understand the limitations of attempting to reduce to the printed page what has been given on the lecture platform. Frequently, screen projections were used which we could not reproduce in the text, but to which reference and explanation is made.

Dr. Baldor is, in our opinion, a master at his profession. He is a real teacher. His fluency of language does not lie in the English production found in this book. He was born in Cuba and educated there in his early years. The language of that island so close to our shores is his natural medium. It has been difficult at times to make the text easily understandable in the English idiom, but we have done our best and trust that the content of the material will be of great value to the student of this subject.

Chapter 1: The Catalytic Agents in Tuberculosis Infection and Virus Tuberculosis

OUTLINE

I. Clinical Interpretation of Standard methods in Pulmonary Tuberculosis:

1. Pneumo:

   a. Plural adhesion

   b. Plural effusion

   c. Bilateralization

   d. Fibrosis

2. Thoracoplasty:

   a. Bronchiectasis

   b. Volumetric reduction

   c. Mediastinal displacement

   d. Bilateralization

   e. Tension cavity

3. Chemotherapy:

   a. Gold preparations

   b. Sulfone preparations

   c. Streptomycin

II. Clinical Interpretation of Standard Treatments in Virus Tuberculosis:

1. Leukemia:

   a. Transfusions:

   b. Deep therapy Surgery

   c. Chemotherapy

      1c. Radiate Phosp.

      2c. Aminotherin

      3c. Mustard gas

2. Hodgkin’s Disease:

   a. Transfusions

   b. Deep therapy

   c. Surgery

   d. Chemotherapy

3. Chronic Stage Leukemia:

   a. Case Examples:

      3a. Successful

         I. Teddy Singletary

         II. Mrs. J. W. Love

      3b. Unsuccessful

         I. Joe Walley Kay

         II. Miss M. Arthur

III. Summary and Conclusions

FORWARD

Mr. Chairman, Distinguished Guests;

I wish to express before this assembly a word of dedication to our courageous scientists, Dr. Albert L. Wahl, who sacrificed his life in behalf of humanitarian principles. He was significant as the living cornerstone in our present and future fight against the dark forces of our time. To his memory and his beloved wife, Mrs. Wahl. I respectfully dedicate this small contribution.

The history of tuberculosis infection and its conquest throughout the past years is very interesting indeed. It is very unfortunate, however, that my time is so limited that I will not have the opportunity to elaborate as fully as I would like.

Today we are facing very important facts, which deal particularly with the RESULTS OF RECOVERY in pulmonary tuberculosis infection and in virus tuberculosis infection, through the use of a Catalytic Agent discovered by the outstanding American scientist, Dr. William F. Koch, of Detroit, Michigan.

I want to say, that in the past five years in tuberculosis practice with the Koch Catalytic Agent. I have learned to face more important realities than I had ever expected to encounter. “THE BIRTH OF A SCIENCE,” a 320-page book, which has a large section dedicated to tuberculosis infection, has brought about my realization of how and what has been done for the tuberculosis sufferers. It has more significance to this disease than has an entire library of other celebrated books on the same subject. “THE BIRTH OF A SCIENCE” can be acknowledged as an excellent example of accomplishment and a living lesson useful to the classical system of Sanitarium, so expensive to our taxpayers and national economy.

We must remember the immortal words of Shakespeare: “What custom wills, we must in all things do it, for multitudinous errors would be heaped so high that truth could ne’er o’er pass it.”

Classifications:

This lecture will be a practical one:

The first part will be confined to the analysis of standard methods used by tuberculosis experts in the treatment of pulmonary tuberculosis infection, as well as the results obtained from such methods, and what the general practitioner can expect.

The second part will be confined to the question of virus tuberculosis infection, as an underlying factor in two well-known diseases: the Leukemia process and Hodgkin’s disease or Lymphogranulomatosis, along with clinical interpretations of standard treatments.

The third part gives to us the therapeutical results obtained with the Catalytic Agent in the treatment of pulmonary tuberculosis infection and Hodgkin’s disease.

I. Clinical Interpretation of Standard Methods in Pulmonary Tuberculosis

Patients with pulmonary tuberculosis are truly “infected ones.” For generations, this disease has been considered a contagious type and subject to isolation.

The great majority of tuberculosis specialists direct their remedial measures to the treatment “of the results of the disease,” rather than to the “cause of the disease,” particularly, the tubercular bacilli. Among the results of the disease the following are well known:

a. Cavity Formation
b. Pleurisy
c. Tubercular Bronchial Ulcerations
d. Tubercular Bronchial Stenosis, etc.

Let us go on and make an examination of how these patients react under the “standard” methods, and the complications arising from them.

1.) Pneumothorax (medical collapse)

Professor Amberson of Columbia University (New York) mentioned years ago that of forty qualified patients to collapsotherapy, only 25% showed complete recovery. The remaining 75% have taken the following patterns:

a. Unsatisfactory collapse by Pleural adhesions not susceptible to Pneumonolysis.
b. Pleural effusion of the great pleural cavity, often with secondary infection (emphysema).
c. Spread of the disease to the opposite lung or Bi-lateralization.
d. Fibrosis of parietal or visceral pleura.

2.) Thoracoplasty (surgical collapse)

O’Brien of Boston and Alexander Miller of Bellevue Hospital in New York adopted, years ago, the third and fourth stage operations in thoracoplastic technique, with not more than three ribs to be resected at any stage.

Even with this technical skill, however, complications still develop as follows:

a. Bronchiectasis of the lower lobe with secondary hemorrhage.
b. Volumetric reduction on the affected lung.
c. Mechanical displacements on chest cage structure.
d. Bi-lateralization of disease to the opposite lung from “tension cavity” by a process of back firing. Effect described recently by Dr. Norman J. Wilson on direct bronchoscopic examination.
e. Tension cavity followed by tubercular tracheobronchitis on which most of our knowledge has been acquired by two American investigators: Dr. Richard Overholt and Dr. Gertrude Zilverman.

3.) Chemotherapy

In this section, the standard methods used the most aggressive medications with unfavorable results to the human body and the oxidation mechanism and were highly destructive to the normal physiological process of life. Among them I recall:

a. Gold Preparations

Medication with heavy metals has been extensively used today in arthritis patients. This administration is frequently followed by dermatitis, ocular damage, acute nephritis, and so on…

b. Sulfone preparations (Mayo’s investigators)

In here we found three types of preparations: Promin, Promizole, and Diasone. Any of these are highly destructive to the normal protective mechanism of the reticulo-endothelial system. Following their administration, frequently there occurs severe hematological damage. This is true in the human body as well as in the animal experimentation, according to George H. Higgin’s research, which was published in the Journal of Clinical Pathology (1941).

c. Streptomycin

The active derivative of streptomycin is thought to be the Di-aldehyde-sugar streptose, which by losing one molecule of water, a system of carbonyl ethylene is obtained.

This substance has been the focus of the medical attention in tuberculosis practice for the past ten months. Drs. Feldman, Hinshaw and Mann of the Mayo Foundation and Mayo Clinic started the first experiments with this antibiotic in October 1945.

A year later, Dr. Feldman in collaboration with Dr. Karl Pfuetzer made public a summary of applications in human tuberculosis. In a series of 100 clinical cases, he admitted that streptomycin had beneficial results in “minimal tuberculosis infections,” but in the extensive destructive lesion of cavitation type, streptomycin does not respond well. This also applied to the fibrotic type of tuberculosis.

In my estimation, the lack of activity in a far advanced tuberculosis lesion of the fibrotic ulcerative type is due to local circulatory deficiency. From the pathological standpoint, these far advanced lesions are the ultimate state of obstructive endoarteritis, which circulatory deficiency makes it impossible for the antibiotic to reach the lesion.

The Streptomycin therapy is also facing two more important obstacles: (a.) Its rapid elimination after injection, and (b.) Its inactivation by the increased resistance of the host.

The Streptomycin “fast resistance” not only has the tendency to make this medication hopeless against the infective organism, but also has a tendency to increase the virulence of associated bacteria.

Very recently, Drs. Smith and Feldman made an additional sulfone preparation to the Streptomycin solutions, to overcome this situation of “drug resistance,” but without much success.

I would like to stress a very important fact concerning Streptomycin therapy in pulmonary tuberculosis infection, which is very similar to the effect of the Catalytic Agent in tuberculosis practice. Both medications (Glyoxylide or Streptomycin) produce, when they are injected, a rapid subsiding of the functional symptoms while improvement has not yet been observed in the radiological findings (chest X-Ray). In other words, the functional manifestations subside first, without correlation of the radiological symptoms.

For us who are practicing with the Catalytic Agent, this recovery mechanism is logical, if we remember that the last manifestation to come is the first to go, and the first manifestation to come, is the last to go. This statement-a stroke of genius-was made by Dr. Koch twenty years ago before we dreamed of the advent of Streptomycin therapy in the medical field.

Radiological manifestations in tuberculosis infection are the after effects of the disease, or more properly, the results of the tubercular bacillus infection, whose destructive power has been established over the lung tissue at the beginning of the infective process.

II. Clinical Interpretations of Standard Treatments in Virus Tuberculosis

To any medical student, the history of the tubercular bacilli and its discovery by a German scientist, Robert Koch, is a normal and well understand biological and bacteriological process.

On his birthday, young Koch received a microscope from his wife, Emma Frantz. It was from this time on that Koch began his first steps toward the discovery of the tubercular bacillus, until the moment he presented his paper before the Berlin Physiological Academy; this bacillus had been the bacteriological germ over which the great majority of scientists had spent many tedious and fruitless hours. They had tried to establish new ideas concerning the bacteriological properties of the bacillus and attempted to obtain a vaccine or serum with sufficient power to obtain a cure from the tuberculous infection in the human race.

It is along this path that Dr. Oswaldo Cruz, a distinguished investigator in the Brazilian School of Medicine, made an announcement in 1908. He said that Dr. Fontes, a member of the Institute, had proved the existence of a tubercular virus, which was believed capable of reproducing active tuberculous infection, when a preparation of tubercular bacillus culture was strained through Chamberlain filters.

This historical trend in bacteriological problems with the tubercular bacillus, occupies a definite position in the field of multiple clinical manifestations. I recall two important clinical diseases in which this virus has a direct influence in the development of clinical manifestations, namely, the Leukemia process and Hodgkin’s disease.

Franke and Much call to our attention certain typical granulations of a pseudo-tubercular type found inpatients afflicted with lymphatic leukemia. These granulations are known today as Much Granules and they are considered, also, as a transition in the bacteriology of the tubercular bacillus germ. However, whether or not they are related to the “enzymes group’ is an unanswered question in our day.

Any Hematological textbook considers Leukemia, as well as Hodgkin’s disease, a pathological process in which the tubercular virus is the primary etiological factor. As we did in pulmonary tubercular infection, let us make a brief analysis of the “standard treatments” used in daily practice in leukemia and Hodgkin’s disease.

Clinical manifestations in leukemia are well known to any practical physician. When the patient is in the acute stage, high fever is present. This temperature is not steady as a rule. When it is present, the peak of the temperature occurs in the evening, with chills and fever and sometimes with intestinal complaints. These first symptoms are frequently mistaken for polio infection or rheumatic fever.

Chest manipulations are present in the majority of these cases, with clinical manifestations of coughing with or without severe wheezing which occasionally lasts a few hours. Severe intercostal neuralgia is also present in small children.

The onset of the above manifestations is frequently established following acute exanthema, particularly the measles, in which the child’s resistance has been broken down. The temperature and chills are frequently associated with severe pains along the lower extremities, particularly in the fibula. This situation makes slow progress for weeks and on some occasions the patient is free of disturbances for many years. The blood count is not affected at this time unless perhaps slightly increased in the leucocytes as a manifestation of the virus entrance.

The majority of physicians fail to establish an early diagnosis in this incubation period. In my interpretation, there is one examination of importance that I would like to stress here-the chest X-Ray. The chest X-Ray made in this incubation period always reveals increasing lymph nodes along the pulmonary hilus, and on occasions, transitory atelectasis fields can be seen on these patients from day to day. This atelectasis or transitory stage is the result of enlarged lymph nodes, which put pressure over the medium or large bronchial lumena, and results in clinical manifestations of wheezing.

We have to be conscious of Leukemia in the same manner that we are conscious of appendicitis in an acute abdomen. In my estimation, the chest picture is a certain diagnostic weapon when used during the incubation period of the leukemia process.

Several months after the onset of this disease, the lymphatic structures start to become affected by an inflammatory enlargement process in which the patient shows upon examination, a mass of tumors of different sizes over the cervical, axillary or inguinal regions. Sometimes these enlarged lymphatic structures are located in the abdominal cavity along the path of the mesenteric glands. They explain the reason for the acute abdominal complaint.

The “blood picture,” whether it is taken from the blood or from a bone-marrow puncture, is clearly understood in the typical cases. The increase in the white cells is the predominant factor. However, in the Myelosis type of Leukemia, the white cells are not usually excessive in number.

The blood hemopoietic organs (spleen and liver) are usually involved in the inflammatory process to a marked degree.

The examination of the blood picture has been considered in our times as the primary diagnosis in Leukemia. Unfortunately, however, the disease does not show blood manifestations in the beginning of the attack, and only occasionally are these manifestations apparent in the ultimate stages of the disease (Aleukic Leukemia). It is this particular sector, where the general practitioner should be warned of the abnormal cases of leukemia, in which the repeated examination of blood counts failed to prove any great abnormalities in the leucocyte groups.

In my estimation, the hematological diagnosis in Leukemia is not only based on the QUANITY of the cells but also on the QUALITY. It is concerning this quality problem that Professor Reider explained, years ago, that a typical cell of the white series appears in the blood picture LONG BEFORE a large increase in the rest of the other cells has been established.

Outside of the above clinical manifestations, I would like to call to your attention the frequency of spontaneous bleeding through the buccal cavity (gingival bleeding) with severe or secondary buccal infection and offensive breath. This buccal oral manifestation is sometimes one of the first symptoms in acute cases of Leukemia, and is usually mistaken for localized disease of the buccal cavity.

I would finally like to mention the skin manifestations in the Leukemia disease. They are more or less in the form of a typical rash of small bloody associated with severe skin dryness. Sometimes, these hemorrhagic skin manifestations are under the secundaris dermis in the form of typical hematomas (ecchymosis) of different colors (blue or green) according to their duration. This subcutaneous ecchymosis sometimes extends over the entire body.

With this brief description of the manifestations in Leukemia, let us make an examination of how these patients react under the standard treatments in our practice:

a). Transfusions
b). X-Ray radiations
c). Chemotherapy

The virus in acute cases of leukemia, and is usually mistaken for localized disease of the buccal cavity.

I would finally like to mention the skin manifestations in the leukemia disease. They are more or less in the form of a typical rash of small bloody points associated with severe skin dryness. In some of my clinical cases patients show a record of many transfusions without an apparent change in the hematological picture.

a.) Transfusions:

It is also our experience that chills and increased temperature reactions frequently follow transfusions, clinical expression of red cell crenation by the virus infection. This blood destruction will certainly aggravate the clinical picture of these patients with the waste material of crenated cells recoiled over the spleen structure, and also neutralize the defensive protection mechanism of the hemopoietic system, already impaired by the inflammatory process. In some of my clinical cases, transfusions act as determining factors in the beginning of the bleeding spells.

b.) Deep Therapy Radiation:

The use of deep therapy radiations over the spleen and bone marrow structure is a deplorable technique. After this radiation, chills and fever frequently occur, anemia is also increased and brings down, to a great extent, the patient’s resistance.

c.) Chemotherapy:

Chemotherapy has been used recently in the Philadelphia Children’s Hospital in the experimental stage, basical de Phosphorus radiated and the aminoptherin. The first one is a solution of inorganic phosphorus that has been exposed to X-Ray radiation and given intravenously at intervals of three to five days.

The intravenous radiated phosphorus is a calamitous technique in the treatment of leukemia. This therapeutical action is similar to the deep therapy radiation of the extremities or hemopoietic structures. It is a destructive medication of the normal self-oxidation protective mechanism of the human body.

The ultimate deplorable effect of this medication is impossible to evaluate, because radiation persists in the tissues for many weeks after administration, and certainly neutralizes the beneficial effects of any other measure.

In regard to the aminoptherin (related compound of the folic acid) used as an experimental base in leukemia patients by intravenous dose, we must say it is also a medication which is destructive to the oxidation mechanism of the tissues, as well as a self-depressive medication of the catalytic enzymes. Following this administration, leukopenias are frequently seen, as well as the beginning of decrease in the platelet count.

Hodgkin’s Disease

Hodgkin’s disease, Stenberg disease or Lymphogranuloma is a related hematological disease in which the participation of tuberculosis virus is the main etiological factor.

Like in the Leukemia cases, chills and fever are the first onset of symptoms followed by inflammatory process over the lymphatic structures in the cervical, axillary or inguinal regions.

The chest X-Ray examinations show enlarged lymph glands located along the peri-bronchial structures and pulmonary hilus.

In the blood picture, Hodgkin’s disease patients have a tendency to increase in the eosinophil serial as well as the neutrophil. Anemia is moderated.

As in the Leukemia cases the standard treatments are:

a.) Transfusions
b.) Deep Therapy Radiations
c.) Surgery

a.) The results of transfusions as a treatment of Hodgkin’s disease is only a palliative measure, without benefit or improvement in the clinical manifestations of the disease.
b.) Deep Therapy Radiations over the enlarged lympho-glands and bone marrow structure are also a deplorable technique, with depressive effects upon the oxidation mechanism.
c.) Surgery has been frequently used on these patients, due to the fact that the physical condition of a Hodgkin’s patient is not so deplorable as in Leukemia. Regardless of the skill of the surgical technique and wherever the operation is made, there is a tendency of recurrence of the mass tumor in the months to follow. The disease is systemic, and the local surgical resection will not change the trend of the process.

Among the failures of surgery in Hodgkin’s disease, I would like to show you one outstanding case in my records of a 24-year-old man who was afflicted with lymphogranuloma disease since he was five years of age. The local tumor, of small size in the beginning, was located over the right cervical region (neck region).

From time to time up to the past year he underwent a surgical resection, which scar you can see in his photograph. Following the surgical resection, recurrence takes place to the point of enormous mass tumor on the side of his neck.

The Koch Catalytic Agent in Pulmonary Tuberculosis and Viral Tuberculosis Infection:

On the previous pages, I made a brief examination of the orthodox methods used in the treatment of tuberculosis infection and virus tuberculosis infection, and what to expect from them.

Now, I am going to explain my results and experience with the use of the Koch Catalyst in these two particular diseases; the Pulmonary Tuberculosis and two-virus Tuberculosis Infections: Leukemia and Hodgkin’s disease.

(a) Pulmonary Tuberculosis

We know today that the attempt made by the surgical technique to aid in the recovery of far advanced pulmonary tuberculosis infection has been a failure. Throughout the years, the viewpoint has been somewhat insistently shifted back and forth from the planning of new surgical methods, to studying the action of the old methods.

The tubercular trachea-bronchitis and its pathological complications (bronchial ulcerations and bronchial stenosis) as a result of bronchiogenic spray of the disease are present almost in 75% of patients with cavity formation.

Pulmonary resection in form of total amputation (pneumonectomy) or partial operation (lobectomy) is not a sensible treatment for pulmonary tuberculosis cavities. We know today that the main purpose of these two totally surgical techniques was to solve the problem of “tension cavity” formation.

Pulmonary resection was used years ago by Mosler and Block (1875) as a treatment of pulmonary disease and then dropped as unsatisfactory. In any event, surgical technique failed to solve the complications developed by the disease itself, as well as by the application of methods proved unsatisfactory (thoracoplastics, phrenic resection, pneumothorax, etc.) in tuberculosis practice.

Pulmonary tuberculosis is not a localized disease, and the surgical effort to stall the disease is a failure, as well as would happen if we pretended to save a tubercular ileo-colitis with a total intestinal resection (colectomy).

I am not in favor of the statement made by Dr. Richard Overholt, a leading surgeon in the United States, that a pulmonary resection is a treatment in far advanced pulmonary tuberculosis. Rather than to resect a lung and end the life of a patient, I am in favor of treating the complications, and particularly preventing this complication from developing at the beginning of the disease.

My experiences with the use of carbon Catalytic Agents (Koch) in pulmonary tuberculosis infection should be divided into two separate groups:

(1) Patients in which the “standard therapeutical methods” (orthodox methods) have not been used, and

(2) Patients in which the above methods have been used, and the complications arising from the use of this old conventional system.

Exhibits of these recoveries following the administration of the carbon Catalytic Agents is shown in the following films:

Figure 1. Patient afflicted with right lympho-granuloma tumor in cervical region in which surgery was a total failure. Observe the scar of the operation (arrow).

CASE: Mr. Frank Sacco

Taken November 18, 1944, before Koch Treatment. There is an area of density with multiple cavitations of 1/4 cm. size of honeycombed appearance extending from the first to the fourth interspace. Both apexes are cloudy. Diagnosis: far advanced pulmonary tuberculosis with multiple cavitations.

CASE: Mr. Frank Sacco

Figure 3. Taken on June 1, 1945 after one Koch Treatment. Notice the considerable decrease of density in both pulmonary apexes. Notice the total clarification of density area and multiple cavitations, which were observed in the preceding picture.

CASE: Mr. Vincent Russo

Figure 4. Taken August 20, 1948 before Koch Treatment. Notice the cavity lesion over the right hemi-thorax in the external portion of the second interspace and the increased density of pulmonary hilus.

CASE: Mr. Vincent Russo

Figure 5. Taken August 8, 1944 after one Koch Treatment. Observe the total absorption of pulmonary lesion. The cavity formation observed in the preceding picture has been healed. Pulmonary hilus decreased in density over the right upper pulmonary lobe.

Fig 6. and Fig 7.

CASE: Mrs. Delphin Cook

Figure 6. Taken April 29, 1943 before Koch Treatment. Notice the huge cavity formation over the right hemi-thorax. Notice the small cavity lesion over the external portion of left upper hemi-thorax.

Figure 7. Taken on April 12, 1944 after two Koch injections. The two large cavities observed in the right hemi-thorax have been reduced to a small lesion of cavitarian type. It is very small in comparison with the previous picture. The left pulmonary field is clear.

You have seen the chest X-Ray findings of far advanced pulmonary T.B. infection, and the changes that occurred in these patients following the administration of the Catalytic Agent.

These are illustrative samples, and among my records I have large numbers of similar cases of recoveries. The outstanding feature in this particular recovery is the fact that, in no instance were these patients confined to bed rest, despite the tremendous destructive lesions. That a minimum amount of medication is needed is also an illustrative fact.

MRS. IRENE CASO

CASE: Mrs. Irene Caso

Figure 8. Taken February 23, 1949 before the Koch Treatment. Observe the bi-lateral pulmonary tuberculosis of the cavitarian type is present. Over the right hemi-thorax there is an artificial pneumothorax with 50% of collapse complicated with pleurisy.

CASE: Mrs. Irene Caso

Figure 9. Taken June 15, 1949 after one Koch Treatment. On this picture there are no traces of the fluid formerly seen over the right hemi-thorax. The right lung has been re-expanded. The cavity formation over left hemi-thorax has been healed.

The “second group” consists of complicated cases, and the results obtained under the Catalytic medication include:

(a) Pleurisy
(b) Bacilloscopy or germ sputum
(c) Fibrosis

You have been a witness in the X-Ray findings of far advanced pulmonary tuberculosis infection, with complications arising after the use of orthodox methods; and you have seen the results of recuperation after the administration of the Catalytic Agent. Let us make a brief analysis in regard to the functional symptoms on these above cases. These cases include:

(a) Hemorrhage problems
(b) Bacilloscopy or germ free sputum
(c) Fever
(d) Weight
(e) Sedimentation and blood recovery

The far advanced stage of pulmonary tuberculosis infection is frequently upset with the appearance of profuse respiratory hemorrhage (Hemoptysis). These bleedings occur with violent coughing spells, which the patient cannot control. In any event, the occurrence of these hemorrhages is certainly an unpleasant experience to both the patient and the physician.

Mr. Albert V. Kayser:

CASE: Mr. Albert V. Kayser

Figure 10. Taken January 10, 1944 before the Koch Treatment. There is a right artificial pneumothorax with 50% collapse as a treatment for cavity formation on the same side. Following this pneumo, bi-lateralization takes place, over the contra-lateral lung with cavity formation over the external portion of the third interspace.

CASE: Mr. Albert V. Kayser

Figure 11. Taken February 15, 1945 after one Koch Treatment. Over the right hemi-thorax the lung has been re-expanded after the pneumo was discontinued. Over the left hemi-thorax there is no sign of the cavity formation previously seen.

From the pathological standpoint, Tuberculosis Hemoptysis can be separated into two groups: the true cavitarian hemorrhage which is produced by a rupture of Rasmussen Aneurysms, and the accessory or secondary hemorrhage in which bleeding is a result of ulcerative bronchitis or bronchiectasis below the bronchial stenosis.

The therapeutical value of Catalytic Agents in this particular hemorrhage has been proved very satisfactory in my practice, without the necessity of using any other measure (Vitamin K, sub-cutaneous oxygen, etc.). However, I would now like to explain the necessity of learning the interpretation of hemorrhage in tubercular patients under the Catalytic Solutions as a recovery mechanism.

A hemorrhage as a recovery mechanism, sounds like a paradoxical statement, but we should remember the particular circulatory disturbances in the place of infection (tubercular endo-arteritis) and the participation during the process of tissue repair.

Mr. Raymond Fernandez:

CASE: Mr. Raymond Fernandez

Figure 12. Taken November 17, 1939 before Koch Treatment. Over the right lung, there is obliteration of costo-phrenic angle by a fibrosis process. Notice the Mediastinum shift to the left, with marked fibrosis from the first to the second interspace with probable cavity formation.

CASE: Mr. Raymond Fernandez

Figure 13. Taken December 22, 1940 after one Koch Treatment. The right costo-phrenic angle is clear; the fibrosis process over the left apex has been clarified. Mediastinum displacement of the previous film is not observed this time.

They do not occur systematically in every patient, but when they happen to occur, they follow a periocity law on the 12th or 33rd week after the administration of the Catalytic Agent. They occur with associated complaints of malaise, slight aching all over the body and on occasions, with burning sensations in the chest region. They are short in duration, and are followed by functional and physical improvements.

The physicians should be made familiar with this recovery bleedings, as well as in other pathological conditions (metrorrhagias in patients under recovery from fibroid uterine growth).

The therapeutical value and utility of the Catalyst Solutions in pulmonary hemorrhage, reach a peak of importance, in the particular case of hemorrhage due to ulcerative bronchial stenosis or in the tension cavity problem.

In both pathological conditions, fibrotic tissue is responsible for the failure of results with the use of hemostatic pneumo or by revised thoracoplastics.

The outstanding ability of the carbon Catalyst Agent as a chemical substance with the ability to dissolve fibrotic tissue has been proved to me for many years. In the particular case of pulmonary infection, our chest X-Ray findings prove these results in many instances.

The occurrence of positive sputum in far advanced pulmonary tuberculosis with ulcerations is a logical manifestation of the disease. This germ is not only present over the expectorate material, but also in the feces material (stool elimination) from intestinal ulcerations.

In my experience, the negative sputum is obtained between the seventh and ninth weeks after the Catalyst Agent administration: occasional sporadic recurrence of positive sputum is seen in some of our patients.

A microscopic gross examination of these sputum slides shows interesting facts concerning the increase of the phagocytic cells (neutrophils) and their ability to digest the tubercular bacilli after the administration of the Catalytic Agent. The majority of the tubercular germs are phagocytes and is included in the protoplasm of the above cells with distinctive alterations in their morphology.

The eradication of the tubercular ulcerations, the Catalytic Agent again occupies an important role in the prevention of contagious diseases. The majority of these patients, afflicted with abdominal pains and gastro-intestinal complications in T. B. patients. Again as in chest tuberculosis, the surgeon has attempted to solve this problem with the surgical exclusion of the right colonic segment and direct anastomosis of the terminal ileum to the transverse colon (ileo-transverse-colostomy), but the clinical results proved a total failure as a treatment and eradication of germs from the patient’s stools.

Under the Catalytic Agent, the necessity of surgical approach as a treatment for tubercular intestinal ulcerations loses its importance. Following the administration of the Koch injection, the majority of patients show improvement in their appetites and digest their food easier. Even more important, the amount of free tubercular germ in the stool container decreases considerably, and relieves the absorption into the pulmonary field through the thoracic duct circulation opening in the left sub-clavian vein.

The results of the Catalytic Agent in temperature control in tuberculosis infection are another interesting experience. In the minimal and moderated infection, temperature subsides very rapidly, as a rule, at the end of five days following the first dose. The temperature then becomes normal.

In the far advanced cases (ulceration and cavity type) these results are particularly interesting when a secondary infection has taken place in the cavity formation. This secondary cavity infection in tubercular patients is a dangerous complication with a tendency to weaken the patient’s resistance and develop into the ultimate stages of the tubercular pneumonic process.

From the physio-pathological observation, this secondary cavity infection is produced by a partial or total stenosis of the bronchial cavity drained, and the secondary accumulation of detritus; as well as the increasing virulence of associated bacteria (strep, staphylococcus, etc.), which give violent clinical manifestations with temperatures of 104 and 105 during progressing days.

Before the advent of Streptomycin, the pneumonia process was a serious complication with a high mortality rate of 70% of the patients lost. However, streptomycin therapy and even the Hydro-streptomycin are not free of side effects (vertigo, nausea, dermatitis), and there is also a tendency to a drug resistance strain with secondary increasing in the virulence of other local bacteria.

On the other hand, the majority of these patients are chronic fibroid cases, for whom, experience has proved, streptomycin is not satisfactory.

In my personal experience, the administration of the Catalytic Agent has been proved itself to me as a powerful and effective medication in the control of the tubercular pneumonic process, without the inconvenience of side effect disturbances from the drug preparation. As a rule, temperature subsides gradually between the 72nd hour and five days after the first dose, and subsides into weakness and profuse perspiration.

We shall make some brief comments in regard to the increased weight in tubercular patients under the Catalytic Agent. This weight improvement has been interesting to me due to the fact that the majority of these patients are following a low animal protein diet.

Diet:

The problem of heavy animal protein diet in tubercular patients has been brought to the attention of everyone in the field of tuberculosis practice, not only to the physicians but also to the attention of the general public. The necessity of special care concerning nourishment is brought to attention by the diagnosis of chest tuberculosis. Milk, eggs, and meats are increasing in importance as beneficial foods used to combat gastro-intestinal upset in the majority of these patients.

Normal digestion, in great amounts, produce the accumulation of toxic detritus in the colonic region, with increased formation of toxic amines, and absorption through the portal vein circulation. These highly toxic fermentations not only produce local intestinal disturbances, but also produce a tendency to depress a non-colloidal catalyst (Glutathion), which has the biological function in the liver and muscular tissue essential to the metabolism of lipoids.

A French investigator, Dr. Leon Binett gave us the results of experimentation on animals with a vegetarian diet, the nutritional advantages of this diet over the hemoglobin content and growth, and the gain in weight through the use of the diet.

Carotene extract, when given to these animals previously depressed by a bleeding, increases to a great extent the hemoglobin recovery, Dr. Binett reported.

Yeast preparations have also proved in experimentation to have beneficial results over muscular fatigue, muscular strength, and weight. The majority of yeast preparations are 50% richer than protein elements.

The principle interest in the yeast preparations is the fact that this administration increases the glutathione catalyst level in the bloodstream. For many years, the decrease of the glutathione level in patients afflicted with liver insufficiency has been called to the attention of investigators.

In favor of the benefits of vegetarian diet, two other French investigators, Drs. Pierre Tanrett and Henry Bour of the Societe Medicale Hospitale de Paris, reported in the Journal of Practiciens (NU-1-January, 1942), and later in the review of Phytotherapy, the results obtained in animal experimentations with rich cabbage vegetarian diet.

All the animals under the cabbage regime increased the capillary resistance and showed improvement over the liver insufficiency and dropsy complications. It seems that cabbage preparations (fresh vegetables) are a high potential source of Vitamin C, and perhaps the newly isolated Vitamin P or anti-capillary fragility factor.

For all these reasons, the majority of tubercular sanitariums in the United States have been gradually changing from the animal protein diets. As a result, a large majority of tubercular patients experience considerable relief from intestinal distress without any affect to the increase in their weight.

Finally, let us consider briefly the sedimentation rate and hemogram in T. B. infection under the Catalytic Agent. Some difficulties will arise in the interpretations of this test.

In tuberculosis and many other pathological conditions, when blood coagulations are prevented by adding oxalates or citrates, the red blood cells show a tendency to agglutinate, and fall out of suspension. The speed of sedimentation depends on the degree of agglutination.

An agglutination test in tuberculosis infection is the result of increasing fibrinogen content of plasma, and a decrease in the red cells’ volume. This test is determined, by the electrical potential differences between the negativity charged erythrocytes, and the positively charged plasma.

Any change in the number of red cells, cell volume, or hemoglobin content, on the one hand and changes in the composition of the plasma on the other, will lead to a change in the sedimentation rate.

Reaction Cycles:

The sedimentation rate in our patient is taken, following the Westergren technique, with the reading at one hour, and has been of special value in the interpretation of improvement following the administration of the Catalytic Agent.

A raised sedimentation rate, in absence of any other signs of activity of a tuberculosis lesion, should therefore, lead to a thorough search for some infective focus in a distant part of the body. This concealed tubercular focus site is sure to be exposed by the Catalytic Agent, and among the most frequent of these “distant infective foci” are the ocular manifestations (choroiditis, uveitis, etc.).

Another situation that bears questioning and which has arisen in regard to the normal sedimentation rate (as valuable confirmation of the non-progressive character of tuberculosis lesion), is that during the reactional periods of the Catalytic Agent, an increase occurs systematically and yet is not, in a sense, a manifestation of activity or progress in the pulmonary lesion.

Maisin of Louvain University, Belgium, related years ago that the reactional cycles of the Catalytic Agent are typical allergy manifestations. Therefore, these facts lead us to establish the rule: No laboratory technique should be done during the reactional periods!

The investigation concerning the leucocytes (hemogram) was brought into the clinical field by Arneth in 1904.

The leucocyte picture is of no assistance in the diagnosis of the tuberculous nature of a lesion, but they express, as a mirror, the progress or arrested morbid process of a tubercular patient.

The monocytes lymphocyte ratio has been stressed as an index of healing; in this way, Bredeck’s interpretation is that a high monocytes count indicates a good outlook.

Medlar states that neutrophils play the chief role in the tuberculosis abscess formation, and is a sign of extension of tubercular cavitation.

Kelly, in comparing the leucocyte count with the sedimentation rate in 106 patients, found that the leucocyte count was not as accurate as the sedimentation test.

Crawford, in 1935, established a calculator device known as the ‘Crawford index,’ based on evaluation of the following four factors:

(a) Total white count
(b) Neutrophil
(c) Lymphocyte
(d) Monocytes

He claimed that by this means a better indication is obtained of whether the leucocyte picture is septic, hyperplastic, or non-septic. According to the figure obtained, the index is classified prognostically: increasing unfavorable.

A rise in neutrophils indicates progression and a rise in lymphocytes, indicates resistance, particularly monocytes type. However, patients under the Catalytic Agent, show with frequency marked increases in the eosinophilic cells during the reactionary period.

This eosinophilic increase is related as a typical allergy manifestation, and is also present in T. B. patients with minimal infiltrations (Assman’s transitory faint infiltrations,) as well as follows the administration of Calmette’s vaccination in immunization.

In any event, the Catalytic Agent acts as structural material in which solutions are at a high dilution concentration (1:1.000,000 in Para Benzoquinone). A similar highly diluted solution is also present in all tuberculin material (O.T. or P.P.D.), and is used in our practice for diagnosis purposes and in the immunization material with B.C.G. (Calmette’s vaccination).

In Closing:

The chapter of results obtainable with the Catalytic Agent in pulmonary tuberculosis infection, it will be of great interest to analyze the importance of this material, (Glyoxylide) when it is used as an immunological factor. After all, prophylactic results or prevention in tuberculosis infection has been the main object of every investigator since the discovery of the tubercular bacillus by Robert Koch.

The knowledge and realization of the immunological activity of the Catalytic Agent as a preventive and useful material in tuberculosis infection, is among tubercular families an answer to their prayers for the alleviation of this dreaded disease. Another realization of the utmost importance is of the therapeutic value of the Catalytic Agent, which is now no longer, an experiment.

As in preventive tuberculosis vaccination with the Calmette material, the Koch Concept of the ability and usefulness of the Catalytic Agent as a preventive material in tubercular infection will face, and has been facing, intense opposition from the time he announced his discovery.

As a preventive material, the Koch Catalytic Agent is not a bacteriological substance. The immunological properties acquired with this administration are not a matter of a specific material, or a dangerous material that requires a long period of clinical human experimentation. There is neither a complicated technique of administration, nor is there the absolute necessity that the vaccinated be proved free of tubercular infection (Calmette’s vaccination with B.C.G. an infected children with T.B. familiar medium, is of deleterious effect.)

Why do the Health authorities in the United States not make a survey of Koch’s Catalytic Agents as a prophylactic material in tubercular families, along with Clamette’s foreign material?

I am sure that the use of this Catalytic Agent, among the homes of tubercular families in the United States (with a well and impartial organized survey of results), will give to the Health authorities a powerful weapon of eradication of the tuberculosis infection from this country. Then, we shall no longer see this destructive tuberculosis lesion increasing year by year, into a prevalent ailment which has thus far certainly become a burden to the national economy, and which has necessitated the construction and maintenance of many large institutions.

The immunological activity of the Catalytic Agent in potential tubercular patients is not a specific medication. The injection will increase the immunity ability of the host, and from the viewpoint of the chemist, develop a ‘Natural Immunity,’ far different from the results obtainable in the Calmette bacteriological suspension.

The increasing immunity power acquired by the administration of a chemical material is a well-known fact today. The participation, direct or indirect of different enzymes, which function as a self-catalytic substance, is obtainable following the administration of the Catalytic Agent.

The oxidase-index is a well-established test of the measures of this self-catalyst substance in tubercular patients. The technical procedure of this test has been described by Professor Paoul De Seabra, a Brazilian investigator.

From the therapeutical and immunological value, the Koch Catalytic Agent has proved wonderfully and indubitably its claimed results in pulmonary tuberculosis infection, as a powerful and able medication to restore destructive lesions from the tubercular bacilli even in the ultimate stage of the disease.

Koch’s results in prophylaxis and treatment of pulmonary tuberculosis will stand as an unforgettable monument in our generation, and in the centuries to come.

(b) Viral Tuberculosis

My experience with the use of the Catalytic Agent in virus tuberculosis infection should be separated into two different groups: the leukemia disease and the Hodgkin’s disease.

In order to make this lecture more practical, I will describe case histories, X-Ray findings, and interpretations in one group. This is logical because the clinical manifestations of both leukemia and Hodgkin’s disease are pathologically related. They are equally as well related from the etiological standpoint.

Both diseases are seen by the physician in two different stages: the acute and chronic manifestations.

The acute stage as a result takes place suddenly. The patient, child or adult, complains of severe chills, fever, aching in the extremities, and a typical hematological picture in the last part of the disease. Very unfortunately for the patient’s recovery, the majority of physicians fail to make an early diagnosis of an acute stage, and through this, we are missing a wonderful opportunity to control the infection right in the beginning when the patient’s resistance when pathological damages have not yet been impaired, to any great extent. Typical observation of this nature is the following case.

CASE: Johnny Clements

A five-year-old boy of full term delivery was brought to my office by his parents with history of malaise, high temperatures from 103 to 104 for the past several weeks. This temperature is more persistently active in the evening and on occasions associated with pain in the lower extremities, and accompanied by some headache. Some vomiting spells and a history of frequent chest complaints, particularly a hacking cough without symptoms of a cold are noticed. During the night the fever broke down with profuse perspiration, and there was a lack of appetite and tired sensation during the play hours.

Routine laboratory examinations failed to bring any understanding in this illness; urine sedimentation negative of Pyelitis; blood smear negative of plasmodium malaria, agglutination test for typhus, undulant fever or parathyroid are negative.

Physical examination failed to localize any local infection (tonsilar abscess, otis media, etc.). Spleen and liver were of normal size.

A complete blood count shows slight anemia of 4,000,000 red blood cells with 75% hemoglobin. On the differential, no important changes except slight increase in leucocytes to 8,000, practically normal for a child of this age.

Three years ago, I operated on this child for enlarged lympho-gland infection over the right axillary region. Convalescence was normal and the pathological report on specimen was of no importance.

Two more pathological conditions to be discussed are rheumatic heart fever and polio infection.

A sedimentation test as well as a careful heart examination failed to prove rheumatic child disease. Polio was also ruled out, from the lack of muscular atrophy, or incapacity following the acute onset of symptoms.

A chest X-Ray examination was made and the findings are reported as follows:

Figure 14. Taken before administration of the Koch Treatment. There are enlarged lymph nodes in both pulmonary hilus, more prominent in the right, with typical thin frame inflammatory area arising from the right enlarged nodules. The rest of the pulmonary field is negative.

A final diagnosis of acute virus Leukemia was established, and 2 c.c.’s of the Catalytic Agent was given intramuscularly. A reverse in the pathological trend was obtained in the few weeks to follow; temperature became normal after 5 days. Pain and malaise cleared up very rapidly as well as improvement of the appetite; chest manifestations and frequent colds disappeared in months to follow. The blood count returned to normal erythrocyte formula at the end of three months.

The acute stage of lympho-granuloma disease (Hodgkin) is also difficult to diagnose in the early manifestations, as a rule, the onset of the disease is more or less similar to leukemia cases.

However, the local tumor manifestations and enlarged lymph nodes are more typical in these patients, and the local examination of the tumor (biopsy) as well as the chest X-Ray, make the diagnosis more obtainable.

Figure 15. Taken after administration of the Koch Treatment. The pulmonary field is clear with the exception of enlarged lymph nodes over the right upper mediastinum region and which shadow extends from the first interspace to the second interspace.

Patients in this stage will receive a wonderful benefit from the administration of the Catalytic Agent. The lymphatic enlargement particularly is one of the first symptoms to subside without the necessity of surgery.

Typical observations of this nature are described in the following case:

CASE: Mr. Clifford Swanson, Jr.

An 18-year-old patient was suddenly stricken with high temperature, chills and pains over the extremities. Malaise and weakness followed during the next few days with apparently an enlargement of the cervical glands, painful to palpation.

Figure 15A. Clifford Swanson, Jr., taken after recovery from Hodgkin’s disease following administration of Koch Therapy. A famous Philadelphia Hospital diagnosed his condition and gave him only a few months to live.

He was taken to one of the best hospitals in Philadelphia, Pa., and a biopsy was suggested. The result was a clear diagnosis of lympho-granuloma (Hodgkin’s disease). Deep therapy radiation was advised, as well as surgical resection.

Fortunately for the young man, his father read a scientific lecture one evening, which had been inserted in the Congressional Record by Senator William Langer *, and learned of the results of the Catalytic Medication. Mr. Swanson took his boy to a Detroit Clinic in July 1948, where the first dose of Glyoxylide was given after his physical examination.

*(See the Website’s Table of Contents for a complete copy of this edition of the Congressional Record.)

Following the administration of the Catalytic Agent, the patient’s temperature subsided, and in the next months the cervical gland enlargements decreased to a great extent, with marked relief from pain.

In June 1949, he visited our hospital, First Palma Ceia Hospital, and passed a regular check-up. A chest X-Ray was made at this time. The results are shown here:

There is also some enlargement of the bronchial margin in the right lower pulmonary lobe. The heart structure is normal in position. Costo-phrenic angles are clear.

This patient, C. Swanson, has remained well up to now (August 1949); one year after having been administered the first Glyoxylide dose, and without having suffered any other interference.

(He was observed in December, 1950 and is working everyday.)

Again I would like to remind you of the importance of the chest X-Ray as a diagnostic weapon in lympho-granuloma cases. These above mentioned chest manifestations are undoubtedly manifestations of the virus tubercular infection, and have been observed in my practice for many years in the majority of lympho-granuloma cases.

(c) Chronic Stage of Leukemia

Let us study the chronic stage of Leukemia, which is the most frequent form to appear in general practice. It is in this period that the majority of patients seek the physician.

The chronic stage of leukemia responds in a different manner under the Catalytic Medication, and these changes are dependent on two factors:

(a) Extension of the pathological injury or
(b) Administration of improper medication, depressive and antagonistic to the patient.

Failures in the first group are common when the patient’s condition of toxic manifestations and hematological destructions are so extensive that no recovery is humanly possible.

However, when the patient’s resistance is good and the diagnosis is made in the early stages (chest X-Rays) the recovery under the Catalytic Agent is a frequent occurrence.

Typical of the recovery in this chronic stage are the two following observations:

CASE: Teddy Singletary

An 11-year-old boy, afflicted with lymphatic type leukemia in the past six months, was admitted to our hospital, First Palma Ceia Hospital. The primary examination showed the extremely depressed patient unable to walk by himself. His face showed suffering and freight.

His shortness of breath was very obvious, to the extent that on occasions he was unable to answer any questions. His skin was sallow, and there were bloody, purple spots all over his body. Offensive odors came from his mouth, from which the examination revealed a profuse gingival hemorrhage. Occasionally a temperature of 102 degrees was present in the evenings.

The onset of this manifestation in the mouth and the one of temperature, were acutely in character with manifestations of chills, fever, malaise, severe pain radiated in low extremities, and finally severe anemia with increases leucocytes of the lymphocytic type.

The only therapeutical measure used in this patient had been repeated transfusions (57) in a short period of three months, and with no encouraging results.

Figure 16: A reproduction of the diagnosis made by O. Z. Culler, M.D., of Orangebury, South Carolina, as to the condition of Ted Singletary. Dr. Culler stated that the diagnosis is: “Chronic Leukemia proved by bone marrow biopsy with hemorrhagic diathesis.” Dr. Culler made the diagnosis before Ted Singletary and his family knew of the Koch Treatment.

Figure 17. A clipping from a local newspaper, which is self-explanatory.

Blood count examination at the time of admission was as follows:

Red cells: 2,150,000

Hemoglobin: 40%

Leucocytes: 15,000

The rest of the physical examination showed an enlargement of the spleen, liver structures, and lymphatic glands in the cervical region and groin. Chest examination showed increased tubular respiration in the right pulmonary base, and moist rales over the entire pulmonary field.

Figure 18. Taken of Ted Singletary before receiving the Koch Treatment. The pulmonary field shows cloudiness in both apexes. There are enlarged lymph nodes in both pulmonary hilus, more prominent over the left. Costo-phrenic angles are clear; Mediastinum and heart structure in right position.

After a regular fasting period, 2 c.c.’s of Glyoxylide was given intramuscularly (February 27, 1949), and general care was taken of the oral infection. A week after his admission, he went back home. At the time of his discharge, his temperature was normal, the abdominal distention, particularly in the spleen region, was decreased to a great extent. The enlargement of the cervical glands was also reduced.

The most interesting experience in this recovery mechanism was the rapid absorption of bloody skin patches, which were undergoing a process of absorption and changes in color, from dark blue to light green, yellow, and finally disappeared entirely.

Nine weeks after he had received the one dose of the Catalytic Agent, Glyoxylide, he returned to Tampa for a checkup. At this time, he was able to walk on his own feet, and had gained 12 pounds in weight.

A blood count was as follows: May 5, 1919
Red cells: 3,350,000
Hemoglobin: 52%
Leucocytes: 8,000

A chest X-Ray at the time of his admission into the hospital may be seen in Figure 18.

On May 27, 1949 and exactly in his twelfth week reactional period he complained of epistaxis and some pains in the lower extremities, for which manifestation Vitamin K was administered.

A second checkup was made in our office with the following results:

A blood count was as follows: July 23, 1949
Red cells: 4,000,000
Hemoglobin: 72%
Leucocytes: 6,500

This patient gained 25 pounds from the time of his first admission. He felt good and contemplated returning to his school duties the coming September.

The interesting fact in this recovery mechanism was the fact that no blood transfusions were given and yet his hematological recovery was obtained gradually with increasing value in red cells and hemoglobin, obtainable from healthy regeneration of the bone marrow structures.

This recovery mechanism (hematological repair) did occur immediately. In other words, long before this blood improvement took place, there were manifestations of progress of the functional complaints (weakness, fever, perspiration, appetite, etc.)

In my interpretation, the infection is the first one to be eliminated, which gives hemopoietic structures the ability to take over and re-establish the normal productive blood mechanism, which it is not possible to obtain until the virus is eliminated.

Here is a second recovery observation of chronic lymphatic Leukemia in adult persons.

Figure 19. This is an indoor picture of Ted Singletary and Mrs. J. W. Love.

A member of the staff of The Lutheran Research Society took it in September 1950 during a convention of physicians using Koch Therapy, which was held in Detroit, Michigan. The two recovered Leukemia victims were interviewed at length and appear to be leading perfectly normal lives.

CASE: Mrs. J. W. Love:

A 17-year-old lady came to my office on December 7, 1948, afflicted with Leukemia process well established by her local doctor in Orangeburg, S.C.

Her personal history shows as acute process six months ago, with nausea, chills, fever, and perspiration. These manifestations occurred right after an influenza attack.

After being admitted into my hospital, the rest of the physical examination showed enlarged spleen and liver structures, as well as lymphatic enlargement over cervical region. As in the above case (Teddy) an oral infection was present, with offensive breath and pus pockets over dental structures that required a dentist’s services before she could receive a Treatment.

Dr. Oscar Z. Culler of Orangeburg, S.C. showed the following blood report:
December 13, 1948
Red cells: 3,160,000
Hemoglobin: 57%
Leucocytes: 10,700 Poly: 86%
Lympho: 10%
Mono: 2%
(Myelocytes and pre-myelocytes are present)

As a therapeutical measure she had received from this doctor, two courses of X-Ray over her spleen, long bones and sternum, each course consisting of 600 R at an interval of six weeks.

Following this deep therapy radiation, her condition was no better. Weakness and fever in the evening as well as gingival bleeding spells were present. After her dental problem was solved to a certain extent, she fasted for two days, and on December 13, 1948 one dose of 2 c.c.’s Glyoxylide was given intramuscularly, followed by routine orders.

Due to the fact that she had received intense deep therapy radiation, a second dose was repeated five days from the first one (2 c.c.’s Glyoxylide). She was discharged from the hospital on December 18, 1948.

There are many interesting facts on this patient. One of these facts concerns the moderate increase of the leucocyte myelocyte type. Despite her intense deep therapy radiation where electrical negative charges are reclaimed in the tissues for years to come; her functional manifestations improved very rapidly following the Catalyst administration. Fever was normal at the end of five days; also the chill sensations were normal. The abdomen, the spleen, and the liver were no longer painful to palpation. The oral infection with gingival bleedings had also disappeared.

A blood count made on March 15, 1949 showed the following results:
Red cells: 3,850,000
Hemoglobin: 69%
Leucocytes: 8,500

Up to date, August 5, 1949 she remained well, attending her housekeeping duties, with improvement of 10 pounds in weight and a good appetite.

A third blood count report made on June 16, 1949 showed these results:
Red cells: 4,000,000
Hemoglobin: 72%
Leucocytes: 7,000

In no instance did the above patient receive a single transfusion after the Catalyst Agent was given.

(Mrs. Love was observed in Detroit in September 1950, looking the picture of health.)

You have seen the chest findings and clinical histories of patients with Leukemia in chronic stages of a disease without the interference of improper medication (amintherin, radiated phosphorus, mustard gas, etc.), and how they react following the administration of the Catalytic Agent.

Figure 21:

A reproduction of a blood count report made on Mrs. J. W. Love on May 30, 1550 almost a year after this paper was originally delivered, showing her continued improvement.

CASE: Joe Walley Kay:

A four-year-old boy was admitted to the hospital for lymphatic type of leukemia.

During the past Christmas, feeding in good health, he became ill with severe intercostal neuralgia and high temperature. The pain was so intense that the possibility of rib fracture or injury was thought by his father to be the trouble, but the chest X-Ray was negative.

From the time of onset of his first symptoms, to his admission to my hospital (February 28,1949) his clinical manifestations were similar to previous cases described; malaise, anemia, fever, enlarged lymph nodes, epistaxis, epiderdies, ecchymosis, etc. until the final diagnosis of lymphatic Leukemia was established.

Chest X-Ray was ordered at the time of his admission with the following results:

Figure 22. Picture taken in the fourth month since the onset of the first symptoms. There are enlarged lymph nodes in both pulmonary fields, in the pulmonary hilus, more prominent in the left side. Costo-phrenic angles are clear, Heart, normal in size and position.

The therapeutical measures on this patient were; several transfusions and three doses of radiated phosphorus intravenously given at Philadelphia Children’s Hospital.

After 48 hours of fasting in our hospital, I gave 2 c.c.’s of Glyoxylide intramuscularly, followed by routine orders: ascorbic acid orally and ultra violet radiations.

Blood count was made before receiving his treatment (March 1, 1949) with the following report:
Red cells: 3,900,000
Hemoglobin: 79%
Leucocytes: 5,000 Poly: 38%
Lympho: 61%

Clinical improvement following the first dose of the Catalytic Agent was observed over the enlarged lymph nodes of the cervical region, which decreased in size and tenderness at the end of nine days. The bloody skin spots (ecchymosis) were also very rapidly absorbed. His appetite improved, and the child acted more normal and less irritable.

The outstanding clinical feature in this case was that following the Catalyst dose; no temperature reaction took place, which in my estimation was not a good prognosis. On the other hand, his blood count remained practically the same up to March 14, at which date he was re-admitted to the hospital with a high temperature of 104.

Blood work of March 14, 1949:
Red cells: 3,250,000
Hemoglobin: 59%
Leucocytes: 10,500 Poly: 36%
Lympho: 61%

From March 14 to March 17, 1949 dehydro-Streptomycin was given intramuscularly, a dose of 2 grms. for administration on this fourth day. His temperature returned to normal (95), but his general condition was not good and his blood count was weak.

Blood work: March 21, 1949:
Red cells: 2,850,000
Hemoglobin: 30%
Leucocytes: 9,600 Poly: 40%
Lympho: 57%

He was dismissed from the hospital on March 24, 1949 and went back home. His blood count at the time of dismissal was as follows:

Blood work: March 24,1949:
Red cells: 3,890,000
Hemoglobin: 50%
Leucocytes: 6,800 Poly: 36%
Lympho: 62%

He contracted a severe cold at home and his temperature again increased to 105. Under the care of his family physician, he received some procaine Penicillin. On April 5, 1949 he was re-admitted to the hospital, at my suggestion. On April 6, 1949, a second dose of Glyoxylide was given intramuscularly.

A chest picture was made and showed a consolidation over the left pulmonary lobe, typical of lobar pneumonia.

Despite our efforts, he expired on April 10, 1949. This was a case in which radiated phosphorus was given intramuscularly before he became our patient.

CASE: Miss M. Arthur:

A five-year-old girl was admitted to our hospital afflicted with chronic Leukemia of the lymphatic type. The diagnosis had been established in Lakeland, Florida by a family physician. Until November 1948, she had been a perfectly healthy child. However, at this time, she contracted the measles. After her convalescence, she started complaining of pain in her lower extremities, fever, and chills.

An examination disclosed enlarged lymph nodes over the cervical region and groin. A biopsy was made from one of these glands. The pathological report revealed lymphatic Leukemia.

During the six months of her illness, she had received several transfusions, and intravenous doses of aminotherin without any beneficial results. A chest X-Ray was ordered at the time of admission to our hospital with the following results:

Figure 23. Picture was taken six months from the onset of the symptoms. There are enlarged lymph nodes around both pulmonary hili-costo-phrenic angles are clear. The heart is in normal position.

The rest of the physical examination was similar to the other cases enlarged spleen and liver, multiple bloody spots all over her body. Perhaps the most interesting feature in this patient was the intense severe pain in her extremities, to such an extent that she could not be moved in her bed without severe suffering. The blood count at her admission was as follows:

Blood work: April 23, 1949
Red cells: 2,100,000
Hemoglobin: No figure given
Leucocytes: 9,700 Poly: 19%
Lympho: 81%

After 48 hours of fasting, 2 c.c.’s dose of Catalytic Agent was given intramuscularly. In the following hours, her temperature raised to 102, returning to normal at the end of 72 hours.

Clinical improvement was observed over the enlarged lymph nodes in the cervical region, which became normal in size at the end of five days. She retained food and her appetite improved. The majority of these bloody spots on her skin were absorbed.

The severe pain in her lower extremities subsided, and she was able to move in bed more freely without pain on palpation.

From April 28th to 29th, her condition became worse, with an inability to retain any food, delirium and involuntary control of bowels and bladder followed; she finally expired with heart insufficiency.

 

SUMMARY and CONCLUSIONS

1. Koch’s Catalytic Agent has passed the stage of experimentation, and its curative value in pulmonary tuberculosis infection is a well-established fact in our day.

2. The prophylactic value of the Catalyst Agent as a preventive medicine in pulmonary T.B., is far superior in results to its near competitor-the B.C.G. vaccination.

3. The immunity acquired with the Catalyst Agent injection in potential tubercular families, is not specific in a sense; it is a result of chemistry of immunity.

4. Beneficial and curative results obtained in viral tuberculosis infection in these two forms: Leukemia and Hodgkin’s disease, have also been recognized. The best results are obtained when treatment is given in the early stage of the disease.

5. The prophylactic value of the Catalyst Agent as a preventive medication in Leukemia and Hodgkin’s disease is well understood, from the moment, that the great majority of these cases in children started the clinical manifestations follow the convalescence from exanthema (measles, chicken-pox, etc.) by which the child’s resistance has been broken down.

6. The necessity and importance of an ‘early diagnosis’ in Leukemia is of tremendous value in the recovery mechanism. Physicians should be ‘leukemia conscious’ as well as they are ‘appendicitis conscious’ in an acute abdomen.

7. The chest X-Ray examination will be of a great help in establishing this early diagnosis. These findings are present long before the blood count shows any abnormalities. (See Figure 24).

8. Any patient afflicted with histories of fever, chills, bloody skin spots or enlarged glands, not explained as a result of other diseases, should be considered a potential tubercular virus host, and a chest X-Ray should be made at once.

9. These clinical manifestations and chest findings are more valuable than the results of local biopsy of a tissue, which on many occasions, have failed to establish an early diagnosis in Leukemia, even in the hands of expert pathologists.

10. Transfusions of a whole blood are no longer necessary in Leukemia patients under the Catalyst Agent. However, in a patient with extremely low blood count (below 2,000,000 with a long history of disease) transfusions should be given as a matter of a ‘supporting measure’ in order to gain time with the Catalyst therapeutic action.

11. In the acute stage of a disease and in small children, my experience in regard to the dosage is as follows: 1 or 1.5 c.c.’s is given at admission and this dose is repeated a second time at the end of five days or at eleven days from the first one. In adults and chronic cases, a full 2 c.c. dose is sometimes sufficient. But if the symptoms do not subside properly, or if the patient has been heavily radiated, a second 2 c.c. dose is repeated at five day or eleven day intervals.

 

Chapter 2: The Use of Anticoagulant Therapy and Catalytic Agents in Vascular Thrombosis

OUTLINE

I. Pathology in Thrombosis

   A. Vircho’s Theory

      (1) Blood Disturbances

      (2) Figures 25, 26, 27, and 28

   B. Cohnhein’s Theory

      (1) Vascular Alterations

      (2) No Exhibit

II. Physiopathology – Anticoagulant Therapy in Thrombosis

   A. Medication with Blood Action

   B. Medication with Vascular Action

III. Clinical Observations Supporting Previous Statements

   A. Surgical Thrombosis with Pulmonary Embolism

   B. Berger ‘a Disease

   C. Coronary Thrombosis Status

   D. Rheumatic Carditis Thrombosis

   E. Female Pelvic Thrombosis Post Spontaneous Miscarriage

IV. Summary and Conclusions

FOREWORD

Mr. Chairman, Distinguished Guests, Ladies and Gentlemen:

AGAIN I have the opportunity and the pleasure to speak to you, the members of our medical profession. Although we are small in number, we are large in ideas, and we hope, awake and alert to new scientific developments. Developments which, through interest and knowledge, have gained tremendous momentum in our day, not only from facts established by amazing therapeutical results, but also from facts promoted through a hazing of intense opposition.

Because of this opposition, many of us, and perhaps many of the new members of this philosophy, will face strong criticism. And occasionally, hatred and persecution may come to all of you who are especially well known.

But if we remember the historical trend of scientific development in this world, we will understand these repercussions; and know that all new ideas and discoveries that have a tendency to break down classical, standard methods always invite and promote severe opposition and intense criticism.

Today I am particularly happy to be among the members of the medical profession in the wonderful, western state of Oklahoma. This community should be proud and aware of these regional conventions in which physicians with open minds convene in the American way of life, expressing themselves with freedom of speech and freedom of opportunity!

We should say that in these two days of our convention, more will be done for the care and suffering of humanity, than will be done in the total scholastic convention of the A.M.A., in which the majority of us will just take seats to listen to the same material and the same reports that we know so well. This new theory certainly places us in a precarious situation in regard to those who maintain a different point of view.

I personally consider ex-professor William Koch’s philosophy so amazing and honest in results that I believe all conscientious physicians, in these states and this surrounding territory, should know of his wonderful Therapy. All doctors should be free to criticize and observe Koch’s results up to the time that, by his own experience, he becomes prepared to understand Koch’s Theory, and then he must speak for himself of his results among suffering humanity.

This is my own case. Seven years ago, Dr. William Koch was unknown to me. Perhaps unfortunate ignorance cost the life of many a patient, among them members of my own family. But today I am happy again, and proud of this work which I intend to carry on to the end of my time and my professional practice.

Classification:

This lecture deals with a very interesting and important subject; the anticoagulant medication in our daily practice, and of course the beneficial or injurious results when anticoagulant medications are administered to the patient afflicted with thrombosis of the vascular system.

There are diversified pathological conditions on which anticoagulants are used quite frequently. Among them, I shall mention to you the more important ones in my clinical practice-for instance:

(a)—Post surgical thrombosis with pulmonary embolism.

(b)—Coronary Thrombosis status

(c)—Endo-arteritis Obliterans (Berger’s disease)

(d)—Rheumatic-carditis thrombosis from septic endo­carditis

(e)—Female pelvic thrombosis

In all of these pathological conditions, the vascular system is involved. Naturally, the first question that will arise in your minds will be, “What is a thrombosis?”

A thrombosis is the formation of a plug more or less completely occluding a blood vessel or one of the heart cavities, formed in situ by coagulation of the blood, or a deposition of some of its formed elements. When this clot or a part of it becomes detached and travels to and stops in some other location, forming an obstruction, it is an “embolus.”

But if this definition is a simple matter, the situation will become more and more interesting when you study the intimate problems of “why” and “how” this thrombus is formed, and here is what you call the pathology of thrombosis.

For centuries medical schools have been arguing on this subject. We are still arguing today. However, the question is not to argue, but to save patients’ lives and solve their problems.

And so, it is now necessary for you to come with me on the journey over this so-called Pathology of Thrombosis, in order to secure the benefits and practical clinical conclusions, and to be sure whether or not a particular medication is useful or not in the solution of the problem. In this regard, I speak of the analysis of clinical cases.

In conclusion, I have established the framework of this lecture to include: definition, classification, pathological interpretations, and clinical results of therapeutical values in Thrombosis Pathology.

I. PATHOLOGY IN THROMBOSIS

Our sketch No. 1 divides the study of the pathology of thrombosis in two opposite theories; Vircho’s Theory of blood disturbances, and Cohnhein’s Theory of vascular alterations.

Vircho claimed centuries ago, that the main factor in the thrombosis process was on one side; mechanical factors with tendencies to slow down the circulation of the blood stream, and which slowness could he slight, medium or total as you will see in Figure 25.

Today we know from animal experimentation, that if we perform artificial cutting of the local vascular tissues, the circulation is rapidly stopped in this particular place of vascular injury without ulterior and progressive damage. This is evident in Figure 26.

According to the Vircho Theory, this rapid local repair of the vascular injury takes place by a process of colloidal changes in the blood as a tissue. Among the factors of these colloidal changes, the pro-thrombin level, leucocyte ferments, calcium salts, and hepatic ferments all determine the formation of a local clot.

Today we also know that it is possible to maintain blood un-coagulated between two ligatures or sutures as long as the vascular segment remains undamaged.

But from the moment that the inside of this vascular portion receives an injury by trauma, infection, or allergy irritation, the un-coagulated blood rapidly becomes clotted. This fact leads Cohnhein to believe that the “vascular damage” is the fundamental and primary factor in the formation of the thrombus. First the condition is brought about by an endothelial inflammation provoked by infection, virus, etc., and is then advanced by a chemical disorder, (allergy manifestations).

Not long ago at a St. Louis Convention of Heart Diseases, Professor Hermans, Dr. Decher, and Dr. Schwab, of the Texas University School of Medicine, established the idea, that it was a necessity to make a complete and total revision of Coronary Thrombosis disease as a biochemical disorder.

They spoke, at that time, of the blood level balance between the glycogenic liver function and the phospho-creatinine level. These scientists claim that when the level or production of glycogenic substance in the liver and muscular tissue is not in sufficient quantity, an excess of lactic acid is formed as a result of the breaking down of the glycogenic molecule. This lactic acid remains in situ with a secondary alteration over the colloidal plasmatic stability.

In animal experimentation, in which myocardial damage is produced artificially, they always find a deficiency in creatinine molecules. The same situation occurs in a heart with myocardial thrombosis and hypertension.

Today we know the importance of a biochemical disorder and allergy in determining the endothelial vascular inflammation. Who does not remember the violent vascular manifestations of the Angio-neurotic edemas, which clinical symptoms arise suddenly, are recognized as a definite biochemical disorder, and also as the endarteritis process of pulmonary tuberculosis.

Naturally, following the inflammation, a vascular spasm takes place with transitory or permanent occlusion of the blood vessel, and also affinity exists to precipitate the colloidal elements of the blood plasma.

But if we study the ultimate development of the vascular thrombosis after it is seated inside of the vascular structure, I think we will be able to reach a final conclusion on this argument, which will point out the vascular damage as a main factor in the thrombus formation. If you look at Figure 28, you will see that after the thrombus is formed and located in situ as a “vascular neoplasy,” a local irritation starts taking place right in the base of contact with the vascular wall, and the endothelial cells penetrate into the blood clot which gradually becomes retracted.

Angioblastic formations also invade the inside of the blood clot with a final development of capillary structure, through which the blood circulation practically flows inside the blood clot. In days to follow autolysis and absorption of the thrombus material gradually takes place, carrying back to the blood stream this detritus material. The final formation of the local sear tissue takes place right in the walls of the damaged vascula.

Incidentally, Dr. Koch has described this beautiful and natural recovery of the “vascular neoplasy” in the ‘recovery mechanism’ of malignant tumors undergoing autolysis with the Catalytic Agent.

From the moment that the thrombus undergoes gradual absorption, by a process of cell multiplication of the blood vessel itself, no new clots are formed at that level. Despite the fact that the absorbed material is carried through the blood stream, it is common sense to believe that the vascular alteration is the fundamental factor in the cause of thrombosis.

 

II. PHYSIOPATHOLOGY

Anticoagulant Therapy in Thrombosis

Let us now make a brief study of the therapeutic value and results of medications, particularly anticoagulant medications in the treatment of thrombosis.

With bases in previous dissertations, the therapy in thrombosis is divided into two groups, or more properly, two different opinions among physicians.

As you know there is a group of physicians who are in favor of medications of “blood action,” or more properly, medications with direct effects on the Pro-thrombin time level, decreasing it with temporary effect. Among these medications, which are on the market, are Heparin, Decoumarin, Intercostrin, etc. The other group of physicians is in favor of using medications with direct effects over the vascular problem (vascular inflammation), among which the Catalytic Agents occupy a prominent position.

A. Medication with Blood Action

This medication is given hypodermically in repeated doses, sometimes at intervals of four hours. The necessity for repeated doses, speaks very definitely of the instability of the solution because its elimination takes place so rapidly.

As a result of the coagulation time decreasing effect, on many occasions, complications take place in the form of epistaxis, gastric hemorrhages, gingivitis, subcutaneous skin hemorrhages, etc. In some patients, these complications require urgent attention and treatment, for example, the administration of vitamin K and sometimes transfusions. All of you surely are aware of the danger of a transfusion on a patient with embolic thrombus. It is possible that this transfusion will develop more thrombus, and on many occasions will be a failure.

On the other hand, the anticoagulant therapy does not solve the distant secondary complication (fever, pain, arterial spasm, or infarction) already set by the thrombus formation. Consequently, the patient requires associated medication of Penicillin for the control of the infection, and Papaverine to prevent the spasm of the arterial segment. Neither the first nor the second has had honest results on patients. It seems that very frequently in thrombo-phlebitis of the lower extremities, Penicillin therapy is absolutely unsuccessful, even in large doses. In regard to Papaverine, this has had transitory effect only over the spasm which belongs there, because after all the spasm is the result of the inflammatory process of the vascular endothelial coat.

B. Medication with Vascular Action

As I make an examination of the medication with vascular action, like the catalytic agents, the results present quite a different situation. The first obvious difference is that only “one single dose” is required to render the patient free of many punctures. Bringing your attention to the single dose is a digression from the point of this lecture, but I want you to recall the ”prolonged effect” of the Catalytic Agents as a matter of a chain reaction mechanism.

The principal benefit, however, is over the vascular damage. The process of “Focal infection” is removed from the vascular region without the necessity of anti-spastic medication, from the moment that the spasm is removed as soon as the local infection is wiped out.

On the other hand, the Catalytic Agents also stimulate the process of “thrombus absorption,” and speed up the formation of scar tissue.

Distant complications from the thrombus infarction also received benefits from this medication, with a rapid repair process of the pathological damage. This was the case of my brother, afflicted with pulmonary embolism, followed by inguinal hernia repair.

I finally stress the fact that, if there is an underlying allergy factor, the Catalytic Agent also established a change of this pathological condition by eliminating the irritation on the vascular segment (structural allergy).

 

III. CLINICAL OBSERVATIONS, SUPPORTING PREVIOUS STATEMENTS

A. Surgical Thrombosis with Pulmonary Embolism

CASE: My Brother who is a Catholic Priest, white, 46 years of age was undergoing a routine inguinal hernia repair. On the third day after the operation, he developed a temperature, severe chills, and restlessness.

The surgeon failed to find a local infection in the incision, which had been healing normally. The patient was given a chest examination that showed a negative pulmonary condition, as well as a routine urinalysis for a possible kidney condition.

At the end of this temperature (seven days), the patient referred to an acute, severe pain over the left side of the hemi-thorax, complained of difficulty in breathing, and had developed a cyanotic coloration. A half-grain of morphine was given symptomatically, and the patient was put under an oxygen tent. The examination of the lower extremities showed by palpation, a painful and inflamed vein all along the saphenous trajectory. A chest picture showed, with the findings of left costophrenic obliteration of the left pulmonary lower lobe, an infarction. This patient was given penicillin procaine, 300,000 units every four hours for a period of seven days, Papaverine injections twice a day to relieve the spasm, and Decoumarin as anticoagulants every five hours to keep the coagulation time below 30%. Despite this medication, the patient’s temperature went up to 104°. He had severe dyspnea and difficult respiration and pain over the chest. Penicillin’s fast resistance was considered as possibly due to the fact that the temperature became worse after the seven days.

On the morning of September 4, I received a message from my family of the seriousness of my brother’s condition. After a preliminary interview with his physician, 2 cc. of Glyoxylide solution was given intramuscularly. He was practically unconscious. The next morning the temperature dropped to a hundred, with complete relief of the chest pains and difficult respiration. The cyanosis was removed to a great extent. The phlebitis and painful sensation of the leg disappeared to a great extent, and circulation was reestablished in the toes of the right foot. A week later, after the Glyoxylide medication, my brother was free from temperature, and was able to remain out of the oxygen tent for a period of two to three hours. A second chest plate was ordered seven days from the first one, and the findings revealed the total absorption of the costophrenic obliteration. He was dismissed from the hospital, con­valescent, after receiving a second dose of Glyoxylide on September 14, nine days from the first dose. He has since remained well and has been engaged in church activities as a member of the Jesuit Organization.

B. Berger’s Disease

CASE: This patient is white, 76 years old, male, and is afflicted with gangrene of the left foot. He had been under the doctor’s care for the past two months without too much relief of his complaints—cramps, burning sensation, difficulty in walking, and swelling in his foot. After preliminary consultation with a skin specialist, it was decided to perform an amputation above the knee, due to the gangrene process on three toes, and the bottom of the plantar region.

Blood chemistry determined a negation of diabetes, and the only personal record on the history of this patient was that he was an excessive smoker, and had an allergy manifestation.

This patient was hospitalized and ready for surgery. On the next morning, his inspection showed a pale color, depression, and low resistance, which according to his old age, was indicative of surgical shock. The surgeon was aware of this, and in my preliminary conference with him, he reluctantly denied the possibility of saving the leg of this man unless the operation was performed at once. Nevertheless, on that day the patient was moved back to his home and put under the Koch Treatment, receiving two cc. of Glyoxylide at 8 P. M. that night. Physical examination of his leg showed an offensive odor from his foot, and profuse corrupt material draining from a deep ulceration on his foot and toes. The lower extremity was cyanotic in color and palpation thermostat feelings were absent. His leg was ” cool like ice,” and he was under morphine, other medications, and penicillin to relieve suffering.

The next day, after the Catalytic Agent was injected, he described “throbbing sensations” in the toes, and immediate relief of the pain, to such an extent that the opiates were no longer needed. On the following day, the next improvement was in his circulation and color. The cyanosis was gradually replaced by a pinkish coloration. The temperature of his leg gradually became normal day by day, from the upper part to the ankle region. At the end of five days, the temperature of his foot was practically normal.

The following week, and at the end of nine days, he referred to some pains in the extremity, after which necrotic tissue was thrown out, particularly in the plantar region on one toe.

From a helpless man, who was unable to walk, this patient regained the use of his leg at the end of the second week. Finally, at the end of three months, there was complete recovery from receiving “one single dose of Glyoxylide.” Today, as a member of the Shrine, Elks, and Kiwanis Clubs, he attends these conventions, driving his car, and enjoying practically a normal life.

C. Coronary Thrombosis Status

CASE: A 67-year-old man came into our office suffering from severe epigastric pains radiated to the chest and left arm. These pains had been so persistent that upon occasions he was unable to walk about inside his home. For months he had been under medication, but without much relief. By the time he came to the hospital, his spells had been recurring frequently. During the attacks, he turned pale with shock and there was profuse perspiration, weakness, and restlessness. A physical examination discovered a slight hypertension (167 over 105) and enlarged myocardial organs. I sent this patient to a heart specialist to make an electro-cardiogram recording. From this recording, it was possible to see that the most outstanding feature is the inversion of the T-wave, a typical manifestation of the coronary damage. I discontinued all medication on this patient and, after 48 hours of preliminary diet, administered to him 2 cc. of the Catalytic Agent. During the following months, and particularly within a few weeks after the Glyoxylide injection, this patient was able to move around without fear of pain or distress of the chest. His blood pressure dropped from 167 to 145, and the majority of the pains and cramps in the lower extremity (calf muscles) disappeared entirely.

Three months after this injection, a second EKG was taken. The results showed continuing improvement. At the end of six months a third EKG recording was taken as evidence that he had recovered. This electrocardiogram showed the normal position of the T-wave and disappearance of the myocardial damage. The patient has remained a well man to date, eight years after his first treatment. This recovery was considered impossible by the specialists at the first examination.

D. Rheumatic Carditis Thrombosis

CASE: A 62-year-old white woman who was afflicted with a chronic rheumatic condition, and who suffered a stroke affecting the left leg and arm, was brought to me for treatment. For years she had been afflicted with rheumatic pains in the knees, shoulders, hands and ankles, from which she had not been alleviated by the standard medications.

This chronic affair suddenly became aggravating. She developed a 102° temperature at noon, chills, palpitations, and profuse perspiration. A physical examination showed organic heart murmur, typical of rheumatic carditis. She also frequently complained of pains over the heart region, and shortness of breath when she walked. Her left arm and left leg had been partially paralyzed for the previous two months, despite the lack of history of strokes of cerebral hemorrhages. Since there had been no previous strokes and the blood pressure was normal, I believed that the stroke suffered was secondary to the thrombus embolism dislodged from septic endocarditis. Therefore, I administered intramuscularly, 2 cc. of Benzoquinone (a Catalytic Agent).

The first improvement was the temperature, which became normal at the end of the third week. The pain and distress over the heart region was also improved to a great extent. In the months to follow, the partial stroke of the left arm and leg was improved to such an extent that she was able to walk without the necessity of a cane or assistance. The numb sensation and burning feeling on the hands and fingers disappeared completely, and upon a chest examination the organic murmur was practically impossible to detect.

Since the first dose of the Catalytic Agent, this patient has remained well with no recurrences of thrombosis and has carried on a normal life for the past five years.

E. Female Pelvic Thrombosis Post Spontaneous Miscarriage

CASE: A 23-year-old woman came to me as a patient afflicted with a history of spontaneous miscarriage, after which a pelvic infection was developing, as well as secondary thrombosis of the right saphenous vein. For three months she had been complaining of swelling and painful sensations in the right leg, very sensitive to palpation along the path of the saphenous vein. She had been unable to retain a job because of this con­dition, and was unable to walk, even a short distance. The menstrual cycles had also been irregular, with profuse hemorrhages. Upon occasions menstruation was repeated during the month to such an extent that the patient was so weakened that she was required to stay in bed. The blood count showed mild anemia of 3,000,500 of red cells and 60% hemoglobin. Occasionally, and during the evening, she complained of a slight temperature, with chills and cramps over the right leg. After a thorough examination by many physicians, a “complete hysterectomy” was proposed by a surgeon as the only solution to remove the focal infection and the hemorrhagic complications. This was refused by the patient because she desired to become a mother in the near future. On this condition, 2 cc. of Glyoxylide was given intramuscularly. Following the injection, she acknowledged a marked relief from the extremity pains, and the disappearance of the cyanotic coloration of her toes. The menstrual cycle of the following month was normal in duration and quantity. The chills and fever were abated. A year and one half after the first dose of Glyoxylide, she became pregnant and without any complications, gave birth to a normal child. After regaining her health, this patient has remained well for six years, and has borne two children.

 

IV. SUMMARY AND CONCLUSIONS

From the clinical description of the above patients afflicted with thrombosis of different kinds in the vascular system, we are impressed with the facts of the clinical results and the minimum of therapeutical measures. Coronary thrombosis particularly pays a high percent of damage among patients in this country. The anti-coagulant medications recently employed in coronary patients, do not solve the underlying factor of the disease any more than does an aspirin solve the underlying factors of the headache of hypertension patients. In surgery, thrombosis follows abdominal operations. In particular, hernia and female operations are not solved by anti-coagulant medications. It is a most interesting fact that throughout our studies of the recovery of the Obliterans Endarteritis, surgical resections of nervous plexus or resections of the external arterial cover (described twenty years ago by a French surgeon. Professor Leriche) have not yet proved to be successful measures in the recovery of this process. However, you have seen in the previous pages, the well-established case of Thrombus and Endarteritis that obtained total recovery, even after gangrene process had been established.

I finally considered the amazing results of this therapy in vascular thrombosis, from the standpoint of the preservation of life, particularly new lives, in which the human maternal love represents one outstanding problem.

Female pelvic thrombo-phlebitis has been considered by our school of medicine one of the hopeless incurable diseases, and therefore an obstacle in the way of the maternity opportunity.

The clinical and pathological recovery under the Catalytic Agents is obtained over the infection, the circulatory obstruction, and the fertility of these patients.

I want to express my appreciation for the opportunity to speak to you, and for the kindness and attention of all of you who are gathered here today.

Oklahoma City, Oklahoma

October 5, 1949

 

Chapter 3: The Catalytic Agent as an Antidote to Surgery in Thyroid Toxicosis

Mr. Chairman,

Members of the Local Medical Society,

We are pleased to have the opportunity to bring to your attention and to discuss with you a very interesting subject, frequently in practice and well understood among physicians. I speak of the “thyroid glandular disorders,” and our methods of treatment, which differ from the surgical technique.

Years ago I was training in a specialized unit working on the “surgical treatment” of thyroid disorders. My knowledge was acquired by practical training and attending lectures in Dr. Crile’s Clinic at Cleveland, Ohio. At that time, Dr. Crile’s father was highly recognized among outstanding surgeons in the treatment of thyroid disorders. His skill and technique in goiter resections have been accepted by surgical textbooks and medical journals in this country, and are acknowledged as a classical procedure.

So years ago, I was very proud to begin establishing a surgical approach to the solution of thyroid toxic manifestations. The surgical technique is usually made under local anesthesia: within forty-eight hours after, the stitches were removed, and very insignificant scar tissue appeared. The majority of these patients were able to walk in a short time. We believe it was the first time in the history of surgery that “early ambulation” was established. Today since we are in contact with the use of the Catalytic Agents, our ideas on the treatment and correction of thyroid disorders have changed considerably. This means that for the past four years I have not treated a single patient afflicted with thyroid enlargement with surgical operation!

As a surgeon, I understand that this approach to recovery without surgical operation or surgical mutilation is not advantageous from a remunerative standpoint. However, from the standpoint of results, we save many patients from the necessity of surgery, a scar, and in some occasions from complications that follow. As you know, the thyroid gland is a very essential vascular organ, which is located in the anterior region of the neck, and has profuse circulation and intimate nerve connections.

Years ago in my practice, I found that the most interesting study of the thyroid problems concerns the development of thyroid disorders during the adolescent period, from thirteen to fifteen years of age. Dr. Crile considers this the “school girl” period, during which perhaps the changes of adolescence determine the underlying factors in the development of a goiter in the adult age.

To any clinical man, thyroid disorders seem to be more frequent in the female sex. This is explained by the relationship of functions between the thyroid glands and the ovarian functions. This relationship is so pronounced that in the opinion of some investigators, I quote, “The thyroid gland in the woman represents the womb of the neck.” We know that normally the relationship between the thyroid and the ovaries is often noticeable during pregnancy, as well as during the menstrual cycle, at which times the thyroid gland is frequently en­larged.

In the male sex, this glandular relationship is different from the female. The relationship, in fact, is much less pronounced in the male. Very seldom in my practice have I seen thyroid tumors in males. It seems that in the male the thyroid secretion has more tendency to attribute to physical development rather than to influence the sexual glands. Consequently, the thyroid gland in females is a weak point of the glandular system, particularly the ovarian and pituitary systems.

The importance of focal infection was described years ago by Professors Gray and Womack of the Department of Surgery at the University of Washington. From the autopsies of forty-one patients whose deaths were caused by diseases like pneumonia, heart conditions, and pleurisy; the post-mortem examinations of the thyroid glands showed that 26 percent were considered a normal tissue while the remaining 74 percent were affected with degeneration. The same doctors, experimenting on guinea pigs that had been injected with toxins of different kinds and with animals in which they provoked artificial intestinal obstructions (lock bowel), discovered that the thyroid examinations showed systematic glandular alterations. In our opinion and estimation, the focal infection is a secondary factor in the production of thyroid toxicosis.

The deficiency of iodine, which is lacking in different degrees in relationship to the enlargement of the glands, has been also considered an etiological factor in thyroid toxicosis. In my interpretation, the iodine production of the thyroid gland is a physiological function, which could be increased or decreased, in excess of defect, depending on the relationship with the pituitary and sexual glands.

I would like to mention a recent interpretation of the etiological factor in thyroid disease: the bacteriological problem.

Careful pathological examination of thyroid specimens from patients afflicted with goiter, has shown the German bacteriologist, Prof. Von Bremmer, the existence of spore strains of different shapes and arrangements which, he believes, is the living organism producing thyroid growth.

These spora have been designated with the name: siphospora polymorpha. According to Prof. Von Bremmer’s interpretation then, the “spora in cyclos 8,” is the organism producing malignant tumor (cancer’). For many years, Dr. Koch has called attention to the theory that thyroid tumors are pre-cancer growth structures. (He has done this in his book “Chemistry of Natural Immunity.”) Long-standing cases of thyroid growth usually ultimately develop or transform into the malignant stage.

The importance of the bacteriological factor (siphospora polymorpha) in the production of thyroid disorders cannot be overemphasized. It shows once more that the Koch Therapy can deal with this condition and is the logical treatment in the attempt to correct it by eliminating the toxins of the producing organism through the intense oxidation created by the administration of the carbon Catalysts.

Classification:

To a practical physician thyroid toxicosis will occur in two forms: thyroid toxicosis with enlarging glands, which is the so-called tumor or goiter, and thyroid toxicosis without the enlargement of glands. In both cases, the patients referred to the physician had typical manifestations: loss of weight, nervousness palpitations, and menstrual disorders. On occasions gastro intestinal manifestations were also present in the form of diarrhea and abdominal complaints. These patients develop a very strained, peculiar facial expression.

When the tumor is present, the diagnosis is not difficult to he established. The case of diagnosis is quite different, however, in the case where the tumor is not present and yet the gland is functioning in excess. There is thyroid toxicosis without tumor manifestations, which occurs frequently during adolescence. To a confident, capable surgeon the first group of patients is a sure target for his work. However, for the second group of patients without tumor, the surgical approach is usually considered more carefully, even perhaps as an improper remedial measure.

In my estimation we have in our hands today a wonderful “antidote” for the “hungry surgeons” who would perform surgical mutilations of thyroid toxicosis patients. This “antidote” is the Catalytic Agent.

Female disorders are prominent among the symptoms of thyroid toxicosis. Patients refer to irregularity in the menstrual period and occasionally to a profuse menstrual flow that requires rest in bed. The second manifestations of importance are palpitations and irregular heart beats with a change in blood pressure. On many occasions, these circulatory disturbances are mistaken for heart disease.

Among the other manifestations of thyroid toxicosis are shortness of breath, difficulty in swallowing, and sensations of strangulation or spasms in the throat or chest region. Nervous manifestations are frequently observed in the forms of insomnia, melancholia and other manifestations, which occasionally place these patients under the treatment of a nerve specialist.

Functional Tests:

Among the functional tests in thyroid toxicosis, the first one was described in 1915 when the Mayo Clinic established the first Basal Metabolism test unit in this country. The Basal Metabolism tests, in the opinion of Dr. Crile of the Cleveland Clinic, are tests of importance in the establishment of the diagnosis, but are not to be considered as absolute proof of the disease. Dr. Plummer and Dr. Rankin are of similar opinions. In other words, it is a frequent occurrence that a patient afflicted with functional manifestations of thyroid toxicosis, reacts normally to the metabolism test. Failures of the test are explained by the fact that there is no reason to believe that the disease is confined to one particular organ, and because there is a relationship among the glands affected by pathological disorders.

Treatment:

For many years the treatment of thyroid toxicosis has been considered a surgical approach, particularly in those cases where the glands are afflicted with a tumor. Symptomatic treatment has been employed, however; for which the iodine solution, Lugol’s solution, and Buehan’s solution were introduced by Dr. Plummer. Dr. Mason and Dr. Star of the Royal Victoria Hospital of Montreal corroborated the iodine solution in thyroid toxicosis.

Today we know that the Lugol solution, which has been discriminated against, does not solve thyroid toxicosis problems, but only gives a temporary relief over the clinical manifestations. This solution is used only as a preliminary medication to the surgical technique. Bromides, Phenobarbital, and similar symptomatic medications are also administered to give temporary relief from clinical symptoms.

Hormone therapy (anterior pituitary and ovarian substance) has been tried for the remedy of thyroid disorders, but does not seem to improve or control the clinical symptoms except in a temporary way. Insulin has also been used experimentally in thyroid toxicosis, particularly on patients who have lost large quantities of weight.

Within the last two years, the medical Staff of Lahey Clinic in Boston has extensively used Thiourocil and its two derivatives, Propyl-thiourocil and Methyl-Thiourocil in the treatment of thyroid disorders. At the Lahey Clinic around thirteen hundred patients afflicted with thyroid disorders were treated with the Thiourocil medications. In a review, Dr. E. C. Bartels, of the Department of Internal Medicine of the Lahey Clinic, estimated that this medication is the “choice” of the treatments of toxic goiters. Furthermore, failures, if they take place, are the result of either improper dosage of the drug or an improper diagnosis of the case.

The daily doses of Thiourocil used at the Lahey Clinic is between six hundred mgm. for Propyl-Thiourocil, and two hundred to three hundred mgm. for the Methyl-Thiourocil.

Today we know that this medication’s failure to overcome certain definite complications is due to the toxicity of the drug. This is true particularly in blood disturbances like Leukopenia and Agranulocytosis. In case of emergency complications, blood transfusions are required to overcome the complications caused by the drug toxicity. Minor side reactions from these drugs include nausea, sensations of numbness, severe pains in the joints, and arthritis.

Dr. Crile believes that the beneficial result with the drug necessitates doses as high as four hundred mgm. daily. There were prompt remissions of symptoms and elevation of the Basal Metabolism test rate when the doses were reduced to two hundred mgms. daily.

In my estimation, the practice of medical treatment of goiter with this preparation is a precarious one because of the dangers of complications developing, of the necessity of prolonging the treatment, and above all, danger from the toxicity of the drugs. The inability of “medical treatment” in thyroid toxicosis was a reason for opening the doors to the “surgical approach” in the same way; an attempt at remedying pulmonary tuberculosis has been approached through surgical resection. Surgical interventions in thyroid toxicosis have been shifted from the ligature of the thyroid arteries up to the subtotal resection of the glands.

Unfortunately, on many occasions’ surgical resections of thyroid glands, as a treatment for thyroid toxicosis, is also a total failure, no matter how skilled the surgeon may be. Some patients, upon whom we have operated, continue to show different clinical manifestations plus complications, arising from the surgical operation. Occasionally the development of hypo­thyroid symptoms takes place with skin dryness, lack of respiration, drowsiness, coolness, and fatigue and swelling of extremities and eyes. These manifestations are very closely related to a myxedema so-called hypothyroid deficiency. At times I have seen severe complications occur right on the operating table, during the process of thyroid resection. The patient developed cyanotic coloration, irregular respiration, and coma persistent for seventy-two hours after the thyroid resection. This patient was revived by a single administration of two c.c.’s of Glyoxylide solution, which re-established the internal oxidation mechanism. Therefore, in my experience, the use of the Catalytic Agent in thyroid toxicosis should be divided into two groups: (1) Patients on which surgical operation has been performed, and (2) Patients on which the surgical approach has not been established.

In the first group, you will find serious complications that occur during the operation and complications that develop months after the surgical operation. This is when the patient still shows all the clinical manifestations of the thyroid toxicosis despite surgical skill. In these two particular cases, the Catalytic Agents have been proven to us to be wonderful in results. I speak in reference to a patient who had been condemned never to recover.

In regard to the second group, patients without surgical operation, afflicted with enlarged tumor of the thyroid gland, has proved in the last four years that it is no longer necessary to use symptomatic medications such as Phenobarbital, and Lugol’s solution. Neither is it necessary any longer to use the surgical approach. Following the administration of one dose of the Catalytic Agent, in less than three months after the injection, the patients show improvement in the functional symptoms, nervousness and choking sensations. They increase in weight, relax, and the majority of circulatory symptoms fade away.

In my experience, the absorption and disappearance of the tumor is the last evidence of the disease to take place. Slowly and gradually during the reactionary cycles of the medication, temporary enlargement of the glands take place. This is due to the increased vascular circulation. However, in the months to follow, the excess of the tissue is gradually absorbed so that at the end of the eight or nine months of the single treatment, there is a total disappearance of the tumor formation. This recovery is permanent.

I would like to illustrate one of our observations with Figures 29 and 30Mrs. Bertha Smith was afflicted with a tremendous tumor (18 in. circumference). During the last year, the tumor became so enlarged that she was unable to sleep in bed. Her neck receded to thirteen inches in circumference after two doses of the Catalytic Agent. Today, this represents practically the convalescent stage.

Figure 29. Mrs. Bertha Smith. A frontal view of the enlarged and inoperable goiter, taken on February 28, 1947, before Glyoxylide was administered.

Figure 30. A lateral view of Mrs. B. Smith taken the same day, February 28, 1947, before Glyoxylide was administered.

Conclusions:

1. Under the Catalytic Agent, it is no longer necessary to use the surgical approach as a treatment of thyroid enlargements. The tumor is totally and gradually absorbed. Patients recover well without the necessity of surgical amputation.

2. The Catalytic Agents have been useful in the treatment of thyroid toxicosis after surgery has been unsuccessful. The Catalytic Agent not only controls the toxic manifestations, but also re-establishes the damage produced or developed by the surgical operation. Among these manifestations of hypothyroid functions, after surgery is the Myxedema on which the administrations of thyroid extract has proved unsuccessful even when used in large quantities.

3. The Catalytic Agents have also a prophylactic value in thyroid toxicosis without tumor manifestations, far more superior to any other treatment. This is particularly true of young people during the adolescent period.

4. The administration of Glyoxylide re-establishes the physiological function of the thyroid gland in size and normal activity, and prevents the development of the tumor formation by elimination of causative producing organism siphospora polymorpha.

5. Over the secondary complications: menstrual disorders, heart disorders and intestinal complaints, this medication has also shown beneficial results. 

I would finally like to stress the simplicity and non-toxic effect obtained with the carbon Catalytic Agents. The people taking these treatments are patients made free of repeated frequent doses, as well as on the safe side of permanent recovery and unnecessary surgical intervention. On the other hand, the recovery process under this medication is far superior to any other medical treatment. This is due to the re-establishment of normal physiological balance between endocrine systems pituitary, adrenals and ovaries not obtainable with the other treatments.

It has been a pleasure to be with you here today. Thank you for your invitation and your kind attention. I Sincerely hope that my comments and illustrations on the Catalytic Agent as an Antidote to Surgery have been enlightening and beneficial to you.

Nashville, Tennessee

November 22, 1949

Chapter 4: The Catalytic Agent in Cases of Acute and Chronic Leukemia

Mr. Chairman, Physicians and Surgeons;

WE ARE HERE in Chicago to discuss again the difficult problems of Leukemia, a subject on which a preliminary report was given at our first National Convention in Detroit in June 1949. It is not my intention today, to entertain. I hardly expect to make you laugh, because I do not claim to be or to have the humor of the late Will Rogers. I do not hope to make you cry, because I do not have the dramatic ability of Barrymore. However, I do sincerely hope that I can cause you to think and act for the solution of Leukemia a disease, which has a steadily increasing mortality rate in the United States.

Perhaps this rise in the mortality rate of Leukemia is due to the fact that we are becoming more conscious of the diagnosis of these cases. I wish here and now to explain to you that I alone take full responsibility for whatever I may say to you today. No one prompted me to make any statement: no one has read or asked to read my manuscript. If you have any objection to my remarks, place the blame strictly on me. As Dr. Ira Allison said in his address before the American Farm Research Association, “The prevention of most diseases has more possibilities than the treatment.”

Recently we have admitted a four-year-old child, Cheryl Greene, from Hagerstown, Maryland as a patient in our Tampa, Florida hospital. This child has been afflicted with a chronic Leukemia of Lymphatic type for the past nine months. Cheryl was another case similar to many brought to our institution as a last resort. But, in her particular case, her name is very outstanding in our records due to the significant developments that occurred in her clinical case during the observation period in our hospital. She followed the same instructions as the other Leukemia patients under the Oxidation Catalytic Treatment, receiving Glyoxylide and a preparation of Cobalt Mineral solution. Her parents, particularly her father, Mr. Carl Greene, who is associated with the Central Laboratories Inc., manufacturer of Concentrated Minerals in Hagerstown, Maryland brought to my attention the remarkable results obtained with this Cobalt mineral solution in the field of nutritional problems.

Blood Formulas, Reaction Cycles and the Oxidation Catalyst:

Similar reports have been made by the association of the Southern Commissioners of Agriculture with the use of mineral solutions in the treatment of various infectious diseases. Our Leukemia cases today, receive among the supporting measures, a daily dose of the Cobalt solution with gratifying results in the blood formula. These results are obtained in the weeks following the administration of the Glyoxylide solution. In our previous experience the blood count series made in Leukemia patients after the administration of the Glyoxylide solution reveals that in every instance a temporary decrease in the red formula and hemoglobin content occurs. This reaction is so pronounced that on occasions a small supporting transfusion, not over one hundred c.c. of blood is required by these patients. One typical example of this type of case, is our observation thirteen in which the patient reported a red blood count of 3,250,000 red cells and 60 percent hemoglobin at the time of his admission. After forty-eight hours he received one and one half cc. of the Oxidation Catalyst. His blood count then dropped to three million red cells and fifty-five percent hemoglobin. This temporary decrease, produced by the Glyoxylide solution in the blood formula in Leukemia patients, is just a part of the recovery process. We remember that the peripheral blood is produced in the bone marrow structure in which location the virus infection is first located. The statement that the first symptom to come is the last one to go, describes this process.

In our experience, the majority of chronic Leukemia patients under the Oxidation Catalyst do not show marked improvement in the red formula of hemoglobin before the sixth or ninth week after the administration of the injection.

However, in acute cases of Leukemia in which the diagnosis was made in the early stages, the blood regeneration takes place more rapidly due to the fact that the bone marrow structure has not been affected to any great extent by the infection. The physio-pathological interpretation in the blood decreasing reaction is well understood if we remember that in the recovery mechanism of chronic diseases, the pathological trend has to be changed to the acute stage before it is wiped out. As a rule it is observed within the first twenty-four or forty-eight hours after the Oxidation Catalyst has been injected, that in all the chronic Leukemia cases there is an increase in the temperature to 103° or 104° during the following days. Then the temperature subsides again gradually during the next three to five days. It is perhaps on this account that the blood formula receives a temporary setback. However, other clinical manifestations of recent appearance such as glandular enlargements, profuse perspiration, distended abdomen, and splenomagalia improve very rapidly during the initial reactional periods above described. This was the case in our observation eighteen of a fourteen-year-old boy whose spleen enlargement reached the pelvic region at the time of his admission. In the following five days after receiving the Glyoxylide, the spleen enlargement decreased to such an extent that it was palpable above the umbilical line. It has been our experience with patients afflicted with chronic Leukemia that through the administration of highly diluted Cobalt Mineral solutions (taken internally, diluted with water, fruit juice, or milk at the rate of ten drops three times a day) we find a remarkable improvement in the red blood count and hemoglobin. These beneficial results re-establish temporarily the depressive action that initially takes place after the administration of Glyoxylide.

Another interesting point to be discussed on this Leukemia mechanism concerns the hemorrhage problem. These hemorrhages take place in the forms of profuse nose bleeding, ear bleeding, and kidney bleeding; and on occasion rectal and colonic hemorrhages.

The nose bleedings are the most frequent and are sometimes so severe that they require nasal packing. They occur in the days following the administration of the Oxidation Catalyst and are, as a matter of fact, present in the patient at the beginning of the disease. I formerly used a local topical application of Thromboplastine supplemented by 10 c.c.’s of Thromboplastine hypodermically every twelve hours. But, since I have used the Cobalt Mineral solution, I find that a topical application with the solution in full strength is more effective than anticoagulants. The hemostatic effects of the Cobalt or mineral solution have been proved (in-vitro) by the work of Dr. Francis M. Pottenger, Jr. of Monrovia, California.

I use this mineral solution also as local topical application in the buccal cavity around the gum formation, painting the gums with an application twice a day or packing in the nose cavity with a gauze moistened in the solution.

During our observations of intestinal hemorrhages of the lower bowel, we used a solution of two teaspoons of Cobalt in one pint of warm water given as a retention enema at a very low pressure. This solution is similar to the one used for buccal cavity hemorrhages.

Urethral and Cystitis have also been used with Leukemia patients. We have discovered that bladder irrigations with these and similar solutions have responded very satisfactorily. All of the above Leukemia disease cases from the hemorrhage to the breaking down of the blood formula are expressions of chronic affairs, or more properly, manifestations of the disease in the far advanced stages. Very unfortunately for us, in our present day, Orthodox theories attack the problem of the disease with the idea that there is only one acute visible symptom in existence. In other words, the disease must be shown by an excess of symptoms and complaints, otherwise it is not in existence.

Malnutrition, Leukemia, Proteins and the Koch Diet:

If we see our Leukemia patients in the first two months of the onset of the first manifestations, I am sure that the recovery process under Oxidation Catalysts will be as high as eighty to eighty-five percent. There are other factors of interest in the management of Leukemia patients, as well as in the development of the disease. There is the nutritional deficiency and the infection-producing organism. Concerning the nutritional problem, I would like to say, that the majority of our patients, as shown in our hospital records, are small children with a history of exanthemas (measles, chicken-pox, etc.) family histories of nutritional deficiency among the parents, and the birth of children to parents reaching their middle age. I am sure that more than one third of these Leukemia patients are suffering from malnutrition at the beginning of the disease. I mean by malnutrition, that these people or children were not receiving the proper food for good health or food of proper quality. These conditions of malnutrition are very insidious as Dr. Ira Allison said in his address before the American Farm Association, “It does not hit you on the head like a blow from a sledge hammer, it comes on you gradually. It reduces the body’s resistance to disease.”

Professor William A. Albrecht of the Agricultural College of Missouri and his vision of broad implication in nutritional problems said, I quote, “Our bodies are built from the ground up, and the minerals from the soil provide needed nourishment for our bones, blood, muscles and nerves.” Working in ‘the same direction, Dr. Levis of the School of Applied Science at Cleveland, Ohio and Professor Erf of the Ohio State University have both found in the analysis of the blood and brain of fifty Bangs reactions, that two small elements, Manganese and Copper were seriously depleted in the diseased animals. The same group of animals showed no traces of Cobalt remaining.

The investigators concluded that Manganese acts in the animal or human body somewhat as do the secretions of the endocrine glands. It forms antibodies, which afford protection against certain disease. As Dr. Allison says, “Civilization and good health prosper on fertile soils, civilization and good health deteriorate on infertile soils.” Fifty to one hundred years ago this was no problem in America because our soil had these minerals in abundance, and of course kept the plants growing for those who feed on the plants. However, repeated and long continued trucking has long ago wiped out these reserves except in the newer lands of the West.

Now going back to our Leukemia problems, you can see also why the Koch Diet is a basic nutritional factor in the disease recovery process. Let us mention some of these subjects, milk, for instance. The Federal Pure Food Laws define milk as follows: Milk is the whole, fresh, clean lacteal secretion obtained from the complete milking of one or more healthy cows properly fed and kept. How much of our milk today meets this requirement? How can milk pass the pure food law requirements when between ten and twenty percent of our cattle are affected with Bang’s disease? Do you know of any milk processing plant that requires milk to be tested for Brucellosis? They have used every means to make popular the word pasteurized. Pasteurization is supposed to kill all infected bacterial material. Yet, we are having outbreaks in cities that require every bottle to be pasteurized before being sold. Pasteurization will often kill the Brucellosis bacteria, but not always. Remember when you consume milk you are consuming cooked bug juice. It is most positively a fact that pasteurization kills many desirable bacteria. Pasteurization also destroys many of the enzymes.

Let us examine another interesting fact in the Koch Diet; this observation concerns the requirements for meats. According to the pure food requirements, meat flesh is any cleaned, dressed, and properly prepared edible part of animals in good health at the time of their slaughter. ‘We wonder if a Bang’s cow is a healthy or a diseased animal? Now just what is happening today? What is done with the animal that has an abortion? Is this animal sold to the packinghouse? These animals that have died from infections, are cut up and sold for human consumption. These animals are purchased at a reduced price, yet often sold to you as grade A Government inspected meat. The common excuse given for killing cattle with Bang’s disease, is that the disease is contained in the uterus and udder. You are also told that there is no danger possible to the housewife handling the meat. Dr. Harvey discovered the circulation of blood many years ago, and found that all blood passes through one organ, the heart. Remember we can and do grow cultured cultures from the blond of infected animals; also cultures can grow from meat, and from the secretion of the lymphatic glands.

I hope I do not spoil your appetite for steak this evening. The above statement concerning the milk and meat problems in our diet can be corrected with the proper mineral supplement fed to the animals. But it is clearly understood that the minerals intended to correct disease and malnutrition, are not supplied only with the feeding doses given in the forms of mineral to our livestock. In other words, the animals should get all of the necessary nutrition that they need from their pasture and their rations. If they do not obtain this mineral in the pasture, the meats and milk will not contain such minerals. This explains why we in the United States use two million pounds of vitamins per year. I will let you figure the cost. During the same year we purchase seven million pounds of aspirin to relieve the pain in our aching joints and heads. Any physician, if he is honest, who prescribes minerals or vitamins for his patients, will tell them that they can get what they should have from their diet. Until recently no effort whatsoever has been made in any medical college to teach the science of nutrition. Many are not doing so at the present time. It has been mentioned to me that there are not enough physicians prepared in nutrition to supply all of the medical colleges with competent men. At least one fourth of the medical students’ expenses in a college should be devoted to the study of preventative medicine. By preventative medicine, I mean the understanding of proper nutrition and sanitation. Then we will not need more hospitals and insane institutions, but we will need a better understanding of nutrition.

Leukemia and Infection:

It has been interesting to us to note that the majority of large medical institutions with facilities for wide research as to the cause of diseases have not been interested in the study of Leukemia from the standpoint of being produced by an infective organism. I am of the opinion that the day is coming, when these infective organisms will be visualized through the examination of a fresh specimen of blood under a powerful microscope of electronic type. When this comes to pass a blood specimen taken from the patient will be all that is necessary to obtain a specific auto-vaccine. The blood specimen should be placed under proper incubation at high temperature (240°) in order to destroy all secondary infective organisms. Any bacteriological technician knows that the only organisms to survive the incubation process will be a virus or spore form of bacteria.

The vaccine obtainable from this process will be autogenous with a dilution in increasing doses, and should be used with the Glyoxylide medication with no accompanying medication. The cultivation of the Leukemia sporo-virus should be obtained preferably from the chicken embryos. A dose should be given the animal under experimentation followed by standard autopsy examination of the heart structure, spleen, liver and lymphatic organs in order to corroborate the similarity of pathological lesion between the human host and the animal experimentation. It is our opinion that such Leukemia auto-vaccine, given to the Leukemia patients in increasing doses will destroy the majority of acute clinical manifestations (chills, fever, malaise, etc.) as well as the cardio-vascular manifestations. Recently, from close observations of the acute Leukemia patients we have noted the frequency of cardiac complications that have never been described in any medical textbook.

The special characteristic of the cardiac failure in the Leukemia patients in the rapid increasing heart beat, paroxysmal tachycardia) and the presence of a heart murmur (mitral systolic murmur). Clinically, the patient is pale, with a typical bluish discoloration of the lips, fingernails, with occasional pains occurring over the precordial region. The cardiac complication is acute in character, is due to a direct injury over the endocardium membranes caused by the infective organism’ (Leukemia, a virus-spore). From this source (septic endocarditis of anaphylactic type) hemolysin material will pass into the blood stream and into circulation causing a large number of red corpuscles to be destroyed.

In Closing: I will quote a statement made by Dr. Hale of Dow Chemical Company. “If a change is not made in our present methods of handling the soil so that we may get better food, only God can preserve this United States from diseases such as Leukemia, Polio, and similar virus infections.”

It is my pleasure to show for the first time in Chicago, the sound and color picture of the importance of the mineral supply in the growth and conservation of health among the dairy farms in this country. This film will also attempt to show the results and how the mineral supply applies to the human race. We must have good food if we are to enjoy good health.

Summary and Conclusions:

1—Nutritional deficiency seems to be a prevalent factor in the majority of our records of the Leukemia disease, as well as the infective producing organism.

2—High dilute Oxidation Catalysts (Glyoxylide) has been proved of great beneficial results on Leukemia patients, provided it is taken in the early stage of the disease. In the chronic stage beneficial results are obtained but sometimes a booster medication, preferably Benzoquinone should be repeated at the end of the thirteenth week or perhaps the eighteenth week.

3—My percentage of recovery, in early cases, is as high as 80 percent to 85 percent when patients reach us within a 90-day period after the onset of symptoms. In chronic delayed cases, these recoveries decrease to 40 percent, due to the far advanced stage of the disease, as well as the administration of depressive medications, especially, aminopterim (folic acid derivative) radiated phosphorus and nitrogen mustard.

4—The necessity of “early diagnosis” in Leukemia is of tremendous importance in the recovery process, and makes true the statement: the prevention of disease has more possibilities than the treatment of disease.

5—Physicians should be “Leukemia conscious” as well as Appendicitis conscious in Acute Abdomen.

6—The administration of Cobalt solution in a high dilute dose on our Leukemia patients has proved beneficial for improvement of the blood count as well as in checking bleeding complications. Supporting medication such as Benzoquinone and Chloromycetin has also been satisfactory.

7—A better understanding of nutritional problems as well as “prophylactic” administration of the Oxidation Catalyst in a ”potential host” of the Leukemia disease may help prevent the ultimate development of this family tragedy that occurs today so frequently in American homes.

Thank you for inviting me as your guest today. I appreciate the opportunity to speak to you on this subject which is so much a part of my life and my work, and which is so important to the health and welfare of our country. I hope that someday through the efforts of those in the medical profession, the dreaded disease, Leukemia, will finally become a curable and a less frequent disease.

Chicago, Illinois

January 6, 1950

Chapter 5: The Catalytic Agent in Allergy, Rheumatism and Heart Pathology

OUTLINE

I. Importance of Rheumatic Disease

II. Etiology and Allergy Factors

III. Gross Pathology and Physiopathology in Rheumatic Disease

IV. Clinical Symptoms in Rheumatic Disease

   a) Atypical forms of Rheumatic Disease

      (1) Observation I: an 8-year-old girl

      (2) Observation 2: a 45-year-old lady

   b) Acute forms of Rheumatic Disease

      (1) Strep throat infection

      (2) Scarlet fever

      (3) Rheumatic-Carditis

      (4) Acute inflammatory poly-arthritis

   c) Chronic Forms of Rheumatic Disease

V. Treatment of Rheumatic Disease

VI. Summary and Conclusions

 

FOREWORD

Mr. Chairman, Members of the Medical Profession, Ladies and Gentlemen;

WE ARE HERE today because of a man of conviction—a man of courage and determination, who stood years ago and told the medical bosses of that time about the birth of a new philosophy in the Healing Art of Medical Science which was successful when applied to the correction of disease. This scientific discovery was not made by magic, but was obtained by investigations and patients’ observations through a number of years at a time when other medications were used and were recognized (regardless of the unsuccessful results) in preference to this recent discovery. Today, amid the discoveries of penicillin and wonder antibiotic drugs at almost every stroke of the clock, we realize that not all of them have proved satisfactory on every occasion. Many of these wonder drugs are nuisances and failures. However, we have found that the aforesaid philosophy is able not only to withstand the criticisms and attacks during a quarter of a century but also to remain un-touched and unchallenged even to this day.

The statement causing such controversy for the past, present and future generations of medical science is as follows:

“A carbon compound in double bond arrangements with oxygen has had power to act as an Oxidation Catalyst in the step-up process of breaking down the carbohydrated metabolism of sugar molecules which function to maintain or reestablish the ‘natural immunity process’ of the human body against disease and deterioration.”

Because of the above amazing statement, which has proved to be a reality in thousands of clinical cases of his own and of many other physicians both in this country and abroad, the aforementioned man has been kicked about.

Let us recall the beautiful words of an outstanding poet:

“Truth forever on the scaffold
Wrong forever on the throne;
Yet, that scaffold sways the future
And behind the dim unknown
Standeth God within the shadow
Keeping watch above His own.”

Today, that man of conviction, courage, and determination is with us. All of you know him: Dr. William Frederick Koch. To you, Dr. Koch, in the name of suffering humanity, and in the name of thousands and thousands of patients in the U. S. and surrounding territories to whom you have brought happiness by your methods, I respectfully dedicate these lectures in Rheumatic Disease.

 

I. IMPORTANCE OF RHEUMATIC DISEASE

Dr. Wheatley of the American Academy of Pediatrics recently emphasized the importance and seriousness of Rheumatic Disease problems. He estimated that in the present population of the U. S. there are three cases of Rheumatic Disease for every 1,000 persons under the age of 20, 6.5 for every 1,000 persons between the age of 20 and 40, and 8 cases for every 1,000 persons between the age of the 40 and 50 bracket, making an approximate total of 600,000 cases of Rheumatic Heart Disease under 50 years of age.

In the years from 1942 to 1946, Rheumatic Fever cases had a death rate of 6.4 per 1,000 for the age between 5 and 9; 9.0 for the ages 10 to 14; 13.1 for the ages 15 to 19 and 15.6 for the ages 20 to 24.

The only rates of death higher than this death age group were 6.6 for cancer in 5 to 9 and 27.8 for T.B. in the ages between 20 and 24.

For supplementary data, and to prove that Rheumatic Fever deserves our earnest attention, I would like to recall the yearly rate of mortality reported by the N. Y. State Health Department on Rheumatic Heart, which is between 30,000 to 60,000 persons per year. In addition, every year an outbreak of 260,000 new cases of Rheumatic Fever is reported with or without heart pathology.

 

II. ETIOLOGY AND ALLERGY FACTORS

Let us consider Etiology in Rheumatic Fever. The majority of the textbooks in our early days of college defined the Rheumatic Disease as an acute infection with multiple locations over the cardio-vascular system, primarily, and inflammatory process over the large joints and membranes of serous cavities. In an acute infection, the most frequent germ isolated by different investigators seems to be the hemolytic streptococcus. In this particular field, worthy of mention are the interesting scientific works of an English investigator, Professor R. C. Lancefield, who first called our attention to the relationship of cell structure to biological activities of hemolytic streptococcus.

As in Pneumonia process, which in the past years were classified or typed in 33 different groups of germs, it seems that hemolytic streptococcus is also classified in different groups according to the agglutination factor, on which process the carbohydrate content of the capsules surrounding the germs play an important function in the determination of the different types of streptococcus germs.

From the foregoing observations, Prof. Lancefield described seven independent groups of hemolytic streptococcus, which he labeled with Type A.B.C.D.E.F.G. Probably Type A. is mainly responsible in the process of Rheumatic Disease. Quinn made similar observations in 1948. In 1949, Harris recorded that the titer of Antibody to a streptococcus hyaluranidase (so called a spreading factor) was significantly higher in the patient with Rheumatic Fever than in the patient convalescing from streptococcus infection.

Harris made an additional statement that the titer of Anti-Hyaluranidase in the serum correlated well with the activity of the Rheumatic Fever process. To summarize we may say that the opinion of Lancefield’s research and our knowledge of today indicates that the streptococcus capsule contains a carbohydrate factor or enzyme so-called hyaluranidase which in contact with the host developing in the serum or blood stream antibodies substance gives a reaction which can be determined by a serological precipitation.

Patients with positive agglutination in the above substance are afflicted with Rheumatic Disease, and patients with a type of streptococcus not belonging to the Group A., are not afflicted with Rheumatic Disease. Paul in 1943 made similar conclusions about the relation of Rheumatic Fever to the presence of a streptococcus germ belonging to Group A. If the above statement is of tremendous significance in the field of bacteriology, more important and significant is the interrelation of the bacteria to the host.

It is in this particular field that Rutstien, in 1947, mentioned the importance of the human tissue reaction to the attack or entrance of infection by streptococcus germs. Today, the above concept of the local tissue reaction in response to the attack of the infection is so predominant that many articles in medical journals make a special remark under the subject and name of Mesenchymal Disease to express such reactions and bring us indirectly to the field of allergy reactions, expressed in terms of structural allergy from the moment that such reaction takes place right in the localized tissue. Prof. William Koch of Detroit first described this concept years ago.

Observations made in our daily contact with rheumatic patients reveals a frequent association of allergy manifestations of different types (sinusitis, vasomotor rhinitis, etc.) associated with increased eosinophil rate on the differential blood count. On occasions, a local nodose manifestation on the skin is also a “reactional allergy’s” answer to the infected attack. From the above clinical and bacteriological interpretations, the Rheumatic Disease has made a definite change of position—etiologically speaking—in the field of pathology, to such an extent, that a disease considered to be produced by infected germs alone, has become, today, a disease of allergy interrelations.”

Professor R. V. Christie, in an article of the British Medical Journal, summarizes his observations made in more than 269 cases of bacterial endocarditis, by stating that allergy reaction may take place anywhere in the body including the heart structure. Sensitization of the cardio-vascular system makes the heart the “shock organ” and forms the basis from which cardiac or vascular disease may develop.

Cardiac allergy has not received the attention that it deserves in medical literature. The concept of cardiac allergy, cardiac reaction has found support by the repeated establishment of an infiltration of eosinophil leucocytes such as is found in diffuse interstitial eosinophilic myocarditis.

Allergy response in the coronary vessels is possible. Allergy reaction of peripheral vessels including arteries and veins may give rise to peri-arteritis nodose, thrombo angeitis, endo-arteritis obliterans, and phlebitis—all of them, give response to sensitization. In rheumatic carditis, the most important localization of the disease, the myocardial Aschoff body is the typical lesion.

Many investigators believe that Rheumatic Fever is a reaction from parental contact with the forming protein to which the tissue of the host has been previously sensitized. Along these lines, Dr. Cavelti of the Italian School has given an enlightening explanation on pathogenesis of Rheumatic Fever and carditis as follows: during or succeeding the streptococcus infection which precedes the rheumatic attack by about three weeks, an autogenous antigen is formed by a reaction, in which, a streptococcus substance or product is combined with components of the host tissue, perhaps connective tissue (Mesenchyme). This antigen incites the formation of specific antibodies, which can precipitate the rheumatic lesion by reacting ”in vivo” with the antigen situated in the tissue. Once the formation of antibodies has been incited: the streptococcus component is no longer necessary for the ensuing action of these antibodies of tissues.

Going back to the allergy factor in Rheumatic Disease, and making a brief summary of medical articles on the above subject, we find that as early as 1937, the Canadian School was one of the first to mention the interrelation between allergy and Rheumatic Disease. Dr. Arnott of London, Ontario, my distinguished professional friend, in his paper entitled ‘Rationales of a Fundamental Chemical Therapy’ mentioned a leading article published in the Journal of the Canadian Medical Association by Dr. H. B. Cushing of McGill University in Montreal. Dr. Cushing who spoke about Rheumatic Disease mentioned the fact that the widespread dispersion of the disease in the body tissues does not appear to be the result of one or two factors only, but also the result of favorable conditions for growth found occasionally in certain predisposed people. Here he was speaking of allergy.

Dr. Arnott mentioned also an article written by the Editor of the Journal of the Canadian Medical Association, April 1937, which said, “the majority of investigators seem to have fallen back to the theory of allergy.” The most plausible explanation, therefore, appears to be some form of allergy.

In Summary: Today, the majority of medical schools agree that the allergy condition is the one determining factor in the ultimate development of the heart lesions in Rheumatic Disease. More important is the fact that the right therapeutic measure will belong to a medication with power of the allergy factor which subject I will discuss extensively in the therapeutical section.

 

III. GROSS PATHOLOGY AND PHYSIOPATHOLOGY IN RHEUMATIC DISEASE

In our previous section we discussed the importance of allergy as a determining factor in the beginning of rheumatic disease and its ultimate destruction, the heart lesions.

Here in the gross pathology section, I will show you a sample of terrific destruction done by the rheumatic disease, when the process did not receive an early and appropriate treatment.

It is most unfortunate for the medical practitioner that a vast number of the rheumatic disease patients come to him in the ultimate stages, which have a high mortality rate. The day that the medical profession awakens to the fact that the correction of disease depends on an early diagnosis and an early understanding of the problems of allergy, many lives will he saved from the ultimate complications and crippling heart damage.

Rheumatic Disease is therefore, explained or determined by three fundamental factors:

1. a focal infection,
2. a biochemical disorder, and
3. an idiopathic allergy.

Let us examine the physio-pathological conditions of each determining factor:

As for the “focal infection” it is clearly understood, today, that the Group A. of Lancefield is the main etiological reason for Rheumatic Disease and on which pathology, the enzyme content of the capsule plays an important part in the effect made on the allergy determination. At this point, let us recall the statement of Professor Koch who said:

”The basis of allergy depends upon the ability of a fluorescent substance to absorb energy from exothermic chemical reaction going on in the medium (living cell) in which they absorbed. This absorbed energy increases the strain in the fluorescent substance, to a point, that the energy can no longer be retained and it has to be given off either as a radiation of resonated or of degraded value so the energy can be passed over to a suitable acceptor, a chemical system, into which the fluorescent substance is intimately absorbed, and which for greatest effectiveness possesses a range of energy absorption equivalent to the range of emission of the fluorescent substance. The energy so accepted, passes into the chemical reaction of the acceptor, forcing its function. Thus there is a, specificity of action, and only the functional unit of the cell that is able to accept the particular range of energy that a particular fluorescent substance can emit, is affected. When energy is thus transferred, the fluorescent substance is said to serve as a photochemic sensitizer, but specific range of emission and absorption is not always necessary for the acceptance.”

In our application of the phenomenon, the allergenic material (streptococcus capsule) is the sensitizer, and the particular cell structure that is forced to function determines the type of allergy and symptoms we observed (inflammatory joints).

There are certain facts observed clinically so often that they cannot be discounted. In a chronic Rheumatic Disease at the end of the recovery process, an acute inflammatory reaction takes place within and a focus of infection forms. For example, sinusitis or tonsillitis, or tooth abscess frequently appears. This focal infection developed along the path of the lymph drainage is credited with a casual relation to allergic activity or lesion.

The rule and progress of recovery is well known to us, who are engaged in the Oxidation Catalysts practice. The FIRST manifestation of disease (focal infection) to come is the LAST to disappear with recovery and the LAST to come (inflammatory arthritis) is the FIRST to go.

Now if we look again to our CHART 2 we see that there is another mechanism of allergy determination, in which no focal infection or germ is found. So I speak of biochemical disorders primarily, with secondary production of allergy manifestations. It seems to be that liver insufficiency occupies a preeminent position in these affairs, primarily in the physiological activity of the liver cell function, and secondary to the pathological changes operated on distal organs (nephritis and intestinal disorders).

The participation of liver activity and insufficiency in rheumatic disease has been so significant that it demanded the attention of a Mayo investigator, Dr. Kendall, and resulted in the production of a so-called “compound E” which was highly advertised a year ago in the correction of arthritis.

In Summary: the metabolic disturbance of the liver cell is a determining factor in the production of local biological changes in the liver oxidation, with ultimate production of allergy conditions.

Similarity of disturbances occurs in another important gland, the Pancreatic gland. Among diversified pathological processes of these glands, I will mention the “celiac disease” in which a metabolic disturbance is present with ultimate production of allergy manifestations in a form of distant bronchial manifestations (allergy bronchitis) and a local inflammatory reaction of the large joints (allergy rheumatism).

Finally, we recognize the endocrine disorders (thyroid or estrogenic) as factors in the production of allergy manifestations associated with Rheumatic Disease. These can be classed with the clinical manifestations of menopausical arthritis and migraine headaches as well as urticarian reactions, associated more or less with rheumatic disease.

In Closing: these brief physio-pathological descriptions, let us think about the Rheumatic Disease produced by an “idiopathic allergy” without focal infection or biochemical disorders described years ago by two of Mayo’s investigators, Drs. Phillip Hench and Edward Rosenberg in a 1943 publication of the Collected Papers of Mayo Clinic and Mayo Foundation.

They describe a type of rheumatic condition characterized by an acute arthritis with pain, swelling, redness of one or more joints, which attacks suddenly develops rapidly, lasts only a few hours or a few days, then disappears completely but recurs at irregular intervals.

In 1935, two other independent investigators described a type of Rheumatic Disease closely related to Rosenberg’s Palindromic Rheumatism. This type, an allergy manifestation, was called the “SOLIS COHEN Angio-neural Arthrosis” in which the chief symptomatic elements were pain, swelling, discoloration and fever, which emphasized the frequent occurrence of hives, dermographism and other evidences of vasomotor manifestations. In 1939, still another investigator, Dr. Kahimeter, described the so-called allergy type of arthritis with 54 clinical observations.

 

IV. CLINICAL SYMPTOMS IN RHEUMATIC DISEASE

Our Clinical Observations can be described in three separate groups:

1. Atypical Forms
2. Acute Forms
3. Chronic Forms

When recording clinical observations, it is necessary to avoid the repetition of clinical manifestations well described in all medical textbooks. For the busy practitioner, it is more important to know the symptoms and manifestations more frequently seen in daily practice.

1. Frequently the “Atypical forms” of Rheumatic Disease which occupy a prominent place in the daily practice are misrepresented to such an extent that, for years, these patients or doctors arc not awake to the facts of their importance. Minimal distresses (neuritis, torticollis, foot aches, bursitis, spinal distress) are not recognized as important and yet, they are the first warnings in the ultimate progress to a heart involvement.

In our estimation, the “minimal complaints” in Rheumatic Disease are early expressions of an “allergy disease” and have been present always in every one of our clinical histories.

The majority of longstanding cases of Rheumatic Disease (chronic stage) refer to us a history of neuritis, bursitis, sacroiliac pains (lumbago) or foot complaints frequently called “foot arch complaints.” In other cases there are histories of tonsillitis attacks (strep throat) followed by chills and fever or acute exanthemas of the scarlet-fever type (strep).

Atypical Forms of Rheumatic Disease:

Among the atypical forms, there are two frequent and important developments, which on many occasions do the general practitioners misrepresent, and which are listed as the convulsive or epileptic type of rheumatic disease described years ago by an English physician, Dr. Sydenham.

Chorea is a typical convulsive form of the Rheumatic Disease, with a peculiar frequency among children. During the convulsive stage the patient loses consciousness for minutes or hours and is pale with muscular contractions over different parts of the body. The spells are repeated sometimes close together. In the majority of patients, they are overlooked.

Therapeutical measures are limited to symptomatical treatments with barbiturates, bromides and sedatives.

Chorea of Sydenham is an early manifestation of Rheumatic Disease with convulsive form and should be kept in mind by the general practitioner, particularly when the above manifestations occur in small children who complain with joints or muscular pains. It is in this stage where depressive medications by barbiturates not only delay the opportunity of making correct diagnosis but also underestimate the depressive action over the cardio-vascular system, which is always affected by the hemolytic strep.

If the above therapeutical action is mistaken the problem becomes more alarming and important when these patients reach the hands of the neurosurgeon.

Many convulsive stages of chorea are mistaken due to a brain injury or pathology vastly different from the Rheumatic Disease. These patients are classified as ones with brain tumor, blood clots or sclerotic meningitis before they wake up to the facts.

A surgical intervention is frequently ordered and on some occasions electric-shock treatments. In both cases, the surgical operation and the electrical shock treatments are only dangerous measures without any beneficial results in the convulsive stage of the disease.

Observation —1:

An eight-year-old girl has a history of convulsions, fever, leucocytosis, articular pains, heart murmur and recurrence of tonsillitis attacks.

A diagnosis of ”Rheumatic Chorea” was established and two cc. of the Oxidation Catalyst was given intramuscularly. During the months to follow, the child experienced typical reactions with recurrence of complaints. Consequently the family desired to consult a neurosurgeon of the locality who established a diagnosis of brain pathology.

A year later, our examination of this patient revealed a clear organic heart lesion (mitral stenosis)—a clear expression of overlooked rheumatic lesion.

Atypical Rheumatic Disease also made frequent manifestations of localized inflammatory process over the capsular joints (bursitis), with histories of local complaints (pain, swelling) frequently mistaken as a traumatic injury (sprain).

Here again, the regular practitioner misunderstands these Atypical Forms of Rheumatic Disease as well as the orthopedic surgeon. For the clinician, a great number of cases of bursitis are localized diseases not related to a rheumatic condition. A local treatment over the joint is established in the form of infrared lamp, diathermy, or manipulations, which are only therapeutical measures and give more temporary relief. In fact, bursitis usually recedes spontaneously and leaves an irreparable cardio-vascular lesion in a few weeks.

The bursitis as a pathological expression of rheumatic disease has been underestimated by the majority of practitioners, in whose estimation the local inflammatory reaction has no relation whatsoever with the infective mechanism of Hemolytic Strep.

As in Chorea disease, the surgeon frequently contacts Bursitis manifestations and a surgical operation more or less extending over the affected joint is performed with unnecessary mutilations.

Our Clinical files contain the typical case previously described.

Observation —2:

A forty-five year old female patient who had been afflicted for years with bilateral Bursitis of kneecaps had suffered pain and inflammation; to such an extent that ambulation was almost impossible. After years of unsuccessful medical treatments, she contacted an orthopedic surgeon who performed a bilateral resection of both kneecaps.

Following the operation, the patient still suffered with articular complaints, plus the limitations of activity as resulting from the surgical operation. The surgical resection of kneecaps as a treatment for kneecaps bursitis, appears to me as surgical intervention over the heart muscles to cure a coronary disease.

Again and again it is necessary to remind the specialized men that Rheumatic Disease is NOT a localized disease, which only the internist should treat.

Another frequent mistake among the Atypical Forms of Rheumatic Disease is the inflammatory process over the spinal column, which could be extended from the cervical region to the sacroiliac joints.

Over the cervical region, the patient feels a sensation of “cracking feeling” during the rotation of the head associated with stiffness of the muscular structure in the neck.

In the dorsal region, the inflammatory process in the inter-vertebral meniscus produces a distant pain manifestation over the abdominal organs, simulated on occasions by a gall-bladder attack or kidney complaint, which is quite frequently mistaken by the general practitioner.

These reflex manifestations are well understood, and were described years ago by Dr. Head under the name of “Head’s Metamerics Zones.” He described the particular relation of each vertebra to the nerve Plexus radiated through the inter-vertebral space.

When the localized inflammatory process affects the lumbar region a contractual process involves the lumbar muscles with pain and limitation of motion. The patient is forced to walk in a very peculiar position. This condition has been called “Lumbago.”

In general practice “lumbago” is frequently mistaken for kidney disease, and as rule, the inflammatory process spreads extensively to the sacroiliac joint on one side, with a displacement and compensatory position of the hip joints and temporary vertebral scoliosis. “Lumbago” patients suffer agony and a great deal of limitation in movements for days and weeks, with incapacity to work or even to attend personal care.

Another manifestation of “Atypical Rheumatism” is the “Neuritis” which is in the majority of cases secondary to a distant focal infection such as tooth abscess, sinusitis, etc. Among these particular forms of Rheumatic Diseases is found the sciatic neuritis, which is perhaps, the most painful and stubborn of the rheumatic group. It strikes suddenly, and usually involves one side. The pain is typically a burning sensation, which extends from the gluteal region, posterior, down to the thigh, and returns above the knee joint on the external side. In some instances it reaches as low as the foot, with partial inability of movements such as extension and flexing of the foot joint.

The severity of the attack keeps the patient in bed with a contractual position in the side affected. Clinically, it is an inflammatory process of the nerve in which the patient demands a quick action to obtain some relief from the misery and suffering.

Clinical manifestations of Rheumatic Disease such as have just been mentioned are numerous. In fact, your speaker was a patient years ago and he will never forget the limitations and complaints, which he had for several days.

There is no medication in the world with a quicker and more affective action in the treatment of Sciatic Neuritis than the injection of Glyoxylide. The relief follows in a few hours, and the rehabilitation to walk occurs in a few days. Attacks seldom recur after the Glyoxylide injection.

Also among the Atypical Forms of Neuritis are found the Brachial and Intercostal Neuritis with pains and limitations of movements.

2. Acute Forms of Rheumatic Disease:

Let us study the Acute Forms of Rheumatic Disease. If we look at Chart 3, we observe four (4) clinical types:

1b. —Strep Throat Infection

2b. —Scarlet Fever

3b. —Rheumatic-Carditis

4b. —Acute Inflammatory Poly-Arthritis

1b. In all the above clinical forms, the hemolytic Streptococcus is the responsible germ with independent entrance. The Strep throat infection is always acute at the onset with sore throat, redness, fever, chills, muscular pains, and increased leucocytes. Locally, the lymphatic structures of the cervical region are involved internally as well as externally. The attacks are sometimes mistaken for a “catarrh condition” and the tonsilar infection blamed for it with an urgent demand for extirpation (tonsillectomy).

Tonsillectomy in the above strep infection is a dangerous operation, particularly when performed in the acute stage of the disease. In the chronic stage, though, after the fever and inflammation subsides, the surgical operation should be avoided. A throat smear for culture should be obtained before any decision is reached.

Years ago, the bacteriological interpretation of positive culture of hemolytic Strep in the throat smear was not given the importance it deserved. The majority of the above patients carry on for months and years an infective process of tremendous virulence, which gradually involves the cardio-vascular system and distant joints. These patients experience a tired sensation, muscular pains in different locations as well as a mild hypochomic anemia and increased erythro-sedimentation.

2b. Scarlet Fever is an exanthema of the childhood age, acute at the onset, with severe throat complaints, high fever and lymphatic enlargement of the cervical glands. Despite the fact that the etiological factor in Scarlet Fever is accepted today to be a “virus infection,” the hemolytic Strep also plays an important role in the disease. Sequelae and complications frequently occur in the above disease in the form of bronchial pneumonia, kidney injury (nephritis) and heart lesion (valvular endocarditis).

3b. The Rheumatic Carditis is an Acute Form of Rheumatic Disease, associated with an inflammatory process over the cardio-vascular system. Acute on entrance, the onset of the symptoms are fever, tachycardia, dyspnea and heart insufficiency. It frequently occurs in patients between the ages of 30 and 50 years. The physical examination over the heart structure detects an organic heart murmur, irregular beats (extrasystoles) and typical E K G with increase of the P.R interval (partial block) and abnormalities in the complex Q-R-S and S-T waves. (See Figure 31)

As a rule, the Rheumatic Carditis has been classified in four different clinical stages or forms. According to Swift, they are frequently seen in the practice as:

a) High Toxicity Form

b) Recurrent Attacks

c) Chronic Stage With Activity

d) Chronic Stage Without Activity

The High Toxicity Form is always followed by a high mortality rate. The Recurrent Form is characterized by a period of activity and the rest of the clinical manifestations. The Chronic With Activity given as clinical symptoms of infected process lasts for months and years. Finally, the Chronic Inactivity is carried on by the patient for years without clinical manifestations with an organic heart lesion in the stage of fibrosis.

4b. A French physician, Dr. Boullaud, first described the Rheumatic-Poly-Arthritis or Classical Rheumatic Disease. The clinical picture is well known in general practice; the patient has an acute onset of manifestations, fever, pains and swelling over multiple joints. Over the heart the patient feels chest distress and pericardium friction. Skin manifestation adds in forms of subcutaneous nodules of white-gray color, hard to palpation.

These nodules are an expression of an organic effort to establish an immunity reaction, or a clear allergic manifestation to the infective organism.

Perhaps, the Rheumatic Poly-Arthritis is the most peculiar form of Rheumatic Disease with an acute stage in which the “blood picture” assumes a typical reaction. Frequently, there is an increase in the leucocytes between 15,000 to 20,000 as well over the erythro-sedimentation rate between 100 and 130 in the first hour (Wintergreen). The speed of the sedimentation rate gradually decreases during the recovery and convalescent period, and becomes of great value to the physician in the estimation of the prognosis. As a rule, a sedimentation rate above 20 mm. demands a prolonged rest in bed.

3. Chronic Forms of Rheumatic Disease:

Following the Atypical or Acute manifestations the Rheumatic Disease will become in the “chronic stage” under two forms: the Atrophic Rheumatoid Arthritis described years ago by Marie-Strumpell or the Hypertrophic Deformant.

Figure 82. Heart enlarged in all directions.

The Marie-Strumpell Disease has a peculiar localization over the spinal column segment with preference over the sacral region and with severe pains and ultimate ankylosis of the vertebral joints (spondilitis) as well as muscular atrophy of the hands and arms.

Some of these patients are also afflicted with involuntary control of movements similarly related to a Parkinson’s as well as mental distress. Liver cirrhosis has been described also in these patients. Brain damage and particular destruction or sclerosis of the involuntary muscular control of brain nucleus (nucleus pallidus) have been reported as pathological findings in these patients.

On the Hyperthropic Form the patients show a deformity in the joints of hands and feet with increased calcified deposits and ankylosis. They are the ultimate developments of Rheumatic Disease.

V. TREATMENT OF RHEUMATIC DISEASE

This section deals with important and extensive material, which will he made as brief as possible, particularly along the lines of orthodox treatments before the discoveries of antibiotics and endocrine substances.

Until recently, the treatment of Rheumatic Disease was only symptomatic with a group of medications well known to you (aspirin, phenacetin, pyramidon, sodium salycilate, sodium iodine, etc.) with inability to cure and to avoid the ultimate progress of disease, the cardiovascular damage.

Let us refresh our memories with an enlightening paragraph from an article found in the May 1950 Journal of Iowa’s Medical Society. It discusses the use of aspirin as follows:

“In many of the Rheumatic Diseases where there is no known cure, the important problem is to alleviate the symptoms and teach the patient to live with his disease. Pain must be controlled and sodium salyciate and ASPIRIN are the most economical and as effective as any of the more highly advertised drugs.

“The usual error is not giving a sufficient dosage for relief. Many patients can tolerate ASPIRIN in doses from 45 to 80 grains DAILY divided into morning, and evening doses and intermediate dose as necessary for relief.”

Do you believe that between the intermediary dose in the above therapy the physician’s services are needed any longer?

The cardio-vascular system certainly is not still standing after such a pounding.

Let us continue with the analysis. “At the onset it is advisable to use small doses of opiates to attain rest and COOPERATION of the patient.”

How much cooperation is to be expected from a patient who is asleep from the effects of opiates? Shall we hammer on his head?

If our previous dissertation (etiology and pathology sections) and clinical experiences all over the world show that rheumatic disease is an infective and Mesenchymal Disease with an early damage over the heart structure (myocardial damage) we should realize how dangerous is the indiscriminate use of ASPIRIN as a sure medication to obtain relief as it will end the patient’s life quicker than if lie did not use it.

The use of ASPIRIN in Rheumatic Disease as well as in any other disease should be avoided in the hands of any conscientious practitioner. Furthermore, commercialized advertisements through the radio should be prohibited from our daily programs, and should be branded as criminal and detrimental to the health of the people.

Among other measures, perhaps with a dangerous action similar to that of aspirin, are the gold salt preparations (Solganol B, Allocrysin, Sanocrysin, etc.). They are high in toxicity and detrimental to the reticulo-endothelial system on which the oxidation power is a main development during the entrance of the infective organism.

Frequently following the administration there appears kidney damage as well as severe dermatitis, a final expression of allergic intolerance.

The gold salts therapy in Rheumatic Disease should be a companion of the X-Ray therapy technique, which is another unfortunate therapeutic measure of the old orthodox system. The fibrosis and detrimental effect on the oxidation system is well known as is the secondary anemia following the applications of radiotherapy.

The discoveries of the Vitamin and the fact that the Rheumatic Disease might not be of microbial origin as many authorities held, but might be caused by some basic disturbance of the body’s chemistry, the use of Vitamins, on sight, became a promising medication without depressive effect on the patient’s system. Indirectly, all vitamin preparations contain, in the molecule structure, a carbon and oxygen arrangement with an internal catalyst action over the Mesenchymal structures.

Before the discovery of B12, the most extensive vitamin preparation in use for rheumatic disease was the Thiamin Chloride or Vitamin B1. From pharmacological activity, the Thiamin Chloride served as a group in enzyme systems.

In other words, it represented the prosthetic group of the coenzyme cocarboxylase. These enzymes catalyzed the decarboxylation of alfa-ket-acids, particularly pyruvic acid. If there is a deficiency of thiamin, there is also deficiency of the coenzyme cocarboxylase and of the enzyme carboxylase, with the associated high level of pyruvic acid and polyneuritis syndrome.

This explains the reason for relief of Atypical Rheumatic Disease (neuritis) from the thiamin treatment. However, the medication has only a limited therapeutical action, due to the fact of rapid elimination and repeated doses. Thiamin Chloride is practically ineffective in the correction of the allergy factor of the focal infection mechanism.

Two other interesting groups of vitamins with a field of applications in rheumatic disease are: the B12 and the Vitamin E (tocopherol). The Vitamin B12 has been used for relief of the toxic reactions (dermatitis) following the use of golden salts in rheumatic disease. Fibrostic symptoms are quite markedly alleviated in using B12 considerable improvement shows in the blood picture (rheumatoid anemia).

The vitamin E (alfa-tocopherol) is considered a respiratory enzyme but its most striking effects, in case of deficiency, are on the pituitary gland and reproduction in general muscular dystrophy and paralysis in rats, guinea pigs and rabbits and encephalomalacia in chicks.

Vitamin E has proved to be of practical use in the Chronic Rheumatic Disease (Marie-Strumpell Syndrome) associated with mental distress and muscular atrophy. Vitamin E can be used as a supportive medication for the cardio-vascular system (Rheumatic Carditis) with far superior results and with less toxic reaction than the digitalis preparations.

In Summary: Vitamins are exogenous catalysts and very effective. They are involved in all biologic oxidations ranging from bacteria to man.

The third period in the treatment of Rheumatic Disease became known with the discovery of the sulfonamide preparations. They are helpful only in eliminating aggravating infection. Among these preparations we shall recall the “azoic compounds” (Prontonsil and Neo-prontonsil).

Other derivatives are the sulfa-thiazol, sulfamerazine, and suhfadiazine.

In principle, the bacteriostatic effects of the above preparations have always been handicapped by their toxicity, as veil as the fact that they are highly depressive to the oxidation mechanism of the human body.

Among these depressive actions, the sulfa preparations seem to have a definite antagonistic effect over the reticuloendothelial system, as well as the hemopoietic system. Oftentimes, the administration on rheumatic disease patients is followed by the aggravation of the anemia leukopenia and agranulocytosis.

The fourth period in the treatment of Rheumatic Disease and sequelae came with the discovery of the antibiotics by Fleming, of which the penicillin drug is chief.

Here the field of therapeutical action is more acceptable when compared with the rest of the previous medications excepting the Vitamins.

Antibiotic preparations (penicillin) have been used successfully in the Acute State of Rheumatic Disease (septic endocarditis) and strep-throat infection. However, the medication is unable either to remove the infection completely or to prevent the recurrence of attacks.

Penicillin has been handicapped by both the depressive action on the cardio-vascular system and also by “the fast resistance” problem. On the other hand, the administration of this antibiotic is frequently followed by allergy manifestations of sensitive types, which have occurred more frequently since the production of the new preparation made with wax and peanut oil base.

A new antibiotic preparation, the aureomycin, does not seem to have quite the toxic effect, or to have the depressive effect on the cardio-vascular system or to show allergic manifestations in rheumatic patients. Symptoms of intolerance to the above drugs sometimes occur in forms of diarrhea and cystitis.

The fifth period in the history of the treatment of Rheumatic Disease began in 1929 when Dr. Phillip S. Hench, chief of the Mayo Clinic’s Department of Rheumatic Disease observed a curious problem connected with arthritic patients. He had noticed that when an arthritic woman became pregnant, the arthritis usually disappeared and be also observed that jaundice caused arthritis symptoms to fade away. The remissions were only temporary, however, for after the patient had given birth or had recovered from jaundice, the old swellings, stiffness and pain returned.

Dr. Hench believed that the anti-rheumatic factor was probably a substance which the body produced normally at all times, but that it poured into the blood-stream in greater quantities during jaundice and pregnancy. This suggested that the adrenal glands might be the source of this anti-rheumatic factor, because it was already known that, under other conditions of stress such as anesthesia, surgical operations and certain bacterial invasions, these glands rapidly increase their secretions.

If, indeed, it were true that jaundice and pregnancy stimulated the adrenal glands to secrete a hormone that neutralized rheumatism then the injection of the hormone on arthritic patients ought to have a similar effect.

Dr. Hench and Dr. Edward C. Kendall, chief of the Biochemical Laboratories of the Mayo Foundation for Medical Education and Research had often discussed the above hypothesis.

They had made an actual trial on a few rheumatoid volunteers with a cortical extract, but found that this mixed extract does not produce conclusive results.

Despite this set back, Dr. Kendall continued his efforts in order to obtain a more pure specific adrenal extract. So, in 1936, the father of the Cortisone isolated a series of crystalline hormonal substances from the adrenal cortex. It is a pure compound of established chemical structure and is now produced by a chemical synthesis. This product is commercialized under different names such as Percorten-Cortone-Cortison, etc., and which structural molecule complex is a linkage or carbon, oxygen and hydrogen atoms.

After a short period of clinical investigation Dr. Hench and his associate administered Cortisone to 13 arthritic patients (they used a daily injection of 100 mgm. for four days and then increased to 25 mgm. for 10 days).

In each instance improvement began within a few days, and continued as long as the full dose was given. A relapse followed as soon as the close was reduced or discontinued.

Thus the evidence was clear. There could be no doubt that Cortisone had the property of opposing rheumatism. This afforded an explanation for the curious ups and downs in the disease that Dr. Hench had observed; apparently the extra burdens imposed on the body by pregnancy and jaundice somehow increased the supply or utilization of cortisone.

To obtain a quantity of this compound the size of one small tablet, a half of a ton of adrenal glands from cattle was required. So, the only hope lay in the discovery of some means of producing these compounds by synthesis.

In January of 1944, Dr. Van de Kamp, senior chemist for the Merck Laboratory successfully isolated the synthesis of compound A, but its therapeutical action was of little value. A new compound was tried, the compound E, which was synthesized by Dr. Lervic Sarett almost simultaneously with the discovery by Professor Reichtein of Switzerland.

Lewin and Wassen, two Swedish investigators, observed the beneficial results of the combined injection of Dexycortone Acetate and ascorbic acid and recorded them in a paper published as early as 1949 (Lancet 2:993). In their opinion there is an inter-reaction of the two drugs, to such an extent that desoxycorticosterone must be available in muscles at the time of the wave of intravenous ascorbic acid occurs. In addition, as is well known, ascorbic acid is normally present in high concentration in the adrenal cortex and is rapidly depleted when this group of tissues is stimulated.

There is definitely some direct relationship, which exists between adrenocortical function and ascorbic acid metabolism.

It should be remembered also that ascorbic acid is an oxidation catalyst, and in the stage of low vitality due to any cause such as poor nutrition and advanced age, it is always associated with reduced Vitamin C production.

Therapy with Corticosterona does not always produce satisfactory results and on some occasions side effects, which are potentially disastrous, will take place if doses of the products are too high or too prolonged. The hormone has powerful action in causing retention of sodium and therefore an associated retention of water. Thus it may cause increased blood volume edema (peripheral, pulmonary or intra-cranial) elevation of blood pressure and enlargement of the heart shadow.

In patients with hypertension, a marked and possible more dangerous rise in blood pressure may follow the administration of cortisone.

Independent from the above side effects, the administration of adreno-cortical hormone in Rheumatic Disease is only a replacement or substitute therapy. Despite the well-advertised campaign of merits and miracles, results read by all of you in the Life Magazine months ago, questioned the mechanism of the production of the cortical hormone.

For the past few years and especially since the discovery of interrelated functions among the endocrine system, the close activity between the pituitary gland and the adrenal cortex has been known. The anterior lobe of the pituitary gland, smaller than the adrenal body, acts as a messenger to the adrenal cortex to such an extent that its function is considered to be the executive office that controls the internal secretions of many other glands including the thyroid, gonads, etc.

The pituitary stimulating action over the adrenal functions is known by the name of Adreno-Cortico-Tropic-Hormone A-C-T-H it is the A-C-T-H that commands the cortex to release cortisone. Therefore, instead of injecting cortisone, why not inject A-C-T-H?

A small quantity of a pituitary hormone might excite the adrenal gland to send out a large quantity of the cortisone hormone, and thus, the body would provide its own anti-rheumatic factor.

In February of 1949, Dr. Hench and his associates began to administer A-C-T-H in daily injections to arthritic patients at the Mayo Clinic. Within a few days, all symptoms of the disease began to diminish and this continued progressively as long as A-C-T-H was given in full dosage. The anti-rheumatic effects of A-C-T-H paralleled those of cortisone in practically every particular.

The production of A-C-T-H is more difficult and limited than the production of Cortisone and the synthesis of the pituitary gland has not been obtained up to the present time.

In Summary: the hormonal treatment in Rheumatic Disease marks, in the opinion of Mayo’s investigators, the opening of a new era in medicine. For us, Dr. Koch’s philosophy was opening this era twenty years ago.

Let us discuss the philosophical aspect of cortisone and A-C-T-H therapy compared with Dr. Koch’s research, which brought persecution in the past.

At the suggestion of Dr. John R. Mote, Medical Director of Armour Laboratory, a conference was called, bringing together those to whom he had given supplies of A-C-T-H, for the purpose of exchanging reports on the results of their use of the hormone. They met in Chicago for two days.

“Never have I attended such a conference,” reported one physician on his return home. “It was like a religious meeting, with men all over the house testifying to some seeming miracles. No medical gathering in history ever heard reports of so many DIFFERENT DISEASES YIELDING TO TREATMENT WITH A SINGLE DRUG. Acute asthma, pneumonia, chronic alcoholism, Rheumatic Fever, diseases described in the medical books as widely contrasting disorders each with its own pattern of symptoms, all had been mastered, at least during treatment by daily injections of A-C-T-H.”

Dr. J. S. Browne, Head of the Endocrine Research Laboratory at McGill University in Montreal, said, “the emotional impact of that Chicago Conference was terrific.” As disease after disease was reported, they sat enthralled, feeling that they were witnessing the beginning of a revolution, which, if revolution it was, was foreshadowed twenty years ago in Detroit by Dr. William Frederick Koch.

It was at Detroit not long ago (1946) that Dr. Koch and a half dozen courageous physicians began to tell the Food and Drug Administration of their now famous studies of the human body’s reaction to damage. When he spoke to them, of Oxidation Catalysis, cyclic-reactions and finally prolonged drug effect, his philosophy was branded as FRAUDULENT, DECEPTIVE and without therapeutical value. But today, members of the A.M.A., authorities in the field of endocrinology, are telling us of similar conclusions. Shall we call on the Food and Drug Administration and the Federal Trade Commission and tell them that these physicians are expressing a scientific opinion that is DECEPTIVE and FRAUDULENT? But there are more interesting features of the therapeutical background of cortisone and A-C-T-H.

Dr. Hans Selye, an authority on the adrenal glands, and Head of the Institute of Experimental Medicine and Surgery in the University of Montreal, described in 1949 the general adaptation syndrome of the human body to injury or disease. Under exposure to cold, fractures, infections, poison or other emotional trauma the human body responds in the same general ways, i.e. (1) the alarm reaction signaled by drastic physical changes, including extreme variations in blood pressure (2) the resistance stage in which these symptoms subside, but the body is extraordinarily sensitive to other forms of damage (3) the exhaustion stage when the body runs out of its capacity for defensive reactions and dies. Graphically speaking, in Dr. Brown’s estimation, the picture of disease with the basic reactions originally described by Dr. Selye can be represented by an iceberg of which seven-eighths is submerged in water.

This invisible area represents the body’s basic response to stress of all kinds and the upper part of the iceberg protruding above the water expresses the specialized responses of the body as manifestations of specific stresses. For example, the symptoms of Rheumatic Disease are the manifestations of the injury inflicted by the Hemolytic Strep Group A. of Lancefield; the symptoms of tuberculosis are the manifestations of the injury inflicted by the tubercle bacilli. But underlying them is the GENERAL RESPONSE of the body to damage of any kind, and it has just as great a significance as the special response to the infective organism. Without both the special and the general responses the disease does not exist. Generally speaking each disease is made up of this special pattern cropping out above the general response of the body.

Figure 33. Iceberg Theory of Disease is suggested by the early trials of cortisone and ACTH in several apparently unrelated infectious and degenerative disorders. Small amounts of the hormones have suppressed the symptoms of arthritis; larger amounts, the symptoms of asthma, pneumonia, and tuberculosis. This implies that the symptoms of disease are merely aspects of general response, or peaks on the iceberg of the body’s defense.

Figure 34. Arthritic ankles of two rats have been treated with desoxycorticosterone (top) and cortisone (bottom). The former has aggravated the disease; the latter has inhibited it. This response illustrates the delicate balance among the adrenal cortical hormones in the body.

The administration of Cortisone melts the iceberg so that the symptoms fall below the surface. But if you stop administering the hormones, the iceberg freezes again, and then, the arthritic stiffness and pain appear. In other words, the preparation does not retain prolonged drug effects due to its rapid elimination.

There is another interesting fact about the Cortisone therapy. From reading the leading articles concerning the developments and the isolation of the above hormones, Selye found that the cortex produces two hormones named the compound S and the desoxy-corticosterone, which when injected into experimental animals, aggravates the symptoms of disease.

However, when the cortisone is given to the same animal, the manifestations of disease gradually disappear.

In the estimation of the above investigator, the adrenal cortex hormone can both cause the disease and cure it, another statement that identified Dr. Koch ‘s philosophy issued 20 years ago.

In our interpretations, the reaction and aggravation of symptoms of disease following the administration of desoxycorticosterone has been erroneously misrepresented by the investigator. Instead of being interpreted as “producing disease hormone” it is just a local allergic manifestation of the hormone, which clinical manifestation will subside in the course of time.

Today, the chemistry engaged in the production of adrenal cortex hormones has been isolated into 27 different units, which perhaps, is just a matter of a tedious and too specialized technique. The so-called “steroids chemistries” are complicated matters beyond specialization, as well as new in the field of bacteriology, when they try to classify 33 different pneumococcus types and prepare specific serum for each one.

The type of the pneumococcus as well as the type of the steroid adrenal hormone is changeable in the internal chemical structure and molecular arrangements without significance to the existence of so many diversified products.

In closing the study of the pharmacological action of adrenal and pituitary hormones in the treatment of Rheumatic Disease, let us observe a frequent complication which occurs with the administration of A-C-T-H, that is, the development of hypertension and nephrosclerosis as a result of the administration of adreno-corticotropic extract of the pituitary gland, as you see in Figures 35 and 36. In general, the A-C-T-H therapy is used today not only in the treatment of Rheumatic Disease, but also in countless pathological conditions, particularly in Leukemia disease.

Figure 35. Enlarged kidney of a rat (top) is the result of the administration of adreno-corticotropic extracts of the pituitary. The resulting excess of adrenal cortical hormones caused the rat to develop hypertension and nephrosclerosis. A normal rat kidney is at the bottom.

The synthesis of A-C-T-H compounds is not available in our time, and the amount of pituitary extract required for ten treatments alone in one patient costs over $150.00. For this reason a substitute for the above therapy became known with the development of Pregnalone.

This material is a steroid hormone known also under the name of Natalone with similar action to the Progesterone.

 

Figure 36. Open skull of a young rat (top) is the result of the administration of desoxycorticosterone. The bones in the dome of the skull were pushed apart by the high blood pressure produced in the brain by the hormone. The closed skull bones of a normal rat are at bottom.

However, from the chemical structure, the Pregnalone or Natalone has a double bond in the 5-6 position and an 0-H (Hydroxyl) on carbon 3, instead of a Ketone radical typical of Progesterone.

In our practice we are making use of this compound particularly to combat fatigue and acute stress, frequently present in rheumatic patients. A dose of 50 mgm. given orally daily may be sufficient to maintain improvement.

No claim is made, however, that the above steroid compound is the long awaited cure for arthritic conditions. Clinical investigations have shown that it possesses definite advantages over other hormonal therapy in arthritic and related conditions, of which the following are of primary importance: (1) therapeutic efficacy, (2) absence of toxicity in a proper dose (3) some prolonged effects during the remission periods following discontinuance of therapy, (4) lack of influence on the carbohydrate metabolism, (5) does not intensify the diabetic stage, without necessity of increasing the insulin intake during administration (6) weight of patients and heart rates are unaffected, and (7) no changes in blood pressure occur, even in hypertensive patients.

In our clinic, the therapeutic dose is given orally at the rate of 300 mgm. per day, two tablets or 50 mgm. after each meal for 14 days. The following two weeks, one tablet after each meal (150 mgm.). The oral administration is also supplemented with one injection a week of 100 mgm. per cc. If no response is obtained within 30 days, the medication is discontinued.

Let us now study the final section in the treatment of Rheumatic disease. Your speaker refers to the Oxidation Catalyst drugs of Dr. William Koch of Detroit, Michigan in my estimation to be called the “Golden Fleece of Medical Research.”

To any observer, the steroid hormone therapy (Cortisone and A-C-T-H) remains far from having solved the complete recuperation of rheumatoid patients, and it is amazing that as far back as 1922 an Oxidation Catalyst drug was already being used successfully in the treatment of Rheumatic Disease.

Fundamentally, the pharmacological action of Koch’s carbon Oxidation Catalysts is not specifically for Rheumatic Disease its activity and curative results occupy a very prominent position in the minds of the general practitioner today.

The field of applications in Rheumatic Disease is broad, and very effective; however, the fundamental keystone of its therapeutical action is mainly the correction of the allergy mechanism always present in the Rheumatic Disease, as well as its unfailing power on the eradication of the focal infection where ever it is located.

Years ago, the interpretation of Rheumatic Disease and allergy interrelation was unknown and, perhaps, misrepresented. Unfortunately, similar errors have been occurring in other pathological conditions, particularly in cancer, with the loss of much time and many lives.

The slow advances, which have been made through the investigation in malignancy of the past fifty years, are now coming to fruition and are finding expression in chemical and allergy terms.

The carbon Catalyst has another superiority to the steroid medications. It is that the endocrine stimulant produces such an action that every patient’s gland is put back to work without depending on the administration of repeated hypodermic dosage. In other words, the rheumatic patient, under the Oxidation Catalyst drugs receives a stimulation in his own glands with definite increased level in the production of his own Cortisone and his own A-C-T-H.

Let’s study now the results of my experience and the percentages of recoveries made by the use of this drug on the different stages of Rheumatic Disease.

Glyoxylide is used in the majority of cases except that in the acute stages of infection (Strept throat) Benzoquinone is highly effective.

The prophylactic value of the Oxidation Catalyst drug in the field of Rheumatic Disease is of tremendous interest. A similar benefit is found in the prophylactic value in tuberculosis infection. This statement was made in our lecture at Detroit the past year.

An early clinical diagnosis of the Rheumatic Disease in the stage of primary lesion when the patient shows a clear symptomatology of allergy manifestations, makes correction easy if the administration of the aforementioned compounds is not delayed until the ultimate developments of extensive heart pathology have occurred.

When the true fact for the correction of the allergy mechanism becomes understood by the general practitioner, the group of miserable rheumatic diseased patients who save suffered so long that they must endure irreparable damage will be forever removed from our daily consultation and hospital work.

Prophylaxis means the application of the carbon compounds (Glyoxylide) in the beginning of the symptoms and at the proper time, particularly during the time that the patient’s resistance becomes lower due to exposure to a cold weakness, or nutritional deficiencies and the ‘natural immunity’ mechanism expressed in terms of oxidation mechanism, is in the breaking-down process. If patients are cared for properly at this time, the vast majority of heart ailments with increasing death rate in this country wilt be overcome early.

Let us turn our attention to the curative stage, which is the particular period when the patients come to us with clinical manifestations and complaints. They are divided into three groups:

Curative Stage:

a) Atypical Forms of Rheumatic Disease
b) Acute Forms
c) Chronic Forms

The use of Oxidation Catalysts in the treatment of Neuritis bursitis, Spinal arthritis, Lumbago, and Chorea (atypical forms) has been very satisfactory, with 75 to 80% of recoveries. The sciatic neuritis, particularly, responds very quickly. However, the recovery process in the months to follow is always in cycles, with periodical complaints until the complete elimination of the casual focal infection takes place. A very strict dietetic regulation with an especially low protein intake is recommended.

In Acute Forms such as Strep-throat infection, Rheumatic Carditis. Rheumatic Poly-Arthritis, etc., hospitalization of the patient is almost imperative. Hypodermoclysis should he used freely in the form of 5% saline 1000 cc. intravenously associated with the thiamin chloride. The administration of Glyoxylide is not followed by a quick release of complaints. As a rule, temperature, perspiration amid general complaints gradually subsides between the first and fifth days. The elimination of deformities is necessarily limited by the degree of permanent pathologic changes already existing.

A close observation of erythro-sedimentation test will be an important help in the prognosis of the patient. Our percentages of recoveries in the acute forms are between 60 to 75%. As a sedative for pain, we use (with good results) the Novaldine (Winthrop) grain 5 tablets on Hyocyamus 2x orally. When the clinical picture does not subside within five days after the first dose, a second dose of Oxidation Catalyst is repeated.

Special care should be given to tine heart condition: coramine, caffein-sodium-benzoate and, in cases with rate of pulse above 160, digifoline is advisable.

For the Chronic Forms, the treatment with the Oxidation Catalyst has given us some interesting facts. If you remember, the chronic forms of Rheumatic Disease (Hypertrophic or Atrophic type) is the ultimate stage of a systemic disease, with a severe injury in tine cardio-vascular system and particularly in the heart structure (septic endocarditis).

Before a patient of the chronic forms is treated, a thorough clinical examination should he made amid should include the E. K. G. in order to establish and evaluate the reserve capacity of the heart. Here the myocardial damage plays an important part in the chances for recovery.

The Rheumatic Carditis, in terminal stage, is so predominant, that occasionally it overshadows the rheumatoid symptoms. Dyspnea, swelling of the lower extremities, auricular fibrillation or auriculo-ventricular blocks are frequent manifestations.

The administration of Oxidation Catalysts in this particular stage should be avoided. Patients, who despite our warning, insist upon being treated, develop in the months to follow (six or nine weeks) an embolism (thrombus) or acute left ventricular insufficiency. The right ventricular insufficiency is slower and is not associated with edema of any kind except a typical respiratory complication (pulmonary edema).

Patients, suffering from Rheumatic Carditis and in whom the myocardial damage is not extensive, but in who there is found valvular lesion (endocarditis), have shown improvement after the administration of Oxidation Catalysts. Some of the patients showed partial stroke paralysis from distant embolism, and even in this stage the improvement is remarkable.

Our percentage of recoveries in this group of Chronic Rheumatoid Disease is 15 to 20% in the sub-acute stage and are the top failures with the administration of Glyoxylide. On the second group without manifestations of active infection over the heart, the percentage of recovery is somewhat better, between 20 to 30%.

In Summary: the recovery percentage reaches a high pitch in the Prophylactic Stage as well as in the Atypical Forms, while the top-failures are in the ultimate Chronic Stage of heart damage (septic endocarditis).

Percentage of Recovery:

1—Prophylactic stage 80 to 90%

2—Atypical stage 75 to 80%

3—Acute forms 60 to 75%

4—Chronic forms 15 to 20%

In closing these lectures, and particularly this section on Rheumatic Disease treatment, our clinical experience in using the Koch Oxidation Catalysts for the past five years shows us that this drug possesses a definite advantage over the rest of the therapeutical measures including the late development, the steroid therapy with cortisone and A-C-P-H.

The advantages of the medication should be summarized as follows:

Koch’s Oxidation Catalysts Supremacy:

1. It is a non-toxic medication

2. A single dose as a rule

3. Prolonged effect

4. Minimal supporting booster medication

5. Correction of the allergy factor

6. Correction of the focal infection

7. Stimulation of the steroids activities

8. Free from side effects (High blood pressure, changes in carbohydrate metabolism)

9. Beneficial results over fibrosis and sclerotic tissues

10. Large percentage of recoveries

11. Incalculable value to the public

 

VI. SUMMARY AND CONCLUSIONS

1. The Rheumatic Disease is a pathological condition and its importance has been increasing alarmingly during the past years due to the heart complication always present from the first appearance of complaints.

2. Statistics show that with tine exceptions of cancer and tuberculosis, Rheumatic Disease occupied first place in the past year’s death rate in the U. S. and there are 600,000 new cases every year.

3. Etiologically speaking, the participation of the allergy factor occupies a prominent place in the development of the disease.

4. The focal infection occupies today a secondary place: as a causative agent the Hemolytic Streptococcus Type A of Lancefield is a number one bacteria.

5. Clinically, the manifestations of the disease, particularly the so-called “Atypical Forms,” are not fully interpretative by the general practitioner.

6. Among these Atypical Forms, the conclusive stage in children is frequently mistaken for brain pathology (Chorea of Sydenham).

7. Therapeutically speaking, the treatment of Rheumatic Disease has been a puzzle to the medical science and the majority of remedies have been only symptomatic.

8. Symptomatic medications such as Aspirin, Pyramidon, Phenacetin, etc. as well as gold preparations should be avoided in the treatment of Rheumatic Disease.

9. The new era in the therapeutical field has been highly advertised recently with the appearance of the hormonal compound (Steroids) of Mayo’s investigators.

Addendum: 'Dr. Baldor and His Hospital', a letter from Ms. R. K. Haley

By R. K. Haley

In November 1939, my father died at Cornell Medical Center (Memorial Hospital, New York City) of leukemia. At this time, Dr. Dusty Rhodes said, “There is no cure for leukemia.”

In 1941, a friend’s father, Mr. Smith, developed leukemia. I wrote Dr. Rhodes and asked if there were any recent developments. He answered, “No”. But my friend had heard of a doctor who apparently was treating leukemia successfully. I advised her against taking her Dad to a “Quack” and throwing her money away. But she drove him to Tampa, Florida, when he was too weak to walk, and stayed with him daily at the small hospital operated by the doctor, for two weeks. They returned and the 71-year-old man begins to gain strength and finally recovered, apparently, as three years later a blood test showed no leukemia. So the local doctor said it must have been a “Misdiagnosis”. He died of a heart attack about seven years later while he was on a deer hunt.

After Mr. Smith’s apparent cure, I felt compelled to look into the treatment given by this doctor. I went to meet the doctor and saw his hospital, which was small (only 17 rooms) and spotless. A drinking fountain of spring water was in the hail, and it was a busy, well-run establishment. I had a hard time convincing the doctor that I was purely a humanitarian and a harder time getting his ear, as the waiting room was always full. But I listened and watched. He treated all illnesses, but was well known for his success in cancer treatment.

Shortly thereafter, a child of a friend, who was very poor, was diagnosed as having leukemia. I paid all expenses to send the child for two week’s treatment. The child returned and recovered and resumed a normal life. The child was put on a limited diet. Last heard of, fifteen years after treatment, he was fine and normal. Then, an older person developed leukemia-and he was arrested or cured, but he had to live on a rigid diet. He also fared well. Then there were those who went and did not stay on a diet, and later died.

Finally, I became ill with multiple complications: sinus, bronchiectasis, kidney complications, colitis for more than nine years, and a severe rash. I went to this hospital and was put to bed and the doctor said he would first purge me and would see me in a few days. I was given prune and apple juice and non-acid liquids for three days-no solids. The fourth morning, I had cream of wheat. Honey daily-only whole wheat or rye bread-and finally, some salad, etc. All vegetable and foods used were not chemically sprayed. Many items grown with manure rather than fertilizer. I received two or three high enemas. This was in 1945.

The third morning he came and said that as all poisons and chemicals were out of my system, I was ready for a thorough examination and he started my blood tests. They gave me X-rays, barium for colitis, watched progress, blood counts, etc.- normal procedures by well-trained nurses.

The fourth day I was given my first Glyoxylide treatment (Dr.Koch’s) then I was given Staphage Lysate by inhalation treatment and had a violent reaction about 4 or 5 hours later. Chills, fever, coughing fit, diarrhea, and pains in my right hand. The nurses piled me with blankets and I went to sleep and slept several hours. Then I awoke. I felt better than I had in years.

The next day, the doctor gave me another SPL treatment, and every other day for 14 days, the SPL was administered. I never had another reaction to the SPL. When I left the hospital, less than three weeks after entering, I was without sinusitis or even bronchitis (much less bronchiectasis) and was on the road upward. This was the first time in eight or ten winters that I was not subject to periodic trips and several days visits to the hospital for injections of various so-called “wonder drugs”. The reason I had finally decided to go to this hospital was because a team of medical men wished to operate and scrape my bronchial sacs, but they admitted this would not cure the cause of my trouble.

I was sent home from my wonderful doctor’s hospital with a very rigid diet: no whiskey in any form, no tobacco, coffee, meat, fried foods, white bread (except water ground meal) but no refined flours, no white sugar, etc., etc. I adhered rigidly to the diet and he gave me Dr. Koch’s cookbook, and in six months I was a new woman. Then he said that I should eat only, in place of meat, fowl, for another six months, which I did, and at the end of the year, I was allowed to resume a normal diet with discretion. I have since always maintained this diet within reason.

During the three weeks I was in the hospital, after I felt well enough, I began to talk to the patients and found that the doctor was held in such high esteem by many that they nearly thought of him as a God. I spoke to several terminal cancer patients who had been given up, whom he had treated. Some (a few) he actually cured completely and others he arrested. Almost all had the pains relieved and many had resumed a normal life—excellent results also with arthritis.

Later, I wrote the doctor and asked his cooperation in surveying each patient who had gone to him for treatment. He cooperated, because he knew by then (I’d known him three years or more) that I was sincere in my intentions and had paid to have several patients treated. He had patients who apparently were “cured” of leukemia or other incurable diseases like cancer, and today, are still living.

About this time, the doctor’s work came to the attention of the AMA. A lawsuit was instigated by a poor man with a terminal cancer, who had already had a portion of his jaw removed before going to my doctor. He continued to drink whiskey and the cancer continued to grow and he sued my doctor. The case was a big one and there was much publicity over it. His hospital was taken away and the doctor was discredited as a “quack”. He lost his license and everything he had and was forced to sell his hospital in order to pay damages. He left town, but not before I found that the poor man who sued him had been financed by total strangers, who brought in lawyers from New York, Chicago, etc., etc. so the AMA apparently accomplished their objectives through this patient.

Defeated, my doctor went to Cuba. This was long before Castro was on the scene. There he built up a practice. Once I was again taken with a bad attack and flew there and he again corrected my conditions.

I am told that after Castro took over, my doctor was forced to leave Cuba and tried to get work in the United States, but at every point he was defeated by the AMA. He eventually ended up living permanently in the Canary Islands.

Colleague Publications